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GENE：FGFR3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FGFR3
FullNmae fibroblast growth factor receptor 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3690
EnsembleID ENSG00000068078
Uniprot P22607

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FGFR3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FGFR3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FGFR3 GO:0000165,GO:0001501,GO:0001958,GO:0002062,GO:0003416,GO:0004713,GO:0005007,GO:0005007,GO:0005515,GO:0005524,GO:0005576,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0005925,GO:0007169,GO:0007267,GO:0007275,GO:0008284,GO:0008284,GO:0008543,GO:0008543,GO:0009986,GO:0010518,GO:0017134,GO:0017134,GO:0018108,GO:0030133,GO:0030282,GO:0033674,GO:0035988,GO:0042531,GO:0042802,GO:0043235,GO:0043410,GO:0043410,GO:0043552,GO:0043552,GO:0046777,GO:0048640,GO:0060349,GO:0060349,GO:0070374,GO:0070977,GO:1902178

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FGFR3 hsa:2261 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa04144 Endocytosis - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa05219 Bladder cancer - Homo sapiens (human)
FGFR3 hsa:2261 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FGFR3 FRS2 12767520 17496910 17673906 26192618 interaction type N/A ACSN
FGF9 FGFR3 10574949 23331499 8576175 8663044 stimulation N/A SignaLink
FGFR3 Q7SX76 20802085 N/A N/A SignaFish
KDRL FGFR3 20802085 N/A N/A SignaFish
FGFR3 Q5K373 20802085 N/A N/A SignaFish

Source Target Pmid Interactiontype Methods Database
GRB2 FGFR3 20005715 interaction type N/A PSP
SH2B1 FGFR3 11827956 18988627 20005715 interaction type N/A PSP,SignaLink
GRB2 FGFR3 20005715 21071413 9045692 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 FGFR3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FGFR3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA FGFR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FGFR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FGFR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FGFR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FGFR3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SHOX FGFR3 21273290 trascriptional regulation,stimulation inferred by curator TFlink
SP1 FGFR3 22334592 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 FGFR3 22334592 trascriptional regulation,stimulation inferred by curator TFlink
SP3 FGFR3 22334592 trascriptional regulation,stimulation inferred by curator TFlink
SP4 FGFR3 22334592 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 FGFR3 16410555 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A FGFR3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001A405B FGFR3 19396866 19843843 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000157026 FGFR3 19843843 21383697 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001A405B FGFR3 19396866 19843843 23778488 23778527 25416803 26604796 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000157026 FGFR3 19843843 21383697 24456664 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000003ABC4 FGFR3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000000C73C FGFR3 23174883 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000048BA36 FGFR3 23174883 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000076B539 FGFR3 23313552 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FGFR3 FGFR3 22135298 phosphorylation N/A PhosphoSite
FGFR3 CTNNB1 22135298 phosphorylation N/A PhosphoSite
FGFR3 RPS6KA3 22135298 phosphorylation N/A PhosphoSite
FGFR3 PTEN 22135298 phosphorylation N/A PhosphoSite
FGFR3 STAT1 22135298 phosphorylation N/A PhosphoSite
FGFR3 FGF2 25361965 interaction type N/A PTMCode2
FGF2 FGFR3 25361965 interaction type N/A PTMCode2
FGFR3 STAT3 25361965 interaction type N/A PTMCode2
STAT3 FGFR3 25361965 interaction type N/A PTMCode2
FGFR3 GRB2 25361965 interaction type N/A PTMCode2
GRB2 FGFR3 25361965 interaction type N/A PTMCode2
FGFR3 FGF9 25361965 interaction type N/A PTMCode2
FGF9 FGFR3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GPSM3 FGFR3 14525934 14667819 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
HBZ FGFR3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
SOCS3 FGFR3 25348397 N/A physical interaction ComPPI
HSPA8 FGFR3 25348397 N/A physical interaction ComPPI
ARRDC3 FGFR3 25348397 N/A physical interaction ComPPI
STAT1 FGFR3 10918587 11294897 11839738 12637327 12817007 14525934 15322115 25348397 7543024 7657660 7690989 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SLC25A6 FGFR3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HSP90AB1 FGFR3 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
PTK2B FGFR3 14525934 15105428 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SOCS1 FGFR3 25348397 N/A physical interaction ComPPI
FGF3 FGFR3 14525934 25348397 8663044 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRB2 FGFR3 14525934 25348397 9045692 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ATF3 FGFR3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR2 FGFR3 25348397 N/A phosphorylation reaction,physical interaction,protein kinase assay ComPPI
FGF5 FGFR3 14525934 25348397 8663044 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SDC2 FGFR3 25348397 N/A physical interaction ComPPI
HSP90AA1 FGFR3 25348397 N/A physical interaction ComPPI
NECTIN1 FGFR3 25348397 N/A physical interaction ComPPI
HSPA1A FGFR3 25348397 N/A physical interaction ComPPI
HSPA1B FGFR3 25348397 N/A physical interaction ComPPI
FGF9 FGFR3 10574949 14525934 25348397 8576175 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HNRNPL FGFR3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RPS6KA3 FGFR3 25348397 N/A physical interaction ComPPI
CCN2 FGFR3 23142580 24234451 25348397 N/A protein array ComPPI,IntAct
PKM FGFR3 25348397 N/A protein kinase assay ComPPI
CTSK FGFR3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 STAT3 10918587 11294897 11350938 11940572 12244095 12576423 12626508 14525934 14551213 24234451 25065853 25348397 8626374 association anti bait coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
FGFR3 RPL8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 CEP126 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FGFR3 EPHA4 14525934 16365308 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FGFR3 FGF2 10574949 14525934 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FGFR3 FGF6 14525934 25348397 8663044 N/A experimental interaction detection,in vitro ComPPI,HPRD
FGFR3 FGF7 14525934 25348397 8663044 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FGFR3 FGF4 14525934 25348397 8663044 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FGFR3 FGF17 10751172 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FGFR3 FGF18 25348397 N/A in vitro ComPPI
FGFR3 FGF23 12032146 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
FGFR3 KRT8 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 GTF3C1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 RADIL 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
FGFR3 CCDC17 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FGFR3 ARAP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 POLA2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 GUSBP1 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FGFR3 NDUFS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 SMG7 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FGFR3 RNF130 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 BORA 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FGFR3 CHGB 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FGFR3 FGF1 10574949 14525934 14732692 24234451 25348397 N/A coimmunoprecipitation,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
FGFR3 FGF8 10574949 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo,surface plasmon resonance array ComPPI,HPRD
FGFR3 SH2B1 11827956 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
FGFR3 C6ORF47 14525934 14667819 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
FGFR3 HSPG2 24234451 24509440 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
FGFR3 HSP90AA2P 25348397 N/A physical interaction ComPPI
FGFR3 CDC37 24234451 25036637 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
FGFR3 HSPA4 25348397 N/A physical interaction ComPPI
FGFR3 SNX11 25348397 N/A physical interaction ComPPI
FGFR3 TMEM231 25348397 N/A physical interaction ComPPI
FGFR3 ILKAP 25348397 N/A physical interaction ComPPI
FGFR3 SRPK2 25348397 N/A physical interaction ComPPI
FGFR3 TMEM30B 25348397 N/A physical interaction ComPPI
FGFR3 ANOS1 25348397 N/A physical interaction ComPPI
FGFR3 FGFR3 11294897 14525934 14732692 23972473 24120763 24234451 phosphorylation reaction experimental interaction detection,nuclear magnetic resonance,surface plasmon resonance,protein kinase assay HPRD,IntAct
FGFR3 PTEN 11948419 19345329 22891331 27898060 N/A N/A OmniPath
FGFR3 FOXO1 10358014 11311120 11410590 27898060 N/A N/A OmniPath
FGFR3 STAT1 10918587 10921891 11023524 11294897 11316742 11390994 11823427 11839738 12138178 12165521 12383199 12637327 12817007 14498832 14978237 15322115 15767445 16205632 17237409 17277783 17379600 17442890 19174562 19287004 20974954 21511030 21576370 22508938 23043228 23139419 24882218 25921060 27898060 7543024 7657660 7690989 8197134 stimulant N/A OmniPath
HSP90AA1 FGFR3 21487019 22939624 27898060 N/A N/A OmniPath
FGFR3 STAT3 10918587 11294897 11350938 11940572 12244095 12576423 12626508 14551213 16497976 17016520 17389395 19901323 27898060 8626374 stimulant N/A OmniPath
FGF2 FGFR3 10574949 15780951 22298955 27898060 8663044 9045692 stimulant N/A OmniPath
FGF9 FGFR3 10574949 27898060 8576175 8663044 stimulant N/A OmniPath
FGF1 FGFR3 10574949 14732692 22244757 22298955 27898060 8576175 9045692 stimulant N/A OmniPath
FGF16 FGFR3 16597617 27898060 stimulant N/A OmniPath
FGF19 FGFR3 16597617 27898060 stimulant N/A OmniPath

Visualization










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