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GENE：HINT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HINT1
FullNmae histidine triad nucleotide binding protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4912
EnsembleID ENSG00000169567
Uniprot P49773

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HINT1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HINT1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HINT1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HINT1 GO:0000118,GO:0000166,GO:0005080,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005856,GO:0005886,GO:0006355,GO:0007165,GO:0009154,GO:0009154,GO:0016787,GO:0016787,GO:0016926,GO:0016929,GO:0043530,GO:0043530,GO:0050850,GO:0070062,GO:0072332

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HINT1 RUVBL1 16014379 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
HINT1 RUVBL2 16014379 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
HINT1 HINT1 16014379 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 HINT1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HINT1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HINT1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC HINT1 12747840 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 HINT1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 HINT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HINT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HINT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HINT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HINT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HINT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HINT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 HINT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE HINT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB HINT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000027464B HINT1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000004203C HINT1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000046CDA6 HINT1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AB32B HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E780 HINT1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PIN1 HINT1 25348397 N/A physical interaction ComPPI
PPIB HINT1 25348397 N/A physical interaction ComPPI
FABP3 HINT1 25348397 N/A physical interaction ComPPI
NUTF2 HINT1 25348397 N/A physical interaction ComPPI
FKBP1A HINT1 25348397 N/A physical interaction ComPPI
SP1 HINT1 25348397 N/A physical interaction ComPPI
CDC16 HINT1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ARHGDIA HINT1 25348397 N/A physical interaction ComPPI
U2AF2 HINT1 25348397 N/A physical interaction ComPPI
RBX1 HINT1 25348397 N/A physical interaction ComPPI
DUT HINT1 25348397 N/A physical interaction ComPPI
ENO1 HINT1 25348397 N/A physical interaction ComPPI
BTRC HINT1 25348397 26520111 27898060 N/A physical interaction ComPPI,OmniPath
RUVBL1 HINT1 25348397 N/A physical interaction ComPPI
STIP1 HINT1 25348397 N/A physical interaction ComPPI
SIN3A HINT1 25348397 N/A physical interaction ComPPI
TXN HINT1 25348397 N/A physical interaction ComPPI
TRIM29 HINT1 14525934 24234451 25348397 7644499 physical association two hybrid,experimental interaction detection,in vitro ComPPI,HPRD,IntAct
TAGLN HINT1 25348397 N/A physical interaction ComPPI
EWSR1 HINT1 25348397 N/A physical interaction ComPPI
AKR1B1 HINT1 25348397 N/A physical interaction ComPPI
FKBP1B HINT1 25348397 N/A physical interaction ComPPI
SPR HINT1 25348397 N/A physical interaction ComPPI
VHL HINT1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FKBP2 HINT1 25348397 N/A physical interaction ComPPI
CDC34 HINT1 25348397 N/A physical interaction ComPPI
ACTL6A HINT1 25348397 N/A physical interaction ComPPI
CTNNB1 HINT1 25348397 N/A physical interaction ComPPI
PRDX6 HINT1 25348397 N/A physical interaction ComPPI
CDK9 HINT1 25348397 N/A physical interaction ComPPI
HDAC9 HINT1 25348397 N/A physical interaction ComPPI
HDAC7 HINT1 25348397 N/A physical interaction ComPPI
HSPE1 HINT1 25348397 N/A physical interaction ComPPI
FABP5 HINT1 25348397 N/A physical interaction ComPPI
TRIM25 HINT1 25348397 N/A physical interaction ComPPI
RAE1 HINT1 25348397 N/A physical interaction ComPPI
PARK7 HINT1 25348397 N/A physical interaction ComPPI
SOD1 HINT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
UBE2V1 HINT1 25348397 N/A physical interaction ComPPI
UCHL3 HINT1 25348397 N/A physical interaction ComPPI
PFDN2 HINT1 25348397 N/A physical interaction ComPPI
RUVBL2 HINT1 25348397 N/A physical interaction ComPPI
MIF HINT1 25348397 N/A physical interaction ComPPI
HINT1 KAT5 25348397 N/A physical interaction ComPPI
HINT1 MITF 25348397 N/A physical interaction ComPPI
HINT1 DHX36 25348397 N/A physical interaction ComPPI
HINT1 LEF1 25348397 N/A physical interaction ComPPI
HINT1 UNK 25348397 N/A physical interaction ComPPI
HINT1 AKR1B10 25348397 N/A physical interaction ComPPI
HINT1 AKR1B15 25348397 N/A physical interaction ComPPI
HINT1 ENO2 25348397 N/A physical interaction ComPPI
HINT1 ENO3 25348397 N/A physical interaction ComPPI
HINT1 FABP5P3 25348397 N/A physical interaction ComPPI
HINT1 FABP7 25348397 N/A physical interaction ComPPI
HINT1 GPX4 25348397 N/A physical interaction ComPPI
HINT1 GSTO2 25348397 N/A physical interaction ComPPI
HINT1 GSTT1 25348397 N/A physical interaction ComPPI
HINT1 FKBP7 25348397 N/A physical interaction ComPPI
HINT1 HSPA4L 25348397 N/A physical interaction ComPPI
HINT1 MTAP 25348397 N/A physical interaction ComPPI
HINT1 OXCT1 25348397 N/A physical interaction ComPPI
HINT1 PTGR1 25348397 N/A physical interaction ComPPI
HINT1 RGN 25348397 N/A physical interaction ComPPI
HINT1 TKT 25348397 N/A physical interaction ComPPI
HINT1 NME2 25348397 N/A physical interaction ComPPI
HINT1 PRDX2 25348397 N/A physical interaction ComPPI
HINT1 PRDX5 25348397 N/A physical interaction ComPPI
HINT1 TAGLN2 25348397 N/A physical interaction ComPPI
HINT1 TAGLN3 25348397 N/A physical interaction ComPPI
HINT1 PEDS1 25348397 N/A physical interaction ComPPI
HINT1 UFC1 25348397 N/A physical interaction ComPPI
HINT1 OFD1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HINT1 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HINT1 STIL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HINT1 SNX24 25348397 N/A physical interaction ComPPI
HINT1 GNL1 25348397 N/A physical interaction ComPPI
HINT1 HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HINT1 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
SNRNP27 HINT1 25348397 N/A physical interaction ComPPI
PMP2 HINT1 25348397 N/A physical interaction ComPPI
HINT1 HINT1 14525934 22869114 24234451 8643579 9323207 N/A experimental interaction detection,x-ray crystallography HPRD,IntAct

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