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GENE：FGB

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FGB
FullNmae fibrinogen beta chain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3662
EnsembleID ENSG00000171564
Uniprot P02675

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FGB apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FGB apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FGB GO:0002250,GO:0005102,GO:0005198,GO:0005201,GO:0005201,GO:0005515,GO:0005576,GO:0005576,GO:0005577,GO:0005615,GO:0005615,GO:0005615,GO:0005783,GO:0005886,GO:0005938,GO:0007160,GO:0007160,GO:0009897,GO:0009986,GO:0031091,GO:0031093,GO:0031639,GO:0034116,GO:0042730,GO:0043152,GO:0044320,GO:0045087,GO:0045202,GO:0045907,GO:0045921,GO:0050714,GO:0050839,GO:0051087,GO:0051258,GO:0051592,GO:0062023,GO:0062023,GO:0065003,GO:0070062,GO:0070374,GO:0070527,GO:0070527,GO:0071347,GO:0072378,GO:0072378,GO:0072562,GO:0090277,GO:1900026,GO:1902042,GO:1903561,GO:2000352

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FGB hsa:2244 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
FGB hsa:2244 path:hsa04611 Platelet activation - Homo sapiens (human)
FGB hsa:2244 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
FGB hsa:2244 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PITX3 FGB 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CEBPA FGB 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXM1 FGB 15737987 trascriptional regulation,stimulation inferred by curator TFlink
AR FGB N/A trascriptional regulation,stimulation inferred by curator TFlink
PPARA FGB N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002E92A8 FGB 20570858 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000076995 FGB 20570858 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000272A3D FGB 20570858 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS0000081E1F FGB 20570858 rna interference,inhibition experimental interaction detection,miRNA interference luciferase reporter assay miRSponge
URS0000081E1F FGB 20570858 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,miRNA interference luciferase reporter assay TarBase
URS0000272A3D FGB 20570858 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00002E92A8 FGB 20570858 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000076995 FGB 20570858 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000042935A FGB 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 FGB 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 FGB 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE FGB 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002D349B FGB 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FGB FGA 25361965 interaction type N/A PTMCode2
FGA FGB 25361965 interaction type N/A PTMCode2
FGB F2 25361965 interaction type N/A PTMCode2
F2 FGB 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GPKOW FGB 25348397 N/A physical interaction ComPPI
AIMP2 FGB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAK2 FGB 25348397 N/A physical interaction ComPPI
OXSR1 FGB 25348397 N/A physical interaction ComPPI
CDKN1A FGB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TK1 FGB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GCA FGB 25348397 N/A physical interaction ComPPI
LSM1 FGB 25348397 N/A physical interaction ComPPI
RING1 FGB 25348397 N/A physical interaction ComPPI
H2BC4 FGB 25348397 N/A physical interaction ComPPI
SMN1 FGB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
KHDRBS2 FGB 25348397 N/A physical interaction ComPPI
GRB7 FGB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAK1 FGB 25348397 N/A physical interaction ComPPI
PTPN11 FGB 25348397 N/A physical interaction ComPPI
CPNE1 FGB 25348397 N/A physical interaction ComPPI
RHOA FGB 25348397 N/A physical interaction ComPPI
ARHGAP1 FGB 25348397 N/A physical interaction ComPPI
GNAQ FGB 25348397 N/A physical interaction ComPPI
PIK3R3 FGB 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
USO1 FGB 25348397 N/A physical interaction ComPPI
SERPINA5 FGB 14525934 25348397 27898060 8148485 8384496 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
DUSP3 FGB 25348397 N/A physical interaction ComPPI
PIR FGB 25348397 N/A physical interaction ComPPI
TLN1 FGB 25348397 N/A physical interaction ComPPI
SNX6 FGB 25348397 N/A physical interaction ComPPI
CALR FGB 14525934 25348397 27898060 7592883 N/A biophysical,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
FEN1 FGB 25348397 N/A physical interaction ComPPI
MAP2K1 FGB 25348397 N/A physical interaction ComPPI
HDLBP FGB 25348397 N/A physical interaction ComPPI
MAPK6 FGB 25348397 N/A physical interaction ComPPI
SPR FGB 25348397 N/A physical interaction ComPPI
PAPOLA FGB 25348397 N/A physical interaction ComPPI
SF3A1 FGB 25348397 N/A physical interaction ComPPI
TCEA1 FGB 25348397 N/A physical interaction ComPPI
GTF2F1 FGB 25348397 N/A physical interaction ComPPI
PRKCI FGB 25348397 N/A physical interaction ComPPI
VRK1 FGB 25348397 N/A physical interaction ComPPI
NARS1 FGB 25348397 N/A physical interaction ComPPI
FBLN1 FGB 14525934 25348397 27898060 7642629 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
PYGB FGB 25348397 N/A physical interaction ComPPI
FGB NID1 14525934 1680863 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FGB FGA 12356313 14525934 14992584 18294856 21475196 24234451 25348397 physical association experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,in vitro,atomic force microscopy ComPPI,HPRD,IntAct
FGB FGG 12356313 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FGB LPA 10980194 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
FGB ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FGB FN1 25348397 N/A physical interaction ComPPI
FGB CSNK2B 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FGB ASB6 25348397 N/A physical interaction ComPPI
FGB ASB7 25348397 N/A physical interaction ComPPI
FGB ASCC1 25348397 N/A physical interaction ComPPI
FGB TMEM237 25348397 N/A physical interaction ComPPI
FGB ALDH2 25348397 N/A physical interaction ComPPI
FGB H2BC11 25348397 N/A physical interaction ComPPI
FGB SBDS 25348397 N/A physical interaction ComPPI
FGB SNX27 25348397 N/A physical interaction ComPPI
FGB ADK 25348397 N/A physical interaction ComPPI
FGB NAA15 25348397 N/A physical interaction ComPPI
FGB NME2 25348397 N/A physical interaction ComPPI
FGB POU2F1 25348397 N/A physical interaction ComPPI
FGB SLK 25348397 N/A physical interaction ComPPI
FGB EIF2A 25348397 N/A physical interaction ComPPI
FGB BLVRB 25348397 N/A physical interaction ComPPI
FGB CTNNBL1 25348397 N/A physical interaction ComPPI
FGB TBC1D24 25348397 N/A physical interaction ComPPI
FGB SNX3 25348397 N/A physical interaction ComPPI
FGB ATG3 25348397 N/A physical interaction ComPPI
FGB CCNYL1 25348397 N/A physical interaction ComPPI
FGB PMVK 25348397 N/A physical interaction ComPPI
FGB MCTS1 25348397 N/A physical interaction ComPPI
FGB PUS7 25348397 N/A physical interaction ComPPI
FGB ARMT1 25348397 N/A physical interaction ComPPI
FGB ITPA 25348397 N/A physical interaction ComPPI
FGB LZIC 25348397 N/A physical interaction ComPPI
FGB ADSL 25348397 N/A physical interaction ComPPI
FGB DENR 25348397 N/A physical interaction ComPPI
FGB HMGCS1 25348397 N/A physical interaction ComPPI
FGB KIF2A 25348397 N/A physical interaction ComPPI
FGB ETF1 25348397 N/A physical interaction ComPPI
FGB UBE2T 25348397 N/A physical interaction ComPPI
FGB LETM1 25348397 N/A physical interaction ComPPI
FGB PYM1 25348397 N/A physical interaction ComPPI
FGB PSME2 25348397 N/A physical interaction ComPPI
FGB CTH 25348397 N/A physical interaction ComPPI
FGB OTUB1 25348397 N/A physical interaction ComPPI
FGB FTO 25348397 N/A physical interaction ComPPI
FGB HDGFL2 25348397 N/A physical interaction ComPPI
FGB PNPO 25348397 N/A physical interaction ComPPI
FGB VPS26A 25348397 N/A physical interaction ComPPI
FGB NAA50 25348397 N/A physical interaction ComPPI
FGB RBM12 25348397 N/A physical interaction ComPPI
FGB EIF3J 25348397 N/A physical interaction ComPPI
FGB RPRD1A 25348397 N/A physical interaction ComPPI
FGB PAPSS1 25348397 N/A physical interaction ComPPI
FGB UBA1 25348397 N/A physical interaction ComPPI
FGB RPRD1B 25348397 N/A physical interaction ComPPI
FGB FARSB 25348397 N/A physical interaction ComPPI
FGB DDAH1 25348397 N/A physical interaction ComPPI
FGB PBK 25348397 N/A physical interaction ComPPI
FGB CAB39 25348397 N/A physical interaction ComPPI
FGB TES 25348397 N/A physical interaction ComPPI
FGB DIS3 25348397 N/A physical interaction ComPPI
FGB SCRN1 25348397 N/A physical interaction ComPPI
FGB SYAP1 25348397 N/A physical interaction ComPPI
FGB GLS 25348397 N/A physical interaction ComPPI
FGB GNL1 25348397 N/A physical interaction ComPPI
FGB KLK6 12878203 24234451 25348397 protein cleavage protease assay ComPPI,IntAct
DDX19B FGB 25348397 N/A physical interaction ComPPI
MIS12 FGB 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
PPID FGB 25348397 N/A physical interaction ComPPI
EEF1A2 FGB 25348397 N/A physical interaction ComPPI
UBLCP1 FGB 25348397 N/A physical interaction ComPPI
KIAA1143 FGB 25348397 N/A physical interaction ComPPI
RSL1D1 FGB 24234451 30021884 physical association cross-linking study IntAct
FGB ITGB1 15031111 27898060 N/A N/A OmniPath
FGB ITGB2 16601240 27898060 N/A N/A OmniPath
FGB ITGAM 16601240 27898060 N/A N/A OmniPath
FGB ITGA2B 2018974 27898060 N/A N/A OmniPath
FGB ITGA5 15031111 27898060 N/A N/A OmniPath
FGB ITGAV 15031111 27898060 N/A N/A OmniPath

Visualization










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