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GENE：HIP1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HIP1
FullNmae huntingtin interacting protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4913
EnsembleID ENSG00000127946
Uniprot O00291

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HIP1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HIP1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HIP1 GO:0005154,GO:0005200,GO:0005515,GO:0005634,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0006897,GO:0006915,GO:0006919,GO:0006919,GO:0007015,GO:0016020,GO:0030100,GO:0030136,GO:0030136,GO:0030154,GO:0030276,GO:0030665,GO:0032051,GO:0032051,GO:0032266,GO:0035091,GO:0035254,GO:0035612,GO:0035615,GO:0035615,GO:0042734,GO:0042803,GO:0042981,GO:0043231,GO:0043325,GO:0043325,GO:0045211,GO:0045742,GO:0046982,GO:0048260,GO:0048268,GO:0048268,GO:0050821,GO:0051015,GO:0051015,GO:0051897,GO:0080025,GO:0080025,GO:0097190,GO:0098685,GO:0098793,GO:0098793,GO:0098794,GO:0098978,GO:0099149,GO:0099171,GO:0099637,GO:2000588

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HIP1 hsa:3092 path:hsa05016 Huntington disease - Homo sapiens (human)
HIP1 hsa:3092 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HIP1 IFT57 11788820 26192618 association N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR HIP1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 HIP1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 HIP1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HIP1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HIP1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 HIP1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 HIP1 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C HIP1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 HIP1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A HIP1 11517213 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000075A513 HIP1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 HIP1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F HIP1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001A6D0C HIP1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 HIP1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA HIP1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 HIP1 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C HIP1 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 HIP1 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 HIP1 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 HIP1 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 HIP1 22100165 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 HIP1 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040780F HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075BC91 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000512C88 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000453664 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000055128B HIP1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A HIP1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 HIP1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 HIP1 23313552 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 HIP1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
HIP1 HTT 25361965 interaction type N/A PTMCode2
HTT HIP1 25361965 interaction type N/A PTMCode2
HIP1 CASP8 25361965 interaction type N/A PTMCode2
CASP8 HIP1 25361965 interaction type N/A PTMCode2
HIP1 AP2A1 25361965 interaction type N/A PTMCode2
AP2A1 HIP1 25361965 interaction type N/A PTMCode2
HIP1 TFAP2A 25361965 interaction type N/A PTMCode2
TFAP2A HIP1 25361965 interaction type N/A PTMCode2
CASP9 HIP1 25361965 interaction type N/A PTMCode2
HIP1 CASP9 25361965 interaction type N/A PTMCode2
CLTA HIP1 25361965 interaction type N/A PTMCode2
HIP1 CLTA 25361965 interaction type N/A PTMCode2
IFT57 HIP1 25361965 interaction type N/A PTMCode2
HIP1 IFT57 25361965 interaction type N/A PTMCode2
CASP3 HIP1 25361965 interaction type N/A PTMCode2
HIP1 CASP3 25361965 interaction type N/A PTMCode2
AP1B1 HIP1 25361965 interaction type N/A PTMCode2
HIP1 AP1B1 25361965 interaction type N/A PTMCode2
CLTC HIP1 25361965 interaction type N/A PTMCode2
HIP1 CLTC 25361965 interaction type N/A PTMCode2
CLTB HIP1 25361965 interaction type N/A PTMCode2
HIP1 CLTB 25361965 interaction type N/A PTMCode2
HIP1R HIP1 25361965 interaction type N/A PTMCode2
HIP1 HIP1R 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SYT17 HIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CASP9 HIP1 14525934 16979168 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CFAP53 HIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPRM HIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
REL HIP1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CASP3 HIP1 14525934 16979168 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CPNE2 HIP1 25348397 N/A physical interaction ComPPI
UBE2N HIP1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
NTRK1 HIP1 25348397 N/A physical interaction ComPPI
TFAP2A HIP1 11604514 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGB3BP HIP1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CASP8 HIP1 11788820 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK6 HIP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
EIF6 HIP1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CLTC HIP1 11517213 11532990 11577110 11604514 14525934 15383276 22820750 24234451 25241761 25348397 26496610 27898060 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct,OmniPath
AP2A1 HIP1 11517213 24234451 25348397 colocalization,physical association pull down,imaging technique,in vitro,in vivo ComPPI,IntAct
AP2B1 HIP1 25348397 N/A two hybrid ComPPI
DVL2 HIP1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
ITSN1 HIP1 25348397 N/A physical interaction ComPPI
EHHADH HIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EGFR HIP1 25348397 N/A physical interaction ComPPI
HTT HIP1 11063258 14525934 15383276 17500595 22835334 24234451 25348397 9147654 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
VCAM1 HIP1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
RAD23B HIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBA1 HIP1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
APAF1 HIP1 14525934 16979168 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SMURF1 HIP1 25348397 N/A physical interaction ComPPI
TRIM25 HIP1 25348397 N/A physical interaction ComPPI
GLS2 HIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GAK HIP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HIP1 IFT57 11788820 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
HIP1 CLTA 11889126 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HIP1 CLTB 1189126 14525934 15533940 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
HIP1 RPS10 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HIP1 PFDN1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
HIP1 NECAP1 14525934 17762867 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
HIP1 HIP1R 11063258 11889126 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
HIP1 BFAR 25348397 N/A physical interaction ComPPI
HIP1 FBXO25 25348397 N/A physical interaction ComPPI
HIP1 DAZAP2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
HIP1 MAP3K1 25348397 N/A physical interaction ComPPI
HIP1 DEUP1 25348397 N/A physical interaction ComPPI
HIP1 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
HIP1 MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HIP1 GTSE1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HIP1 CLTCL1 11517213 24234451 25348397 colocalization,physical association filter binding,pull down,imaging technique ComPPI,IntAct
HIP1 UBE2V1 24234451 25260751 25348397 ubiquitination reaction ubiquitinase assay ComPPI,IntAct
HIP1 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HIP1 TCEA2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HIP1 CYRIB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HIP1 LITAF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HIP1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
HIP1 HIP1 11063258 11517213 14525934 15533940 24234451 25416956 physical association experimental interaction detection,two hybrid array,two hybrid HPRD,IntAct
PLEC HIP1 24234451 30021884 physical association cross-linking study IntAct

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