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GENE：FOXO3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FOXO3
FullNmae forkhead box O3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3821
EnsembleID ENSG00000118689
Uniprot O43524

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FOXO3 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FOXO3 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FOXO3 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FOXO3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FOXO3 GO:0000122,GO:0000122,GO:0000785,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0001228,GO:0003677,GO:0003700,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005759,GO:0005759,GO:0005829,GO:0005829,GO:0006357,GO:0006357,GO:0006390,GO:0006417,GO:0006915,GO:0008013,GO:0010508,GO:0014737,GO:0019901,GO:0030336,GO:0031490,GO:0032991,GO:0033209,GO:0034246,GO:0034599,GO:0042149,GO:0042594,GO:0043065,GO:0043525,GO:0043565,GO:0045591,GO:0045648,GO:0045893,GO:0045944,GO:0070542,GO:0090571,GO:1902895,GO:1990837

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FOXO3 hsa:2309 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04218 Cellular senescence - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04917 Prolactin signaling pathway - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa05131 Shigellosis - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa05213 Endometrial cancer - Homo sapiens (human)
FOXO3 hsa:2309 path:hsa05223 Non-small cell lung cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FOXO3 MMP9 10048576 16079281 16288288 16556862 17646672 19564415 22439866 26192618 8844971 interaction type N/A ACSN
FOXO3 MMP13 10048576 16079281 16288288 16556862 17646672 19564415 22439866 26192618 8844971 interaction type N/A ACSN
AKT1 FOXO3 10102273 11154281 11715018 11923280 15169778 17680028 18988627 20214616 20398329 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
HIF1A FOXO3 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 26192618 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622 interaction type N/A ACSN
MST1 FOXO3 12040186 16892067 19454690 20028971 23792360 26192618 interaction type N/A ACSN
SGK1 FOXO3 11154281 18570873 18925875 19584721 20338997 23331499 26192618 interaction type,stimulation N/A ACSN,SignaLink
MDM2 FOXO3 11715018 11779693 11923280 14761977 15024084 15084260 15169778 15876864 16307918 17110379 17158541 19321440 20679392 26192618 9450543 interaction type N/A ACSN
FOXO3 CHUK 15084260 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,gst pull down,in-gel kinase assay InnateDB
ERBIN FOXO3 15123239 23180781 physical association peptide array InnateDB
FOXO3 CFH 17558024 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT1 FOXO3 17558024 23180781 physical association anti tag coimmunoprecipitation InnateDB
IGFBP1 FOXO3 10102273 23180781 physical association electrophoretic mobility supershift assay InnateDB
YWHAB FOXO3 19940129 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOXO3 SHC1 18385518 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDKN2B FOXO3 19419955 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKB FOXO3 22531926 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKE FOXO3 22531926 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
PDGFRA FOXO3 22411791 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOXO3 FOXO3 12913110 26467481 up-regulates quantity by expression,transcriptional regulation N/A Signor
CTNNB1 FOXO3 15905404 21071413 23331499 stimulation N/A SignaLink,SignaLink
PPP4C FOXO3 16530049 23331499 stimulation N/A SignaLink
AKT3 FOXO3 15023346 23109003 inhibition N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR FOXO3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 FOXO3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FOXO3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FOXO3 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 FOXO3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR FOXO3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ABL1 FOXO3 15509806 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 FOXO3 19299143 trascriptional regulation,stimulation inferred by curator TFlink
RELA FOXO3 19299143 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 FOXO3 17558024 21841822 trascriptional regulation,stimulation inferred by curator TFlink
SIRT3 FOXO3 23665396 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FOXO3 19299143 trascriptional regulation,stimulation inferred by curator TFlink
TSC22D3 FOXO3 20018851 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 FOXO3 20371610 21304824 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00001CC379 FOXO3 19188590 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 FOXO3 20388878 rna interference,inhibition western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000153377 FOXO3 20388878 rna interference,inhibition western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001CC864 FOXO3 22084234 22095742 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000016FF9C FOXO3 21203424 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000153377 FOXO3 20388878 25416803 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000170CF4 FOXO3 20388878 25416803 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001CC379 FOXO3 19188590 23262295 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00000F4AC3 FOXO3 16822819 25416803 26540468 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS0000338542 FOXO3 19650740 20371610 21304824 23250986 23970205 25416803 27091996 28006785 28401267 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000016FF9C FOXO3 21203424 25369914 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001CC864 FOXO3 22084234 22095742 23824327 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 FOXO3 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EC1BE FOXO3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 FOXO3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 FOXO3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001D69F6 FOXO3 20371350 21572407 23603512 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000076995 FOXO3 24467486 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009262D FOXO3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 FOXO3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 FOXO3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA FOXO3 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000060B2B FOXO3 24376725 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002B7450 FOXO3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF FOXO3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 FOXO3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 FOXO3 24324762 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000355E82 FOXO3 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA FOXO3 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 FOXO3 20371350 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 FOXO3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001A405B FOXO3 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 FOXO3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000183BED FOXO3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 FOXO3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F507C FOXO3 25416803 26629010 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000001EB3 FOXO3 25416803 27541266 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000DDD35 FOXO3 25416803 25823655 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKAA1 FOXO3 22135298 phosphorylation N/A PhosphoSite
PRKAA2 FOXO3 22135298 phosphorylation N/A PhosphoSite
MAPK3 FOXO3 22135298 phosphorylation N/A PhosphoSite
SGK1 FOXO3 22135298 phosphorylation N/A PhosphoSite
IKBKE FOXO3 22135298 phosphorylation N/A PhosphoSite
MAPK14 FOXO3 22135298 phosphorylation N/A PhosphoSite
CHUK FOXO3 22135298 phosphorylation N/A PhosphoSite
MAPK1 FOXO3 22135298 phosphorylation N/A PhosphoSite
IKBKB FOXO3 22135298 phosphorylation N/A PhosphoSite
STK4 FOXO3 22135298 phosphorylation N/A PhosphoSite
PIM1 FOXO3 22135298 phosphorylation N/A PhosphoSite
MAPK8 FOXO3 22135298 phosphorylation N/A PhosphoSite
AKT1 FOXO3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
KPNA2 FOXO3 18687691 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PCNA FOXO3 25348397 N/A physical interaction ComPPI
PPP2R1A FOXO3 20110348 24234451 25348397 association coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
CDK6 FOXO3 22094256 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
YWHAG FOXO3 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD4 FOXO3 14525934 15084259 21532621 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
NLK FOXO3 25348397 N/A physical interaction ComPPI
CBY1 FOXO3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ERBIN FOXO3 25348397 N/A physical interaction ComPPI
FOXG1 FOXO3 14525934 15084259 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD1 FOXO3 25348397 N/A physical interaction ComPPI
MAPK1 FOXO3 25348397 N/A physical interaction ComPPI
PIM1 FOXO3 25348397 N/A anti bait coimmunoprecipitation ComPPI
RB1 FOXO3 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
HCFC1 FOXO3 21909281 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
AR FOXO3 18687691 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
CREBBP FOXO3 15126506 24234451 25348397 25609649 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
SMAD2 FOXO3 14525934 15084259 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
VDR FOXO3 25348397 N/A physical interaction ComPPI
EP300 FOXO3 11896584 14525934 24234451 25348397 25609649 association experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
SMAD3 FOXO3 14525934 15084259 21532621 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
HIF1A FOXO3 18268343 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
USP7 FOXO3 25348397 N/A physical interaction ComPPI
PNKP FOXO3 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
ARHGEF2 FOXO3 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
KPNB1 FOXO3 18687691 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NR1H3 FOXO3 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
YWHAB FOXO3 20562859 24234451 24255178 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ FOXO3 10102273 11864996 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
BTRC FOXO3 25348397 N/A physical interaction ComPPI
PLK1 FOXO3 25348397 N/A physical interaction ComPPI
IKBKB FOXO3 14525934 15084260 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
MYC FOXO3 18393360 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PPP2CB FOXO3 20110348 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
HNRNPL FOXO3 25348397 N/A physical interaction ComPPI
TERT FOXO3 25348397 N/A physical interaction ComPPI
MAPK6 FOXO3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPP2CA FOXO3 20110348 24234451 25348397 association tandem affinity purification ComPPI,IntAct
FANCD2 FOXO3 25348397 N/A physical interaction ComPPI
ATM FOXO3 25348397 N/A physical interaction ComPPI
XPO1 FOXO3 25348397 N/A physical interaction ComPPI
YWHAQ FOXO3 25348397 N/A physical interaction ComPPI
NR1H2 FOXO3 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MDM2 FOXO3 25348397 N/A physical interaction ComPPI
EGFR FOXO3 25348397 N/A physical interaction ComPPI
YWHAH FOXO3 17979178 20562859 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
YWHAE FOXO3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FKBP4 FOXO3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SKP2 FOXO3 25348397 N/A physical interaction ComPPI
TRRAP FOXO3 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
CTNNB1 FOXO3 24234451 25348397 29361949 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CHUK FOXO3 14525934 15084260 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
STK4 FOXO3 25348397 N/A physical interaction ComPPI
SIRT1 FOXO3 14525934 14976264 15126506 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,deacetylase assay,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PGK1 FOXO3 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SGK1 FOXO3 11154281 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ELAVL1 FOXO3 25348397 N/A physical interaction ComPPI
PTPA FOXO3 25348397 N/A physical interaction ComPPI
H2AX FOXO3 25348397 N/A physical interaction ComPPI
FOXO3 ESR1 11435445 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
FOXO3 AKT1 10102273 14525934 21621563 24234451 25241761 25348397 phosphorylation reaction,physical association experimental interaction detection,physical interaction,affinity technology,protein kinase assay,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
FOXO3 ATG101 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXO3 NIPSNAP2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FOXO3 SIRT3 18781224 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
FOXO3 BRCA1 25348397 N/A physical interaction ComPPI
FOXO3 RAD17 25348397 N/A physical interaction ComPPI
FOXO3 CDT1 25348397 N/A physical interaction ComPPI
FOXO3 CEP44 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FOXO3 TP53 14976264 24234451 25241761 25348397 physical association anti tag coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
FOXO3 PPP2R1B 25348397 N/A physical interaction ComPPI
FOXO3 RBL1 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
FOXO3 CDC27 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
FOXO3 AP5Z1 25348397 N/A physical interaction ComPPI
FOXO3 FOXK1 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
FOXO3 TAF5L 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
FOXO3 FOXM1 16809346 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FOXO3 HCFC2 21909281 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
FOXO3 FOXO6 24234451 25348397 25609649 association tandem affinity purification ComPPI,IntAct
FOXO3 FOXO3 20562859 24234451 physical association anti tag coimmunoprecipitation IntAct
MSTN FOXO3 24035192 24234451 association chromatin immunoprecipitation assay IntAct
FOXO3 TNFSF10 24234451 27451907 association chromatin immunoprecipitation assay IntAct
FOXO3 IRS2 24234451 27451907 association chromatin immunoprecipitation assay IntAct
PRKAA2 FOXO3 17711846 21329882 27898060 N/A N/A OmniPath
CTNNB1 FOXO3 15905404 17254970 27898060 stimulant N/A OmniPath
CSNK1A1 FOXO3 19188143 20110348 27898060 inhibition N/A OmniPath
CHUK FOXO3 15084260 27898060 inhibition N/A OmniPath
IKBKE FOXO3 22531926 23691078 27898060 inhibition N/A OmniPath
FOXO3 CDKN1B 14976264 15930121 27898060 inhibition,stimulant N/A OmniPath
FOXO3 ATG14 22992773 27898060 N/A N/A OmniPath
PPARGC1A FOXO3 19491292 27898060 inhibition N/A OmniPath
SIRT1 FOXO3 14976264 15126506 20733005 21713995 24003218 27898060 inhibition,stimulant N/A OmniPath
PIM1 FOXO3 18593906 27898060 inhibition N/A OmniPath
FOXO3 ATM 18344987 27898060 stimulant N/A OmniPath
AKT1 FOXO3 10102273 10910908 10995739 11154281 12506011 15060171 17522590 19188143 20068231 20643654 21329882 21775285 21777391 21798082 25241761 26376801 27898060 inhibition,stimulant N/A OmniPath
STK4 FOXO3 16751106 18394876 18985696 22898666 27898060 stimulant N/A OmniPath
PRKCQ FOXO3 11154281 11980723 27898060 N/A N/A OmniPath
STAT1 FOXO3 17558024 27898060 N/A N/A OmniPath
MAPK3 FOXO3 19282669 27898060 inhibition N/A OmniPath
MAPK14 FOXO3 22128155 27898060 stimulant N/A OmniPath
FOXO3 SHC1 18385518 27898060 N/A N/A OmniPath
SHC1 FOXO3 15930121 18385518 27898060 inhibition N/A OmniPath
FOXO3 FASLG 10102273 14976264 16865280 27898060 inhibition,stimulant N/A OmniPath
FOXO3 BCL2L11 11050388 12913110 27898060 inhibition,stimulant N/A OmniPath
FOXO3 SCP2 17522590 27898060 stimulant N/A OmniPath
AR FOXO3 18391971 27898060 inhibition N/A OmniPath
FOXO3 GADD45A 14976264 27898060 stimulant N/A OmniPath
MAPK1 FOXO3 18204439 27898060 inhibition N/A OmniPath
AKT3 FOXO3 19188143 27898060 inhibition N/A OmniPath
SGK1 FOXO3 10102273 11154281 18985696 20068231 27898060 inhibition,stimulant N/A OmniPath
PPP2CA FOXO3 20110348 27898060 stimulant N/A OmniPath
AKT2 FOXO3 19188143 27898060 inhibition N/A OmniPath
FOXO3 PINK1 19276113 27898060 stimulant N/A OmniPath
MAPK8 FOXO3 23857333 26470730 27898060 N/A N/A OmniPath
YWHAQ FOXO3 10102273 27898060 inhibition N/A OmniPath
MAPKAPK5 FOXO3 17711846 21329882 27898060 N/A N/A OmniPath
IKBKB FOXO3 15084260 19188143 22531926 23691078 25241761 27898060 inhibition N/A OmniPath
FOXO3 IKBKB 15084260 22531926 25241761 27898060 N/A N/A OmniPath
FOXO3 PDGFRA 22411791 27898060 N/A N/A OmniPath
FOXO3 YWHAB 19940129 20562859 24255178 27898060 N/A N/A OmniPath
PPP4C FOXO3 16530049 27898060 stimulant N/A OmniPath
ERBIN FOXO3 15123239 27898060 N/A N/A OmniPath
PRKAA1 FOXO3 17711846 22474372 27898060 stimulant N/A OmniPath
DYRK1A FOXO3 19188143 27898060 inhibition N/A OmniPath
SGK3 FOXO3 11154281 27898060 inhibition N/A OmniPath
SGK2 FOXO3 11154281 27898060 inhibition N/A OmniPath

Visualization










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