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GENE：GSDME

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol GSDME
FullNmae gasdermin E
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2810
EnsembleID ENSG00000105928
Uniprot O60443

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
GSDME pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSDME pyroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
GSDME immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSDME apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
GSDME apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
GSDME GO:0002839,GO:0005515,GO:0005546,GO:0005737,GO:0005829,GO:0005829,GO:0005886,GO:0007605,GO:0008285,GO:0012501,GO:0016020,GO:0022829,GO:0042491,GO:0043410,GO:0055085,GO:0070269,GO:0071356,GO:0098586,GO:1901612,GO:2001244

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
GSDME hsa:1687 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR GSDME 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 GSDME 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 GSDME 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 GSDME 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C GSDME 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CTCF GSDME 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 GSDME 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS GSDME 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A GSDME 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 GSDME 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 GSDME 19088304 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
SNW1 GSDME 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L GSDME 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TIFA GSDME 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NTRK1 GSDME 25348397 N/A physical interaction ComPPI
PLEC GSDME 25348397 N/A physical interaction ComPPI
ITGB1BP1 GSDME 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
EPHA1 GSDME 25348397 N/A physical interaction ComPPI
EGFR GSDME 25348397 N/A physical interaction ComPPI
BIRC6 GSDME 25348397 N/A physical interaction ComPPI
PTN GSDME 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MUL1 GSDME 25348397 N/A physical interaction ComPPI
GSDME RPS3 25348397 N/A physical interaction ComPPI

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