Gene Information gene info

GENE:FIS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FIS1
FullNmae fission, mitochondrial 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:21689
EnsembleID ENSG00000214253
Uniprot Q9Y3D6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FIS1 mpt 39735538 Mechanistically, ATP5J silencing reversed dynamin-related protein 1 (Drp1) and mitochondrial fission 1 protein (Fis1) upregulation in microglia post-OxyHb induction; reduced mitochondrial overdivision, excessive mitochondrial permeability transition pore opening, and reactive oxygen species production; restored normal mitochondrial ridge morphology; and partially restored mitochondrial respiratory electron transport chain activity. retulator signature
FIS1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FIS1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FIS1 GO:0000266,GO:0000266,GO:0000266,GO:0000422,GO:0000422,GO:0001836,GO:0005515,GO:0005739,GO:0005741,GO:0005741,GO:0005777,GO:0005777,GO:0005778,GO:0005778,GO:0005783,GO:0005829,GO:0006626,GO:0007204,GO:0008053,GO:0008289,GO:0010821,GO:0016020,GO:0016559,GO:0016559,GO:0016559,GO:0032471,GO:0032991,GO:0035584,GO:0042802,GO:0043280,GO:0043653,GO:0043653,GO:0043653,GO:0051561,GO:0060090,GO:0070584,GO:0090141,GO:0090314,GO:1903579,GO:2000192,GO:2001244

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FIS1 hsa:51024 path:hsa04137 Mitophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 FIS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FIS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FIS1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FIS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00005651EE FIS1 22510686 rna interference,inhibition experimental interaction detection,chromatin immunoprecipitation assay,quantitative reverse transcription pcr miRSponge
URS00005651EE FIS1 22510686 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,chromatin immunoprecipitation assay,quantitative reverse transcription pcr TarBase
URS000017EA6A FIS1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
FIS1 DNM2 25361965 interaction type N/A PTMCode2
DNM2 FIS1 25361965 interaction type N/A PTMCode2
FIS1 DNM1 25361965 interaction type N/A PTMCode2
DNM1 FIS1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NOS3 FIS1 21163940 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ATP5F1B FIS1 24176932 24234451 25348397 27898060 colocalization fluorescence microscopy ComPPI,IntAct,OmniPath
KASH5 FIS1 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
JAGN1 FIS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 DNM1L 12861026 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
FIS1 MARCHF5 14525934 16874301 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
FIS1 UBC 16874301 24234451 25348397 physical association anti tag coimmunoprecipitation,in vivo ComPPI,IntAct
FIS1 UBA52 25348397 N/A in vivo ComPPI
FIS1 PEX11G 25348397 N/A physical interaction ComPPI
FIS1 PEX11A 25348397 N/A physical interaction ComPPI
FIS1 PEX11B 25348397 N/A physical interaction ComPPI
FIS1 GDAP1 25348397 N/A physical interaction ComPPI
FIS1 NOD2 21699783 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
FIS1 BCAP31 21183955 24234451 25348397 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,confocal microscopy ComPPI,IntAct
FIS1 CASP8 21183955 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FIS1 MIEF1 21701560 24234451 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
FIS1 TBC1D15 25348397 N/A physical interaction ComPPI
FIS1 A2M 25348397 N/A physical interaction ComPPI
FIS1 CDV3 25348397 N/A physical interaction ComPPI
FIS1 TOMM40 25348397 N/A physical interaction ComPPI
FIS1 HSD17B4 25348397 N/A physical interaction ComPPI
FIS1 VKORC1 25348397 N/A physical interaction ComPPI
FIS1 PEX5 25348397 N/A physical interaction ComPPI
FIS1 PRKN 25348397 N/A physical interaction ComPPI
FIS1 CREB3 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FIS1 NDUFA4 25348397 N/A physical interaction ComPPI
FIS1 COQ9 25348397 N/A physical interaction ComPPI
FIS1 NMES1 25348397 N/A physical interaction ComPPI
FIS1 TRIM25 25348397 N/A physical interaction ComPPI
FIS1 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
FIS1 LRRK2 22639965 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
FIS1 PIGP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 ABHD6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 FAM210B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 MMGT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 APH1A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 TMEM14B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 SCN3B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 SLC10A6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 TMPPE 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 FAM209A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 KCNJ6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 RNASEK 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 EBP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FIS1 COX6B1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
FIS1 NDUFAF8 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
FIS1 NDUFAF4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
UBB FIS1 25348397 N/A in vivo ComPPI
RPS27A FIS1 25348397 N/A in vivo ComPPI
HSCB FIS1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
FIS1 FIS1 14525934 14705031 N/A experimental interaction detection HPRD
DNM1 FIS1 16247028 17884824 23810512 27898060 N/A N/A OmniPath

Visualization