Gene Information gene info

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GENE：PRKCQ

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKCQ
FullNmae protein kinase C theta
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9410
EnsembleID ENSG00000065675
Uniprot Q04759

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKCQ necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKCQ mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKCQ immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRKCQ GO:0001558,GO:0001772,GO:0004672,GO:0004674,GO:0004674,GO:0004697,GO:0004697,GO:0004698,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0006355,GO:0006468,GO:0006509,GO:0006954,GO:0007411,GO:0016235,GO:0018105,GO:0032212,GO:0032740,GO:0032743,GO:0032753,GO:0034451,GO:0035556,GO:0035556,GO:0035739,GO:0038095,GO:0046627,GO:0046872,GO:0050870,GO:0051092,GO:0051973,GO:0060326,GO:0070233,GO:0090330,GO:0106310,GO:1904355,GO:2000318,GO:2000563,GO:2000570

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKCQ hsa:5588 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa04140 Autophagy - animal - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa04659 Th17 cell differentiation - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa04931 Insulin resistance - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa05131 Shigellosis - Homo sapiens (human)
PRKCQ hsa:5588 path:hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PRKCQ CARD11 10652356 15125833 15214048 15520247 15536066 16356856 16606694 17544292 17548359 18784374 19201850 23077238 23109003 23433459 23474202 23886063 25960930 26192618 interaction type,chemical activation reaction N/A ACSN,SignaLink
MAP4K3 PRKCQ 21983831 26192618 interaction type N/A ACSN
PDPK1 PRKCQ 10652356 11687500 11747822 12670391 15214048 15536066 15802604 16606694 17544292 17548359 17680028 18784374 18802401 19109239 19122654 19201850 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
LCK PRKCQ 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
CD4 PRKCQ 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 26192618 3263576 8478617 8986721 9438848 9738502 9751747 interaction type N/A ACSN
LCP2 PRKCQ 12640133 19909365 20189481 21536650 22786724 23474202 23620508 24343663 24584089 26192618 9765283 interaction type N/A ACSN
FLNA PRKCQ 16849481 21277899 26192618 27242793 interaction type N/A ACSN
PRKCQ STK39 10652356 15214048 15536066 16606694 17544292 17548359 18784374 19201850 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
PRKCQ TEC 10652356 11687500 11747822 12670391 15214048 15536066 15802604 16606694 17544292 17548359 17680028 18784374 18802401 19109239 19122654 19201850 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
PRKCQ MAP3K7 10652356 15214048 15536066 16606694 17363905 17544292 17548359 18784374 19201850 20164171 23077238 23109003 23433459 23474202 23886063 25960930 26192618 interaction type,chemical activation reaction N/A ACSN,SignaLink
PRKCQ BAD 10652356 15214048 15536066 16606694 17544292 17548359 18784374 19201850 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
PRKCQ WIPF1 10652356 12811837 15214048 15536066 16606694 17544292 17548359 18784374 19201850 19833085 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
PRKCQ GZMB 10652356 12811837 15214048 15536066 16606694 17544292 17548359 18784374 19201850 19833085 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
PRKCQ GZMA 10652356 12811837 15214048 15536066 16606694 17544292 17548359 18784374 19201850 19833085 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
PRKCQ STAT1 10652356 12811837 15214048 15536066 16606694 17544292 17548359 18784374 19201850 19833085 23077238 23433459 23474202 23886063 25960930 26192618 interaction type N/A ACSN
IKBKB PRKCQ 11120819 23180781 physical association anti tag coimmunoprecipitation InnateDB
PRKCQ CHUK 11120819 23180781 physical association anti tag coimmunoprecipitation InnateDB
PRKCQ HABP4 14699138 23180781 phosphorylation reaction protein kinase assay InnateDB
PRKCQ PRKCZ 17588663 23180781 physical association two hybrid InnateDB
PRKCQ PRKCI 17588663 23180781 physical association anti tag coimmunoprecipitation InnateDB
PRKCQ SELL 15192100 23180781 physical association pull down InnateDB
VAV1 PRKCQ 10725744 11956228 15802604 23109003 23331499 stimulation,chemical activation reaction N/A SignaLink,SignaLink
AKT3 PRKCQ 11410591 23109003 chemical activation reaction N/A SignaLink
VAV3 PRKCQ 11956228 15802604 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
BCL10 PRKCQ 20005715 interaction type N/A PSP
CISH PRKCQ 20005715 interaction type N/A PSP
IRS1 PRKCQ 20005715 interaction type N/A PSP
YWHAG PRKCQ 20005715 interaction type N/A PSP
CISH PRKCQ 12618484 18988627 20005715 20005715 N/A N/A SignaLink
IRS1 PRKCQ 20005715 20005715 N/A N/A SignaLink
BCL10 PRKCQ 20005715 20005715 20164171 21071413 N/A N/A SignaLink
YWHAG PRKCQ 10433554 10433554 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 PRKCQ 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 PRKCQ 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PRKCQ 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PRKCQ 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PRKCQ 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PRKCQ 18971253 21252065 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PRKCQ 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
PRKCQ RDX 22135298 phosphorylation N/A PhosphoSite
PRKCQ BAD 22135298 phosphorylation N/A PhosphoSite
PRKCQ EZR 22135298 phosphorylation N/A PhosphoSite
PRKCQ PRKCQ 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCQ IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCQ PTPN7 22135298 phosphorylation N/A PhosphoSite
PRKCQ CCDC88A 22135298 phosphorylation N/A PhosphoSite
PRKCQ RASGRP1 22135298 phosphorylation N/A PhosphoSite
PRKCQ CARD11 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCQ NR2F6 22135298 phosphorylation N/A PhosphoSite
PRKCQ H3C1 22135298 phosphorylation N/A PhosphoSite
PRKCQ FOSL1 22135298 phosphorylation N/A PhosphoSite
PRKCQ MSN 22135298 phosphorylation N/A PhosphoSite
PRKCQ WIPF1 22135298 phosphorylation N/A PhosphoSite
PRKCQ RAPGEF2 22135298 phosphorylation N/A PhosphoSite
PRKCQ CBLB 22135298 phosphorylation N/A PhosphoSite
PRKCQ HABP4 22135298 phosphorylation N/A PhosphoSite
PRKCQ STK39 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCQ ICAM3 22135298 phosphorylation N/A PhosphoSite
PRKCQ PPP1R12A 22135298 phosphorylation N/A PhosphoSite
PRKCQ ARHGEF6 22135298 phosphorylation N/A PhosphoSite
PRKCQ RASGRP3 22135298 phosphorylation N/A PhosphoSite
LCK PRKCQ 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP4K3 PRKCQ 22135298 phosphorylation N/A PhosphoSite
PRKCQ BCL10 25361965 interaction type N/A PTMCode2
BCL10 PRKCQ 25361965 interaction type N/A PTMCode2
IRS1 PRKCQ 25361965 interaction type N/A PTMCode2
PRKCQ CASP3 25361965 interaction type N/A PTMCode2
CASP3 PRKCQ 25361965 interaction type N/A PTMCode2
PRKCQ MALT1 25361965 interaction type N/A PTMCode2
MALT1 PRKCQ 25361965 interaction type N/A PTMCode2
PRKCQ LCK 25361965 interaction type N/A PTMCode2
PRKCQ PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 PRKCQ 25361965 interaction type N/A PTMCode2
STK39 PRKCQ 25361965 interaction type N/A PTMCode2
PRKCQ IKBKG 25361965 interaction type N/A PTMCode2
IKBKG PRKCQ 25361965 interaction type N/A PTMCode2
PRKCQ CHUK 25361965 interaction type N/A PTMCode2
CHUK PRKCQ 25361965 interaction type N/A PTMCode2
CARD11 PRKCQ 25361965 interaction type N/A PTMCode2
PRKCQ MARK3 25361965 interaction type N/A PTMCode2
MARK3 PRKCQ 25361965 interaction type N/A PTMCode2
CARD10 PRKCQ 25361965 interaction type N/A PTMCode2
PRKCQ CARD10 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
LCP2 PRKCQ 21983831 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DEF6 PRKCQ 25348397 N/A physical interaction ComPPI
GLRX3 PRKCQ 10636891 14525934 24234451 25348397 colocalization,physical association two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
YWHAG PRKCQ 10433554 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSP90AB1 PRKCQ 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CBL PRKCQ 25348397 N/A physical interaction ComPPI
VAV1 PRKCQ 10725744 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BTK PRKCQ 11788586 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct
PRKCQ LYN 11358993 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCQ MSN 14525934 25348397 9516463 9856983 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCQ CASP3 14525934 25348397 9252332 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCQ WIPF1 12504004 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCQ CISH 12618484 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCQ MARK3 17363905 24234451 25348397 physical association anti bait coimmunoprecipitation,in vitro,in vivo ComPPI,IntAct
PRKCQ IKBKB 11120819 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKCQ STK39 10980603 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCQ HABP4 14525934 14699138 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCQ GRM5 25348397 N/A in vitro ComPPI
PRKCQ CARD11 14525934 14673152 22528498 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
PRKCQ CHUK 14525934 15802604 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKCQ RASGRP3 12730099 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PRKCQ IRS1 14525934 15364919 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCQ FYN 10383400 14525934 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,enzyme linked immunosorbent assay,protein kinase assay,in vitro,two hybrid ComPPI,HPRD,IntAct
PRKCQ ICAM3 14525934 25348397 9268366 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PRKCQ LCK 10652356 14525934 21964608 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRKCQ AKT1 11410591 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKCQ TAL1 25348397 N/A physical interaction ComPPI
PRKCQ PDPK1 25348397 N/A physical interaction ComPPI
PRKCQ IKBKG 14525934 15802604 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
PRKCQ JUND 25348397 N/A physical interaction ComPPI
PRKCQ NFE2L2 25348397 N/A physical interaction ComPPI
PRKCQ MAP3K7 25348397 N/A physical interaction ComPPI
PRKCQ FYB1 25348397 N/A physical interaction ComPPI
PRKCQ KCNA5 25348397 N/A physical interaction ComPPI
PRKCQ SELL 25348397 N/A physical interaction ComPPI
PRKCQ MALT1 17363905 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCQ HSP90AA1 25348397 N/A physical interaction ComPPI
PRKCQ HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKCQ PRKCD 23455922 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PRKCQ ALK 25348397 N/A physical interaction ComPPI
PRKCQ C2CD2L 25348397 N/A physical interaction ComPPI
PRKCQ ZNF24 25348397 N/A physical interaction ComPPI
PRKCQ PRKCZ 17588663 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,protein kinase assay ComPPI,IntAct
PRKCQ MEF2A 20178747 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
PRKCQ CD28 21964608 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PRKCQ MAP4K3 21983831 24234451 25348397 association,physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
PRKCQ HSF1 23352416 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,protein kinase assay ComPPI,IntAct
PKM PRKCQ 25348397 N/A protein kinase assay ComPPI
YWHAQ PRKCQ 25348397 N/A physical interaction ComPPI
BCL10 PRKCQ 17363905 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCQ PRKCQ 14525934 16252004 N/A experimental interaction detection HPRD
LCK PRKCQ 10652356 11772397 16460447 17548359 21964608 27898060 stimulant N/A OmniPath
FYN PRKCQ 10383400 27898060 stimulant N/A OmniPath
PRKCQ NOS3 24379783 27898060 inhibition N/A OmniPath
PRKCQ CHUK 11120819 15802604 17363905 20164171 27898060 stimulant N/A OmniPath
PRKCQ FOXO3 11154281 11980723 27898060 N/A N/A OmniPath
CDK2 PRKCQ 11772397 27898060 N/A N/A OmniPath
PRKCQ PPP1R12A 12563012 14709404 15226371 15665056 16038801 16130142 16219803 16421202 17085525 17110524 17158339 18648664 19470783 24610576 26215804 27898060 N/A N/A OmniPath
PDPK1 PRKCQ 15802604 27898060 stimulant N/A OmniPath
PRKCQ IRS1 15364919 27898060 stimulant N/A OmniPath
PRKCQ FOSL1 21822309 22286759 27898060 N/A N/A OmniPath
PRKCZ PRKCQ 17588663 27898060 N/A N/A OmniPath
PRKCQ HSF1 23352416 27898060 stimulant N/A OmniPath
PRKCQ CARD11 14673152 16356855 16356856 19118383 20164171 21157432 24548923 27898060 stimulant N/A OmniPath
PRKCQ IKBKB 11120819 15802604 17363905 20164171 27898060 stimulant N/A OmniPath
PRKCQ CBLB 19549985 27898060 N/A N/A OmniPath
PRKCQ PTPN7 16479000 27898060 N/A N/A OmniPath
PRKCQ CCDC88A 23509302 27898060 N/A N/A OmniPath
PRKCQ RASGRP3 12730099 15545601 15657177 27898060 stimulant N/A OmniPath
VAV1 PRKCQ 10725744 27898060 stimulant N/A OmniPath
PRKCQ ARHGEF6 25694429 27898060 N/A N/A OmniPath
PRKCQ RASGRP1 15899849 27898060 stimulant N/A OmniPath
PRKCQ MSN 10480873 15634677 16601072 19027715 21666723 21725352 25231728 27898060 9516463 9856983 stimulant N/A OmniPath
PRKCQ KRAS 16483930 18182391 18458061 25713064 27898060 N/A N/A OmniPath
PRKCQ STK39 10980603 14988727 27898060 stimulant N/A OmniPath
PRKCQ HABP4 14699138 27898060 inhibition N/A OmniPath
PRKCQ RAPGEF2 18796635 27898060 stimulant N/A OmniPath
MAP4K3 PRKCQ 11772397 16009340 16252004 21983831 27898060 stimulant N/A OmniPath
PRKCQ RDX 11146558 14504278 15676024 17447891 19255442 19395553 20801872 21864676 21979959 25531779 25799996 27898060 stimulant N/A OmniPath
PRKCQ ICAM3 11784723 27898060 9268366 stimulant N/A OmniPath
PRKCQ CIITA 11416140 27898060 N/A N/A OmniPath
PRKCQ WIPF1 12504004 17711847 24962707 27898060 stimulant N/A OmniPath

Visualization










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