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GENE：MAP3K8

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K8
FullNmae mitogen-activated protein kinase kinase kinase 8
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6860
EnsembleID ENSG00000107968
Uniprot P41279

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K8 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K8 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K8 GO:0000165,GO:0000287,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005829,GO:0005829,GO:0006468,GO:0007049,GO:0031295,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K8 hsa:1326 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP3K8 hsa:1326 path:hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human)
MAP3K8 hsa:1326 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
MAP3K8 hsa:1326 path:hsa04668 TNF signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IKBKG MAP3K8 11280761 11438547 11460167 12133805 12811837 14660645 15145317 15199157 15485931 15536066 15573129 16818229 16970925 17237376 17254973 17301840 17363905 17485448 17693255 18264787 18716620 19833085 20138012 20300203 21133840 21217011 21232017 21807870 22435554 23086447 23422957 23430059 24378531 24699077 24766893 24958845 26192618 2649237 28462531 interaction type N/A ACSN
KSR2 MAP3K8 12975377 23180781 physical association anti tag coimmunoprecipitation InnateDB
NFKB1 MAP3K8 15169888 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNIP2 MAP3K8 15169888 19754427 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
MAP3K8 CHUK 10072079 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K14 MAP3K8 10072079 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K8 MAP3K8 19754427 23180781 phosphorylation reaction protein kinase assay InnateDB
EGR1 MAP3K8 19374776 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K8 MAP2K1 23331499 8631303 stimulation N/A SignaLink,SignaLink
MAP3K8 MAP2K4 23331499 8631303 stimulation N/A SignaLink
MAP3K8 MAP2K5 10669751 23331499 stimulation N/A SignaLink
AKT3 MAP3K8 12138205 23109003 chemical activation reaction N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SPTBN1 MAP3K8 20005715 interaction type N/A PSP,SignaLink
TNIP2 MAP3K8 20005715 interaction type N/A PSP
TRAF2 MAP3K8 20005715 interaction type N/A PSP
TNIP2 MAP3K8 14743216 15169888 18988627 20005715 20005715 21071413 N/A N/A SignaLink
TRAF2 MAP3K8 11932422 11932422 16291755 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP3K8 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 MAP3K8 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MAP3K8 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MAP3K8 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP3K8 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 MAP3K8 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 MAP3K8 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MAP3K8 18971253 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 MAP3K8 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004900F1 MAP3K8 17621267 \N rna interference,inhibition experimental interaction detection,western blot,miRNA interference luciferase reporter assay miRSponge
URS00000ED600 MAP3K8 23430746 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004900F1 MAP3K8 17621267 18927107 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00000ED600 MAP3K8 23430746 25416803 28186962 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00001EFEC1 MAP3K8 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000237AF9 MAP3K8 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA MAP3K8 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002E92A8 MAP3K8 25416803 27717821 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004214BB MAP3K8 25416803 27835990 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K8 RDX 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MAP2K3 22135298 phosphorylation N/A PhosphoSite
MAP3K8 EZR 22135298 phosphorylation N/A PhosphoSite
MAP3K8 ABL1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 CREB1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 EIF4G1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MAP2K6 22135298 phosphorylation N/A PhosphoSite
MAP3K8 EIF4EBP1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 PLK1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MAP2K1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP3K8 RPS6KA1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MSN 22135298 phosphorylation N/A PhosphoSite
MAP3K8 CDK1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 MAP2K2 22135298 phosphorylation N/A PhosphoSite
MAP3K8 H2BC3 22135298 phosphorylation N/A PhosphoSite
MAP3K8 CHEK1 22135298 phosphorylation N/A PhosphoSite
MAP3K8 NPM1 22135298 phosphorylation N/A PhosphoSite
AKT1 MAP3K8 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP3K8 AKT1 25361965 interaction type N/A PTMCode2
MAP3K8 REL 25361965 interaction type N/A PTMCode2
REL MAP3K8 25361965 interaction type N/A PTMCode2
MAP2K1 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 TNIP2 25361965 interaction type N/A PTMCode2
TNIP2 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 KSR2 25361965 interaction type N/A PTMCode2
KSR2 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 CHUK 25361965 interaction type N/A PTMCode2
CHUK MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 CD40 25361965 interaction type N/A PTMCode2
CD40 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 RELA 25361965 interaction type N/A PTMCode2
RELA MAP3K8 25361965 interaction type N/A PTMCode2
RIPK1 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 RIPK1 25361965 interaction type N/A PTMCode2
NFKB1 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 NFKB1 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K8 25361965 interaction type N/A PTMCode2
MAP3K8 MAP2K4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PIN1 MAP3K8 24234451 24265246 25348397 27898060 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,protein kinase assay ComPPI,IntAct,OmniPath
HSPA8 MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ACY3 MAP3K8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TUBB MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
TRAF6 MAP3K8 14525934 15670770 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CALM1 MAP3K8 25348397 N/A tandem affinity purification ComPPI
HSP90AB1 MAP3K8 14743216 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,tandem affinity purification,luminescence based mammalian interactome mapping ComPPI,IntAct
REL MAP3K8 14525934 14743216 24234451 25348397 9950430 physical association experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
PFKL MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
HSP90AA1 MAP3K8 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
RUVBL1 MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP2K4 MAP3K8 14525934 25348397 8631303 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
STIP1 MAP3K8 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSPA5 MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP2K1 MAP3K8 12832462 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
KSR2 MAP3K8 25348397 N/A physical interaction ComPPI
BMPR2 MAP3K8 14525934 15188402 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RELA MAP3K8 14525934 14743216 24234451 25348397 25852190 9950430 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
XPO1 MAP3K8 25348397 N/A physical interaction ComPPI
TRAF2 MAP3K8 11932422 14525934 16291755 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CLTC MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
SPTBN1 MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ACTL6A MAP3K8 25348397 N/A tandem affinity purification ComPPI
CHUK MAP3K8 10072079 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TNIP2 MAP3K8 14525934 14743216 15169888 24234451 25348397 25852190 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,tandem affinity purification ComPPI,HPRD,IntAct
HSPA9 MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
RIPK1 MAP3K8 14525934 16291755 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP3K8 CD40 14525934 15670770 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP3K8 NFKB1 12832462 14525934 14743216 16291755 21988832 24234451 25348397 25609649 25852190 9950430 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,isothermal titration calorimetry,pull down,surface plasmon resonance,physical interaction,in vitro,in vivo,enzymatic footprinting,tandem affinity purification,two hybrid ComPPI,HPRD,IntAct
MAP3K8 NFKB2 14525934 14743216 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
MAP3K8 AKT1 12138205 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAP3K8 TAB2 25348397 N/A physical interaction ComPPI
MAP3K8 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP3K8 HSPA1L 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K8 EPPK1 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K8 LGALS3BP 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K8 TUBB4A 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K8 DSP 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K8 TUBA3C 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K14 MAP3K8 10072079 11278268 14525934 25348397 9742107 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EEF1A2 MAP3K8 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
MAP3K8 MAP3K8 14743216 24234451 physical association tandem affinity purification IntAct
CALM2 MAP3K8 14743216 24234451 physical association tandem affinity purification IntAct
MAP3K8 CAV1 14992595 27898060 N/A N/A OmniPath
MAP3K8 PLK1 12207013 27898060 stimulant N/A OmniPath
MAPKAPK2 MAP3K8 12138205 15466476 27898060 N/A N/A OmniPath
CHUK MAP3K8 10072079 27898060 N/A N/A OmniPath
MAP3K8 CHUK 10072079 27898060 stimulant N/A OmniPath
MAP3K8 MAP2K1 12832462 15466476 16291755 17906627 18187448 27898060 8131746 8631303 9351825 stimulant N/A OmniPath
MAP3K8 MAP3K14 10072079 11278268 18439422 27898060 9742107 stimulant N/A OmniPath
MAP3K14 MAP3K8 10072079 11278268 27898060 9742107 N/A N/A OmniPath
MAP3K8 RPS6KA1 12134064 15647351 20385620 21183680 25855080 27898060 N/A N/A OmniPath
MAP3K8 KSR2 12975377 27898060 N/A N/A OmniPath
KSR2 MAP3K8 12975377 27898060 inhibition N/A OmniPath
MAP3K8 MAP2K2 12506122 12609978 15466476 17101779 17906627 18187448 27898060 stimulant N/A OmniPath
MAP3K8 RANGAP1 15037602 27898060 N/A N/A OmniPath
NFKB1 MAP3K8 12832462 14743216 15169888 16291755 18270204 21988832 22435554 25852190 27898060 9950430 inhibition N/A OmniPath
MAP3K8 NFKB1 12832462 14743216 15169888 16291755 18270204 21988832 25852190 27898060 9950430 inhibition N/A OmniPath
AKT1 MAP3K8 12138205 27898060 inhibition,stimulant N/A OmniPath
TLR4 MAP3K8 16484370 27898060 N/A N/A OmniPath
MAP3K8 MAP2K4 15833743 22435554 27898060 8631303 stimulant N/A OmniPath
MAP3K8 MAP2K3 17637696 27898060 stimulant N/A OmniPath
MAP3K8 ABL1 15696159 16888623 18794806 19643477 27898060 N/A N/A OmniPath
MAP3K8 EZR 10893267 10970850 14993232 15843435 16144865 17553936 18725408 21818323 24379416 24413175 26042733 27898060 N/A N/A OmniPath
MAP3K8 CDK1 14988404 17554681 1833185 27898060 N/A N/A OmniPath
MAP3K8 EIF4G1 10654941 27898060 N/A N/A OmniPath
MAP3K8 MAP2K5 10669751 27898060 stimulant N/A OmniPath
MAP3K8 TNIP2 14743216 15169888 19754427 25852190 27898060 N/A N/A OmniPath
MAP3K8 H2BC3 10617636 27898060 N/A N/A OmniPath

Visualization










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