Gene Information gene info

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GENE：GCLM

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GCLM
FullNmae glutamate-cysteine ligase modifier subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4312
EnsembleID ENSG00000023909
Uniprot P48507

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GCLM mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GCLM mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GCLM immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GCLM ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GCLM ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GCLM autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GCLM apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GCLM apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GCLM cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
GCLM GO:0004357,GO:0005515,GO:0005829,GO:0005829,GO:0006534,GO:0006536,GO:0006750,GO:0006750,GO:0006750,GO:0006750,GO:0006979,GO:0007584,GO:0008637,GO:0009410,GO:0014823,GO:0017109,GO:0017109,GO:0030234,GO:0035226,GO:0035229,GO:0035729,GO:0035733,GO:0043524,GO:0044344,GO:0044752,GO:0044877,GO:0051409,GO:0051900,GO:0071333,GO:0071372,GO:0097069,GO:0097746,GO:1990830,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GCLM hsa:2730 path:hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
GCLM hsa:2730 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
GCLM hsa:2730 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GCLM hsa:2730 path:hsa01240 Biosynthesis of cofactors - Homo sapiens (human)
GCLM hsa:2730 path:hsa04216 Ferroptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
JUN GCLM 19666106 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFE2L2 GCLM 19666106 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR GCLM 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GCLM 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
JUND GCLM 10441483 trascriptional regulation,stimulation electrophoretic mobility shift assay TFlink
FOXP3 GCLM 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
NFE2L2 GCLM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 GCLM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA GCLM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF GCLM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GCLM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GCLM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 GCLM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GCLM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 GCLM N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 GCLM N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000171CD1 GCLM 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005D986D GCLM 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 GCLM 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005651EE GCLM 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002D349B GCLM 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC GCLM 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000024DFCE GCLM 25353619 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
GCLC GCLM 25361965 interaction type N/A PTMCode2
GCLM GCLC 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GLRX3 GCLM 25348397 N/A physical interaction ComPPI
CALM1 GCLM 25348397 N/A two hybrid,physical interaction ComPPI
PRKCA GCLM 25348397 N/A physical interaction ComPPI
CUL3 GCLM 25348397 N/A physical interaction ComPPI
PLAUR GCLM 25348397 N/A physical interaction ComPPI
NAGK GCLM 25348397 N/A physical interaction ComPPI
ARF6 GCLM 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EGFR GCLM 25348397 N/A physical interaction ComPPI
TNFRSF14 GCLM 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
GNAI2 GCLM 25348397 N/A physical interaction ComPPI
IRF7 GCLM 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RRP1B GCLM 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
SORD GCLM 25348397 N/A physical interaction ComPPI
MCC GCLM 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRPV5 GCLM 25348397 N/A physical interaction ComPPI
UROS GCLM 25348397 N/A physical interaction ComPPI
CPNE3 GCLM 25348397 N/A physical interaction ComPPI
PHLDA3 GCLM 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
OTUB1 GCLM 24234451 25348397 26752685 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FTSJ1 GCLM 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PARP12 GCLM 25348397 N/A physical interaction ComPPI
GCLC GCLM 25348397 N/A physical interaction ComPPI
GCLM STOX1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
GCLM DNA2 25348397 N/A physical interaction ComPPI
GCLM CBWD1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HSCB GCLM 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
CALM2 GCLM 21988832 24234451 physical association two hybrid array IntAct
NFE2L2 GCLM 16485034 18535259 19808663 27898060 stimulant N/A OmniPath

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