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GENE：GPX1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GPX1
FullNmae glutathione peroxidase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4553
EnsembleID ENSG00000233276
Uniprot P07203

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GPX1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GPX1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GPX1 GO:0001659,GO:0001885,GO:0002862,GO:0004602,GO:0004602,GO:0005515,GO:0005737,GO:0005739,GO:0005739,GO:0005759,GO:0005829,GO:0005829,GO:0005829,GO:0006641,GO:0006749,GO:0006749,GO:0007605,GO:0008631,GO:0009410,GO:0009609,GO:0009650,GO:0009725,GO:0010269,GO:0010269,GO:0010332,GO:0017124,GO:0019369,GO:0019372,GO:0032355,GO:0033194,GO:0033197,GO:0033599,GO:0034599,GO:0035094,GO:0040029,GO:0042311,GO:0042542,GO:0042542,GO:0042744,GO:0042744,GO:0043154,GO:0043403,GO:0043534,GO:0045444,GO:0045445,GO:0045454,GO:0047066,GO:0048144,GO:0048741,GO:0051402,GO:0051450,GO:0051593,GO:0051702,GO:0051897,GO:0060047,GO:0060055,GO:0061136,GO:0071333,GO:0090201,GO:0097413,GO:0098869,GO:1902042,GO:1902176,GO:1902905

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GPX1 hsa:2876 path:hsa00480 Glutathione metabolism - Homo sapiens (human)
GPX1 hsa:2876 path:hsa01100 Metabolic pathways - Homo sapiens (human)
GPX1 hsa:2876 path:hsa04918 Thyroid hormone synthesis - Homo sapiens (human)
GPX1 hsa:2876 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
GPX1 hsa:2876 path:hsa05016 Huntington disease - Homo sapiens (human)
GPX1 hsa:2876 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR GPX1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GPX1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 GPX1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GPX1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 GPX1 16980608 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA GPX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 GPX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR GPX1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2C GPX1 22964634 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001A7F58 GPX1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000017EA6A GPX1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002971AB GPX1 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004818BD GPX1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005BB0FD GPX1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075BC91 GPX1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00007455B8 GPX1 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ABL1 GPX1 22135298 phosphorylation N/A PhosphoSite
ABL2 GPX1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CEP19 GPX1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
TXN GPX1 25348397 N/A physical interaction ComPPI
DCTN1 GPX1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MAPK6 GPX1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GPX1 ABL2 12893824 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GPX1 ABL1 12893824 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
GPX1 SELENBP1 20530237 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GPX1 EXOSC2 25348397 N/A physical interaction ComPPI
GPX1 KARS1 25348397 N/A physical interaction ComPPI
GPX1 FAM9B 25348397 N/A physical interaction ComPPI
GPX1 CEP152 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GPX1 CEP128 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GPX1 CEP164 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GPX1 RPGRIP1L 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GPX1 CENPJ 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
GPX1 SIRT4 24234451 25348397 25525879 association anti tag coimmunoprecipitation ComPPI,IntAct
HSCB GPX1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
ABL2 GPX1 12893824 20841568 27898060 stimulant N/A OmniPath
TP53 GPX1 18431400 27898060 stimulant N/A OmniPath
ABL1 GPX1 12893824 20841568 27898060 stimulant N/A OmniPath

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