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GENE：IL7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IL7
FullNmae interleukin 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6023
EnsembleID ENSG00000104432
Uniprot P13232

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IL7 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IL7 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
IL7 GO:0001961,GO:0002360,GO:0005125,GO:0005139,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0006959,GO:0007267,GO:0008083,GO:0008284,GO:0009887,GO:0019221,GO:0030890,GO:0032722,GO:0035265,GO:0042100,GO:0043066,GO:0045453,GO:0045579,GO:0045582,GO:0046622,GO:0048873,GO:0050730,GO:0062023,GO:0097191,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IL7 hsa:3574 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
IL7 hsa:3574 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IL7 hsa:3574 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
IL7 hsa:3574 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
IL7 hsa:3574 path:hsa05200 Pathways in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IL7 IRF1 15226432 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL7 IRF2 15226432 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
IL7R IL7 23180781 8266077 physical association protein cross-linking with a bifunctional reagent InnateDB
IL2RG IL7 23180781 8266077 physical association anti tag coimmunoprecipitation InnateDB
IL7 JAK1 2317865 24243840 29145629 physical association inferred by curator Reactome
IL7 IRS2 29145629 9233603 9233603 physical association inferred by curator Reactome
IL7 IRS1 29145629 9233603 9233603 physical association inferred by curator Reactome
IL7 STAT5B 19864382 29145629 7489741 7719938 8709637 9715265 physical association inferred by curator Reactome
IL7 STAT5A 19864382 29145629 7489741 7719938 8709637 9715265 physical association inferred by curator Reactome
IL7 IL7R 23331499 8204885 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
YBX1 IL7 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 IL7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IL7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IL7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IL7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IL7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 IL7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 IL7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 IL7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB IL7 11675351 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 IL7 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 IL7 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 IL7 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00004DA9DB IL7 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD231 IL7 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000086A4D IL7 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 IL7 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 IL7 25416803 25962782 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CEBPE IL7 25348397 N/A physical interaction ComPPI
IL2RG IL7 11858939 14525934 24234451 25348397 8266077 9010926 physical association anti bait coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD,IntAct
IL7R IL7 10390077 11858939 14525934 19141282 24234451 25348397 8266077 physical association affinity chromatography technology,anti bait coimmunoprecipitation,cross-linking study,experimental interaction detection,surface plasmon resonance,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
IL7 APP 25348397 N/A physical interaction ComPPI
IL7 IL7R 10390077 11858939 1558969 19141282 20089933 27898060 7522165 8128231 8204885 8266077 8409434 stimulant N/A OmniPath
IL7 IL2RG 11418623 11858939 20089933 27898060 7522165 8128231 8266077 9010926 9371812 stimulant N/A OmniPath

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