GENE：FHIT
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | FHIT |
| FullNmae | fragile histidine triad diadenosine triphosphatase |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3701 |
| EnsembleID | ENSG00000189283 |
| Uniprot | P49789 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| FHIT | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| FHIT | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| FHIT | GO:0000166,GO:0001650,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005886,GO:0006163,GO:0006163,GO:0015964,GO:0015964,GO:0031625,GO:0031625,GO:0032435,GO:0032435,GO:0042802,GO:0043530,GO:0047352,GO:0047627,GO:0047710,GO:0047710,GO:0072332,GO:0072332 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| FHIT | hsa:2272 | path:hsa00230 | Purine metabolism - Homo sapiens (human) |
| FHIT | hsa:2272 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| FHIT | hsa:2272 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| FHIT | hsa:2272 | path:hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | FHIT | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | FHIT | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | FHIT | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| YBX1 | FHIT | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | FHIT | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| PRDM14 | FHIT | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | FHIT | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | FHIT | 15044096 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| BRCA2 | FHIT | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000008A99 | FHIT | 21711110 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000060B2B | FHIT | 21711110 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS00001597DC | FHIT | 21711110 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000001A7A | FHIT | 21711110 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000008A99 | FHIT | 21711110 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000060B2B | FHIT | 21711110 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00001597DC | FHIT | 21711110 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000001A7A | FHIT | 21711110 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRC | FHIT | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| UBE2I | FHIT | 11085938 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| FHIT | GSN | 12833632 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| FHIT | SRC | 14525934 15835917 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| FHIT | FDXR | 25348397 | N/A | in vitro | ComPPI |
| FHIT | HSPD1 | 14525934 19004824 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| FHIT | CTNNB1 | 18077326 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| FHIT | LEF1 | 18077326 24234451 25348397 | association,physical association | anti tag coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct |
| FHIT | TRIM23 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| FHIT | RAB40B | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| FHIT | MDM2 | 25348397 | N/A | physical interaction | ComPPI |
| FHIT | REL | 25348397 | N/A | physical interaction | ComPPI |
| FHIT | ARHGAP19 | 25348397 | N/A | physical interaction | ComPPI |
| FHIT | MTMR6 | 25348397 | N/A | physical interaction | ComPPI |
| FHIT | RABL2A | 25348397 | N/A | physical interaction | ComPPI |
| FHIT | DDIT4L | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
| FHIT | FHIT | 14525934 16189514 18077326 24234451 25416956 27107012 9261067 9576908 | physical association | pull down,x-ray crystallography,two hybrid array,two hybrid pooling approach,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid,two hybrid | HPRD,IntAct |
| SRC | FHIT | 15007172 15835917 19004824 27898060 | N/A | N/A | OmniPath |
| FHIT | CTNNB1 | 18077326 27898060 | inhibition | N/A | OmniPath |
| BMX | FHIT | 2507541 27898060 | N/A | N/A | OmniPath |