Gene Information gene info

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GENE：HMGB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HMGB2
FullNmae high mobility group box 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5000
EnsembleID ENSG00000164104
Uniprot P26583

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HMGB2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGB2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HMGB2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HMGB2 GO:0000122,GO:0000400,GO:0000785,GO:0000793,GO:0000976,GO:0000987,GO:0001938,GO:0002437,GO:0003677,GO:0003684,GO:0003690,GO:0003697,GO:0003713,GO:0003723,GO:0005515,GO:0005615,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0006265,GO:0006303,GO:0006325,GO:0006334,GO:0006357,GO:0006357,GO:0007289,GO:0008134,GO:0008301,GO:0008301,GO:0008584,GO:0008625,GO:0010629,GO:0019904,GO:0032075,GO:0032392,GO:0032496,GO:0032728,GO:0032991,GO:0033151,GO:0042056,GO:0043388,GO:0044378,GO:0045087,GO:0045089,GO:0045648,GO:0045654,GO:0045892,GO:0045893,GO:0045944,GO:0048471,GO:0048545,GO:0050767,GO:0050786,GO:0050829,GO:0050830,GO:0050918,GO:0060326,GO:0071222,GO:0072091,GO:0097100,GO:0140297,GO:1902042

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HMGB2 GFI1 19506020 23180781 physical association two hybrid InnateDB
CDK2 HMGB2 21319273 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP HMGB2 21832049 23180781 physical association protein array InnateDB
HMGB2 UBB 23180781 24816145 ubiquitination reaction ubiquitinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 HMGB2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 HMGB2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 HMGB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HMGB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 HMGB2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 HMGB2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 HMGB2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 HMGB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA HMGB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 HMGB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HMGB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 HMGB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS HMGB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 HMGB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB HMGB2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000CBE63 HMGB2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000285DCB HMGB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000B0E50 HMGB2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002ECEE4 HMGB2 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000157F5 HMGB2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000029979D HMGB2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000183BED HMGB2 20371350 23592263 25416803 25996293 26701625 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00001CC864 HMGB2 20371350 23592263 23986579 25416803 26701625 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS000075B538 HMGB2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000345DEB HMGB2 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000007340 HMGB2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000292B1 HMGB2 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075AB0E HMGB2 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000057FDB8 HMGB2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002E628F HMGB2 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 HMGB2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000315338 HMGB2 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002DD349 HMGB2 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000427B68 HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000EE7F0 HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 HMGB2 21572407 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000001C659 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001EB9FC HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000023BE29 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000939AF HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000260A3A HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000045DBD HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000065FDF HMGB2 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TFAP4 HMGB2 25348397 N/A physical interaction ComPPI
TSNAX HMGB2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EIF1B HMGB2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CEP19 HMGB2 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LDHB HMGB2 25348397 N/A physical interaction ComPPI
SET HMGB2 11909973 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TRAF6 HMGB2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CHAF1A HMGB2 25348397 N/A physical interaction ComPPI
HMGB2 GZMA 11909973 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HMGB2 POU2F1 25348397 N/A in vitro,in vivo ComPPI
HMGB2 POU2F2 14525934 25348397 7720710 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HMGB2 POU5F1 11099378 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HMGB2 RAG1 10490593 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
HMGB2 PRKDC 14525934 25348397 9722660 N/A experimental interaction detection,in vitro ComPPI,HPRD
HMGB2 POU3F1 14525934 25348397 7720710 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
HMGB2 PGR 14525934 25348397 9671457 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HMGB2 CSNK1A1 12062430 14525934 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique ComPPI,HPRD,IntAct
HMGB2 NR3C1 25348397 N/A physical interaction ComPPI
HMGB2 AR 25348397 N/A physical interaction ComPPI
HMGB2 CREBBP 25348397 N/A physical interaction ComPPI
HMGB2 HMGB1 25348397 N/A physical interaction ComPPI
HMGB2 ELAVL1 25348397 N/A physical interaction ComPPI
HMGB2 CDK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGB2 APP 25348397 N/A physical interaction ComPPI
HMGB2 SCAF8 25348397 N/A physical interaction ComPPI
HMGB2 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
HMGB2 GZMK 25348397 N/A physical interaction ComPPI
HMGB2 HMGA1 25348397 N/A filter binding,physical interaction ComPPI
HMGB2 PGD 25348397 N/A physical interaction ComPPI
HMGB2 YWHAG 25348397 N/A physical interaction ComPPI
HMGB2 PKNOX1 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HMGB2 SHMT2 25348397 N/A physical interaction ComPPI
HMGB2 MOV10 25348397 N/A physical interaction ComPPI
HMGB2 NXF1 25348397 N/A physical interaction ComPPI
HMGB2 EED 25348397 N/A physical interaction ComPPI
HMGB2 SSRP1 25348397 N/A physical interaction ComPPI
HMGB2 SUPT16H 25348397 N/A physical interaction ComPPI
HMGB2 NTRK1 25348397 N/A physical interaction ComPPI
HMGB2 H2BC11 25348397 N/A physical interaction ComPPI
HMGB2 H2BC4 25348397 N/A physical interaction ComPPI
HMGB2 FLNA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGB2 MYO1C 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGB2 SYNPO 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGB2 MYO18A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGB2 CFAP97 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HMGB2 U2AF2 25348397 N/A physical interaction ComPPI
HMGB2 PSMD12 25348397 N/A physical interaction ComPPI
HMGB2 EGFR 25348397 N/A physical interaction ComPPI
HMGB2 NFKB1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
HMGB2 VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
HMGB2 OTUB1 24234451 25348397 26752685 association anti tag coimmunoprecipitation ComPPI,IntAct
HMGB2 PHOSPHO1 24234451 25348397 28330616 association pull down ComPPI,IntAct
H3C1 HMGB2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CKB HMGB2 25348397 N/A physical interaction ComPPI
HMGB2 APEX1 12524539 14525934 N/A experimental interaction detection HPRD
TP53 HMGB2 11748232 14525934 N/A experimental interaction detection HPRD
SMARCB1 HMGB2 24234451 30108113 association proximity-dependent biotin identification IntAct
HMGB2 CBLB 24234451 30021884 physical association cross-linking study IntAct
DZIP1 HMGB2 24234451 30021884 physical association cross-linking study IntAct
HMGB2 OTOF 24234451 30021884 physical association cross-linking study IntAct
HMGB2 SYVN1 11390656 16270032 19324879 19394298 20005842 27898060 N/A N/A OmniPath
HMGB2 NSG1 16270032 23306196 27898060 N/A N/A OmniPath
GZMA HMGB2 11909973 17008916 27898060 inhibition N/A OmniPath

Visualization










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