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GENE：HRK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HRK
FullNmae harakiri, BCL2 interacting protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5185
EnsembleID ENSG00000135116
Uniprot O00198

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HRK apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HRK apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HRK GO:0005515,GO:0005739,GO:0005739,GO:0006915,GO:0016020,GO:0031334,GO:0043065,GO:0043065,GO:0090200

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HRK hsa:8739 path:hsa04210 Apoptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 HRK 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 HRK 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
CEBPA HRK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF HRK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 HRK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HRK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HRK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 HRK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 HRK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 HRK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 HRK 23090478 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002E0524 HRK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005DEC41 HRK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 HRK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 HRK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB HRK 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001CC4BD HRK 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 HRK 22291592 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 HRK 23313552 23824327 24906430 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS000076B539 HRK 22927820 23313552 23824327 24906430 25416803 27418678 28735896 mrna cleavage,inhibition clip TarBase
URS0000134ADC HRK 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000044FD7 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000321A1A HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001CE046 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CEB74 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004BC299 HRK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 HRK 22927820 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 HRK 25416803 28097098 mrna cleavage,inhibition array technology TarBase
URS00002CCA6E HRK 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
BCL2L2 HRK 14525934 15694340 24234451 25348397 N/A experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
BCL2L1 HRK 10075695 14525934 14596824 16697956 24234451 25348397 9130713 N/A experimental interaction detection,fluorescence polarization spectroscopy,scintillation proximity assay,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BAD HRK 11483855 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
MCL1 HRK 15031724 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
C1QBP HRK 14525934 15031724 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,fluorescence microscopy,in vitro,two hybrid ComPPI,HPRD,IntAct
BCL2A1 HRK 14525934 15694340 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BCL2 HRK 10075695 14525934 25348397 9130713 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
HRK ELAVL1 25348397 N/A physical interaction ComPPI
HRK BCL2L1 10075695 14596824 15721256 16697956 27898060 9130713 inhibition N/A OmniPath
HRK BCL2 10075695 15694340 27898060 9130713 inhibition N/A OmniPath

Visualization










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