Gene Information gene info

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GENE：IFNB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IFNB1
FullNmae interferon beta 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5434
EnsembleID ENSG00000171855
Uniprot P01574

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IFNB1 immunogenic 37275552 To identify genes associated with ICD, we collected 34 ICD-related genes from previously reported literature. retulator signature
IFNB1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IFNB1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IFNB1 GO:0002250,GO:0002286,GO:0002312,GO:0002323,GO:0005125,GO:0005125,GO:0005126,GO:0005126,GO:0005132,GO:0005132,GO:0005515,GO:0005576,GO:0005615,GO:0005615,GO:0006959,GO:0007166,GO:0007259,GO:0008811,GO:0009615,GO:0010508,GO:0019221,GO:0019221,GO:0030101,GO:0030183,GO:0033141,GO:0033141,GO:0035458,GO:0042100,GO:0042100,GO:0043330,GO:0043330,GO:0045071,GO:0045087,GO:0045089,GO:0045343,GO:0045581,GO:0045944,GO:0051607,GO:0051607,GO:0060337,GO:0060337,GO:0070050,GO:0071360,GO:0098586,GO:0098586,GO:0140123,GO:2000552,GO:2001235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IFNB1 hsa:3456 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04217 Necroptosis - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04380 Osteoclast differentiation - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04623 Cytosolic DNA-sensing pathway - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05131 Shigellosis - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05135 Yersinia infection - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05142 Chagas disease - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05152 Tuberculosis - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05160 Hepatitis C - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05161 Hepatitis B - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05162 Measles - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05164 Influenza A - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05167 Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IFNB1 hsa:3456 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IFNB1 PRDM1 15494505 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 IFNB1 11090630 12077266 15494505 1579446 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF2 IFNB1 11090630 15494505 1579446 23180781 9092512 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF8 IFNB1 23180781 9092512 physical association electrophoretic mobility supershift assay InnateDB
IFNB1 IRF3 10848607 15664995 15699120 16014923 16537619 16984921 17035306 17560375 17652396 18781139 19152337 19349300 20581830 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,x-ray crystallography,electrophoretic mobility supershift assay InnateDB
IFNB1 HMGA1 23180781 8934574 physical association electrophoretic mobility supershift assay InnateDB
IFNB1 RELA 10848607 11090630 15699120 16014923 16984921 22531926 23180781 9405619 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
NFKB1 IFNB1 10848607 11090630 12077266 15699120 16014923 17652396 23180781 9405619 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IRF7 IFNB1 10938111 14729983 15664995 16014923 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
EP300 IFNB1 15664995 19349300 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IFNB1 RELB 15699120 23180781 physical association affinity chromatography technology InnateDB
REL IFNB1 15699120 23180781 physical association affinity chromatography technology InnateDB
IFNB1 ATF2 10848607 11090630 17652396 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IFNB1 JUN 10848607 17652396 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IRF5 IFNB1 19129183 23180781 physical association affinity chromatography technology InnateDB
BRCA1 IFNB1 17374731 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNB1 STAT1 17374731 23180781 physical association anti tag coimmunoprecipitation InnateDB
CREBBP IFNB1 11090630 19218087 19349300 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IFNB1 TBP 11090630 23180781 physical association affinity chromatography technology InnateDB
IFNB1 GTF2B 11090630 23180781 physical association affinity chromatography technology InnateDB
IFNB1 MAFB 20581830 23180781 physical association anti tag coimmunoprecipitation InnateDB
IFNB1 POLR2F 23180781 23994473 physical association anti tag coimmunoprecipitation InnateDB
ELF4 IFNB1 23180781 24185615 physical association anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
IFNB1 IFNAR1 1834641 18988627 23331499 8181059 stimulation N/A SignaLink,SignaLink
IFNB1 IFNAR2 23331499 8181059 stimulation N/A SignaLink,SignaLink
IFNB1 TYK2 10542297 23331499 stimulation N/A SignaLink,SignaLink
IFNB1 JAK1 10918594 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
HMGA2 IFNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 IFNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IFNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IFNB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 IFNB1 10848607 17496231 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 IFNB1 17073600 18575764 22547704 8021262 trascriptional regulation,stimulation inferred by curator TFlink
IRF2 IFNB1 17073600 8021262 trascriptional regulation,stimulation inferred by curator TFlink
IRF3 IFNB1 10848607 12077266 15955070 16125763 17079305 17496231 19541850 20048166 20453844 20483755 23096996 trascriptional regulation,stimulation inferred by curator TFlink
IRF7 IFNB1 17236232 22547704 22698399 23906644 trascriptional regulation,stimulation inferred by curator TFlink
JUN IFNB1 10848607 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IFNB1 10074115 12077266 15955070 16125763 17079305 17496231 trascriptional regulation,stimulation inferred by curator TFlink
NFKBIA IFNB1 10074115 trascriptional regulation,stimulation inferred by curator TFlink
NFKBIB IFNB1 10074115 trascriptional regulation,stimulation inferred by curator TFlink
PML IFNB1 11042692 trascriptional regulation,stimulation inferred by curator TFlink
RELA IFNB1 10074115 12077266 15955070 16125763 17079305 17496231 22547704 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 IFNB1 19096445 trascriptional regulation,stimulation inferred by curator TFlink
YY1 IFNB1 22065573 trascriptional regulation,stimulation inferred by curator TFlink
PGR IFNB1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000324096 IFNB1 20130213 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 IFNB1 20130213 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 IFNB1 20130213 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000324096 IFNB1 20130213 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F4657 IFNB1 20130213 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 IFNB1 20130213 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001A4ABF IFNB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 IFNB1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 IFNB1 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IFNAR1 IFNB1 25361965 interaction type N/A PTMCode2
IFNB1 IFNAR1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PEX19 IFNB1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IFNAR1 IFNB1 14525934 1834641 25348397 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,biochemical,in vivo ComPPI,HPRD
IFNB1 IFNAR2 10395669 14525934 25348397 N/A experimental interaction detection,physical interaction,biochemical ComPPI,HPRD
IFNB1 IFNB1 14525934 9342320 N/A experimental interaction detection HPRD
IFNB1 IFNAR1 10049744 11278538 1834641 27898060 7592797 7623815 8181059 stimulant N/A OmniPath
IFNB1 JAK1 10918594 27898060 stimulant N/A OmniPath
IFNB1 TYK2 10542297 27898060 stimulant N/A OmniPath
IRF3 IFNB1 16410796 27898060 stimulant N/A OmniPath
IRF7 IFNB1 16410796 27898060 stimulant N/A OmniPath
IL24 IFNB1 18511292 27898060 stimulant N/A OmniPath
IFNB1 IFNAR2 10395669 11278538 27898060 7623815 8181059 stimulant N/A OmniPath

Visualization










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