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GENE：HTRA2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol HTRA2
FullNmae HtrA serine peptidase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14348
EnsembleID ENSG00000115317
Uniprot O43464

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
HTRA2 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HTRA2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HTRA2 autophagy 36758105 We performed a structure-function analysis of BIRC6 in complex with caspase-9, HTRA2, SMAC, and LC3B, which are critical apoptosis and autophagy proteins. retulator signature
HTRA2 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
HTRA2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
HTRA2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
HTRA2 GO:0000785,GO:0004252,GO:0004252,GO:0004252,GO:0005515,GO:0005634,GO:0005739,GO:0005739,GO:0005739,GO:0005739,GO:0005758,GO:0005783,GO:0005789,GO:0005829,GO:0005856,GO:0006508,GO:0006508,GO:0006508,GO:0006508,GO:0006672,GO:0007005,GO:0007628,GO:0008233,GO:0008233,GO:0008236,GO:0008236,GO:0008630,GO:0009635,GO:0009898,GO:0010822,GO:0012501,GO:0012501,GO:0016020,GO:0016540,GO:0019742,GO:0030163,GO:0030900,GO:0031966,GO:0034599,GO:0034599,GO:0034605,GO:0035458,GO:0035631,GO:0040014,GO:0042802,GO:0043065,GO:0043065,GO:0043065,GO:0043280,GO:0043280,GO:0043524,GO:0045786,GO:0048666,GO:0051082,GO:0051402,GO:0071300,GO:0071363,GO:0097194,GO:1902176,GO:1903146,GO:1903955,GO:1904924,GO:1905370,GO:2001241,GO:2001269

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
HTRA2 hsa:27429 path:hsa04210 Apoptosis - Homo sapiens (human)
HTRA2 hsa:27429 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
HTRA2 hsa:27429 path:hsa05012 Parkinson disease - Homo sapiens (human)
HTRA2 hsa:27429 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HTRA2 HAX1 11803371 15371414 23070005 26192618 interaction type N/A ACSN
HTRA2 BIRC6 10521396 11583623 11803371 12815069 12835328 15781261 19935698 20125124 23070005 26192618 interaction type N/A ACSN
HTRA2 XIAP 10521396 11583623 11801603 11803371 12815069 12835328 12865429 15200957 15201285 15781261 17311912 19935698 20125124 23070005 23180781 26192618 interaction type,biochemical,physical association affinity chromatography technology,anti tag coimmunoprecipitation,fluorescence polarization spectroscopy,gst pull down,mutation analysis,protease assay ACSN,InnateDB
HTRA2 CAPN2 10521396 11583623 11803371 12815069 12835328 15781261 19935698 20125124 23070005 26192618 interaction type N/A ACSN
HTRA2 RIPK1 10521396 11583623 11803371 12815069 12835328 15781261 19935698 20125124 23070005 26192618 interaction type N/A ACSN
BIRC6 HTRA2 15300255 23180781 physical association anti tag coimmunoprecipitation InnateDB
HTRA2 BIRC2 11606597 12865429 23180781 physical association affinity chromatography technology InnateDB
HTRA2 BIRC3 11606597 12865429 23180781 physical association affinity chromatography technology InnateDB

Source Target Pmid Interactiontype Methods Database
GATA1 HTRA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 HTRA2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 HTRA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 HTRA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 HTRA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 HTRA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 HTRA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A HTRA2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 HTRA2 21486948 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EC1BE HTRA2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MAPK12 HTRA2 22135298 phosphorylation N/A PhosphoSite
CDK5 HTRA2 22135298 phosphorylation N/A PhosphoSite
AKT2 HTRA2 22135298 phosphorylation N/A PhosphoSite
AKT1 HTRA2 22135298 phosphorylation N/A PhosphoSite
HTRA2 BIRC3 25361965 interaction type N/A PTMCode2
BIRC3 HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 DIABLO 25361965 interaction type N/A PTMCode2
DIABLO HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 APP 25361965 interaction type N/A PTMCode2
APP HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 CSN2 25361965 interaction type N/A PTMCode2
CSN2 HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 XIAP 25361965 interaction type N/A PTMCode2
XIAP HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 BIRC6 25361965 interaction type N/A PTMCode2
BIRC6 HTRA2 25361965 interaction type N/A PTMCode2
PAG1 HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 PAG1 25361965 interaction type N/A PTMCode2
MAPK14 HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 MAPK14 25361965 interaction type N/A PTMCode2
BIRC2 HTRA2 25361965 interaction type N/A PTMCode2
HTRA2 BIRC2 25361965 interaction type N/A PTMCode2
HTRA2 HTRA2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
VPS4B HTRA2 25348397 N/A physical interaction ComPPI
VIM HTRA2 25348397 N/A physical interaction ComPPI
TUBB HTRA2 25348397 N/A physical interaction ComPPI
VCP HTRA2 25348397 N/A physical interaction ComPPI
XIAP HTRA2 11583623 11602612 11604410 11606597 11801603 11803371 14525934 24234451 24698088 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,fluorescence polarization spectroscopy,pull down,surface plasmon resonance,physical interaction,in vitro ComPPI,HPRD,IntAct
BIRC8 HTRA2 25348397 N/A physical interaction ComPPI
NDUFAF4 HTRA2 25348397 N/A physical interaction ComPPI
PAK5 HTRA2 25348397 N/A physical interaction ComPPI
PAG1 HTRA2 14525934 16413409 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,OmniPath
DSTN HTRA2 25348397 N/A physical interaction ComPPI
MAPK3 HTRA2 25348397 N/A physical interaction ComPPI
USP7 HTRA2 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
EIF4G1 HTRA2 25348397 N/A physical interaction ComPPI
MAPK14 HTRA2 10644717 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
NIT1 HTRA2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
APC HTRA2 25348397 N/A physical interaction ComPPI
PIR HTRA2 25348397 N/A physical interaction ComPPI
HAX1 HTRA2 25348397 N/A physical interaction ComPPI
MAPK13 HTRA2 25348397 N/A physical interaction ComPPI
EEF1A1 HTRA2 25348397 N/A physical interaction ComPPI
PEA15 HTRA2 14525934 15328349 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CAD HTRA2 25348397 N/A physical interaction ComPPI
RMND5A HTRA2 25348397 N/A physical interaction ComPPI
TRAF1 HTRA2 25348397 N/A physical interaction ComPPI
TRAF2 HTRA2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TUBA1A HTRA2 25348397 N/A physical interaction ComPPI
MAPK12 HTRA2 25348397 N/A physical interaction ComPPI
TRIM28 HTRA2 25348397 N/A physical interaction ComPPI
CDK5 HTRA2 25348397 N/A physical interaction ComPPI
DIABLO HTRA2 11604410 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HTRA2 BIRC2 11583623 11604410 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
HTRA2 BIRC3 11583623 14525934 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
HTRA2 BIRC7 11801603 14525934 24234451 25348397 physical association experimental interaction detection,fluorescence polarization spectroscopy,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
HTRA2 CSN1S1 10971580 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HTRA2 BIRC6 14525934 15200957 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HTRA2 PRKN 25348397 N/A physical interaction ComPPI
HTRA2 LATS1 16007220 17130845 22641346 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HTRA2 PINK1 25348397 N/A physical interaction ComPPI
HTRA2 MAPK11 25348397 N/A physical interaction ComPPI
HTRA2 CDK1 25348397 N/A physical interaction ComPPI
HTRA2 NADK2 25348397 N/A physical interaction ComPPI
HTRA2 TIMM9 25348397 N/A physical interaction ComPPI
HTRA2 HPDL 25348397 N/A physical interaction ComPPI
HTRA2 CAP1 25348397 N/A physical interaction ComPPI
HTRA2 NDUFV1 25348397 N/A physical interaction ComPPI
HTRA2 OPA1 25348397 N/A physical interaction ComPPI
HTRA2 ACTA1 25348397 N/A physical interaction ComPPI
HTRA2 TUBB6 25348397 N/A physical interaction ComPPI
HTRA2 ALDH1A2 25348397 N/A physical interaction ComPPI
HTRA2 HSD17B10 25348397 N/A physical interaction ComPPI
HTRA2 EEF1A1P5 25348397 N/A physical interaction ComPPI
HTRA2 CCAR2 25348397 N/A physical interaction ComPPI
HTRA2 PDXDC1 25348397 N/A physical interaction ComPPI
HTRA2 AREL1 25348397 N/A physical interaction ComPPI
HTRA2 CD40 25348397 N/A physical interaction ComPPI
HTRA2 GOT1 25348397 N/A physical interaction ComPPI
HTRA2 KHSRP 25348397 N/A physical interaction ComPPI
HTRA2 PDCD6IP 25348397 N/A physical interaction ComPPI
HTRA2 TIA1 25348397 N/A physical interaction ComPPI
HTRA2 NDUFS3 25348397 N/A physical interaction ComPPI
HTRA2 NTAQ1 25348397 N/A physical interaction ComPPI
HTRA2 RANBP10 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
HTRA2 MAEA 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
HTRA2 MKLN1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
HTRA2 WDR26 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
HTRA2 ARMC8 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HTRA2 RNPS1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HTRA2 TNFRSF14 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HTRA2 NDUFA13 17297443 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid ComPPI,IntAct,OmniPath
HTRA2 PSEN1 10971580 24234451 25348397 physical association two hybrid ComPPI,IntAct
HTRA2 AIFM1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HTRA2 NDUFAF5 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
HTRA2 PHYHIPL 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
ASS1 HTRA2 25348397 N/A physical interaction ComPPI
CSN2 HTRA2 10971580 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MUL1 HTRA2 25348397 N/A physical interaction ComPPI
MRPL4 HTRA2 25348397 N/A physical interaction ComPPI
HTRA2 APP 14525934 15036614 27898060 N/A experimental interaction detection HPRD,OmniPath
CDK5 HTRA2 21701498 27898060 stimulant N/A OmniPath
HTRA2 BIRC6 15200957 15300255 15507451 15781261 27898060 inhibition N/A OmniPath
BIRC6 HTRA2 15200957 15300255 15507451 15781261 27898060 inhibition N/A OmniPath
BID HTRA2 15153524 15475455 27898060 N/A N/A OmniPath
AKT1 HTRA2 17311912 27898060 inhibition N/A OmniPath
BAK1 HTRA2 12232790 14585074 27898060 stimulant N/A OmniPath
HTRA2 XIAP 11583623 11602612 11604410 11606597 11801603 11803371 12835328 12865429 15200957 15201285 15300255 15781261 17311912 17906618 24698088 27898060 inhibition N/A OmniPath
HTRA2 BIRC2 11583623 11604410 11606597 12865429 27898060 inhibition N/A OmniPath
BIRC2 HTRA2 11583623 11604410 11606597 12865429 27898060 N/A N/A OmniPath
HTRA2 BIRC3 11583623 11606597 12815069 12865429 27898060 inhibition N/A OmniPath
BIRC3 HTRA2 11583623 11606597 12815069 12865429 27898060 N/A N/A OmniPath
BAX HTRA2 12232790 14585074 27898060 stimulant N/A OmniPath
AKT2 HTRA2 17311912 27898060 inhibition N/A OmniPath
PINK1 HTRA2 17906618 27898060 stimulant N/A OmniPath
MAPK12 HTRA2 21701785 24662565 27898060 N/A N/A OmniPath
HTRA2 PEA15 15328349 27898060 inhibition N/A OmniPath

Visualization










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