Gene Information gene info

  1. Home

GENE：IL12A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL12A
FullNmae interleukin 12A
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5969
EnsembleID ENSG00000168811
Uniprot P29459

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL12A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL12A apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IL12A GO:0001916,GO:0002860,GO:0005125,GO:0005125,GO:0005143,GO:0005515,GO:0005515,GO:0005576,GO:0005615,GO:0005788,GO:0006955,GO:0008083,GO:0008083,GO:0009615,GO:0010224,GO:0016477,GO:0031906,GO:0032496,GO:0032700,GO:0032729,GO:0032816,GO:0032946,GO:0034393,GO:0035722,GO:0042163,GO:0042531,GO:0043514,GO:0043514,GO:0045513,GO:0045785,GO:0045954,GO:0046982,GO:0048662,GO:0050671,GO:0050709,GO:0050830,GO:0051135,GO:0097191,GO:0098586,GO:1900747,GO:1903588,GO:2000510

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL12A hsa:3592 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL12A hsa:3592 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
IL12A hsa:3592 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
IL12A hsa:3592 path:hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
IL12A hsa:3592 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL12A hsa:3592 path:hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
IL12A hsa:3592 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
IL12A hsa:3592 path:hsa04940 Type I diabetes mellitus - Homo sapiens (human)
IL12A hsa:3592 path:hsa05133 Pertussis - Homo sapiens (human)
IL12A hsa:3592 path:hsa05134 Legionellosis - Homo sapiens (human)
IL12A hsa:3592 path:hsa05140 Leishmaniasis - Homo sapiens (human)
IL12A hsa:3592 path:hsa05142 Chagas disease - Homo sapiens (human)
IL12A hsa:3592 path:hsa05143 African trypanosomiasis - Homo sapiens (human)
IL12A hsa:3592 path:hsa05144 Malaria - Homo sapiens (human)
IL12A hsa:3592 path:hsa05145 Toxoplasmosis - Homo sapiens (human)
IL12A hsa:3592 path:hsa05146 Amoebiasis - Homo sapiens (human)
IL12A hsa:3592 path:hsa05152 Tuberculosis - Homo sapiens (human)
IL12A hsa:3592 path:hsa05162 Measles - Homo sapiens (human)
IL12A hsa:3592 path:hsa05164 Influenza A - Homo sapiens (human)
IL12A hsa:3592 path:hsa05168 Herpes simplex virus 1 infection - Homo sapiens (human)
IL12A hsa:3592 path:hsa05171 Coronavirus disease - COVID-19 - Homo sapiens (human)
IL12A hsa:3592 path:hsa05200 Pathways in cancer - Homo sapiens (human)
IL12A hsa:3592 path:hsa05321 Inflammatory bowel disease - Homo sapiens (human)
IL12A hsa:3592 path:hsa05330 Allograft rejection - Homo sapiens (human)
IL12A hsa:3592 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IRF3 IL12A 16219795 19164128 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
REL IL12A 12820969 19122653 20876114 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRF1 IL12A 14568984 15489234 18316378 19164128 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IRF8 IL12A 15489234 18316378 19164128 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IL12A STAT1 19164128 23180781 physical association affinity chromatography technology InnateDB
STAT2 IL12A 19164128 23180781 physical association affinity chromatography technology InnateDB
IRF4 IL12A 19164128 23180781 physical association affinity chromatography technology InnateDB
IRF7 IL12A 19164128 23180781 physical association affinity chromatography technology InnateDB
IRF5 IL12A 19164128 21240265 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
IL12A IRF9 19164128 23180781 physical association affinity chromatography technology InnateDB
RELA IL12A 19122653 19164128 20876114 23180781 physical association affinity chromatography technology,anti tag coimmunoprecipitation InnateDB
NFKB1 IL12A 19164128 23180781 physical association affinity chromatography technology InnateDB
SP1 IL12A 12576336 23180781 physical association electrophoretic mobility supershift assay InnateDB
IL12B IL12A 10899108 23180781 7527811 8943050 disulfide bond,physical association x-ray crystallography,comigration in non denaturing gel electrophoresis,competition binding InnateDB
EBI3 IL12A 23180781 9342359 physical association anti tag coimmunoprecipitation InnateDB
IL12RB1 IL12A 23180781 7911493 8943050 physical association competition binding InnateDB
IL12A IL12RB1 23331499 7527811 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
AR IL12A 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 IL12A 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL12A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
IRF1 IL12A 16622221 trascriptional regulation,stimulation inferred by curator TFlink
IRF8 IL12A 16622221 trascriptional regulation,stimulation inferred by curator TFlink
JUN IL12A 22904313 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 IL12A 18690006 trascriptional regulation,stimulation inferred by curator TFlink
RELA IL12A 18690006 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 IL12A 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS000009262D IL12A 22815788 25327529 25416803 27571873 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000016D2D4 IL12A 25281418 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CD28 IL12A 14525934 25348397 27898060 7516408 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
RAB3B IL12A 25348397 N/A physical interaction ComPPI
WASF1 IL12A 14525934 16862120 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
F11R IL12A 25348397 N/A physical interaction ComPPI
IL12RB1 IL12A 11114383 24234451 25348397 physical association cross-linking study,fluorescence-activated cell sorting,physical interaction ComPPI,IntAct
IL12RB2 IL12A 25348397 N/A cross-linking study,physical interaction ComPPI
CXCL8 IL12A 14525934 16862120 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
EBI3 IL12A 14525934 18033300 24234451 25348397 27898060 934235 9342359 physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct,OmniPath
IL12A SPDL1 25348397 N/A physical interaction ComPPI
IL12A FSTL1 25348397 N/A physical interaction ComPPI
IL12A COL14A1 25348397 N/A physical interaction ComPPI
IL12B IL12A 10899108 14525934 24234451 25348397 7527811 physical association coimmunoprecipitation,experimental interaction detection,x-ray crystallography,physical interaction,comigration in non denaturing gel electrophoresis,in vitro ComPPI,HPRD,IntAct
IL12A IL12A 14525934 7527811 N/A experimental interaction detection HPRD
IL12A IL12RB1 11086056 12023369 27898060 7911493 8943050 stimulant N/A OmniPath
IL12A IL12B 10779781 10899108 27898060 7527811 8943050 stimulant N/A OmniPath
IL12A IL12RB2 11086056 27898060 8943050 943050 stimulant N/A OmniPath

Visualization










  Return