GENE：ING2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ING2 |
| FullNmae | inhibitor of growth family member 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6063 |
| EnsembleID | ENSG00000168556 |
| Uniprot | Q9H160 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ING2 | parthanatos | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ING2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ING2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ING2 | GO:0000122,GO:0003677,GO:0003682,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005886,GO:0006355,GO:0006974,GO:0007141,GO:0007165,GO:0007283,GO:0007286,GO:0016580,GO:0016580,GO:0016602,GO:0030317,GO:0030336,GO:0030511,GO:0030512,GO:0035033,GO:0035064,GO:0035064,GO:0035091,GO:0044877,GO:0045814,GO:0045893,GO:0045893,GO:0046872,GO:0048133,GO:0072520,GO:0140566,GO:1902166,GO:1902455,GO:1902459,GO:2000772 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F4 | ING2 | 17531812 18971253 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| ETS1 | ING2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | ING2 | 18971253 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| SMARCA4 | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | ING2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ING2 | RBBP4 | 25361965 | interaction type | N/A | PTMCode2 |
| RBBP4 | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | PCNA | 25361965 | interaction type | N/A | PTMCode2 |
| PCNA | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | KAT5 | 25361965 | interaction type | N/A | PTMCode2 |
| KAT5 | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | TRRAP | 25361965 | interaction type | N/A | PTMCode2 |
| TRRAP | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | MRGBP | 25361965 | interaction type | N/A | PTMCode2 |
| MRGBP | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | ACTL6A | 25361965 | interaction type | N/A | PTMCode2 |
| ACTL6A | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| BRD8 | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | BRD8 | 25361965 | interaction type | N/A | PTMCode2 |
| SAP30 | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | SAP30 | 25361965 | interaction type | N/A | PTMCode2 |
| TP53 | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | TP53 | 25361965 | interaction type | N/A | PTMCode2 |
| DMAP1 | ING2 | 25361965 | interaction type | N/A | PTMCode2 |
| ING2 | DMAP1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PCNA | ING2 | 19730436 24234451 25348397 27898060 | physical association | anti bait coimmunoprecipitation,pull down,physical interaction | ComPPI,IntAct,OmniPath |
| SKIL | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| SMARCC1 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| BRMS1 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| CENPH | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| H4C1 | ING2 | 14525934 16782091 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SMURF2 | ING2 | 14525934 15761153 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SMAD1 | ING2 | 14525934 15761153 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| SMAD2 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| SUMO1 | ING2 | 20676127 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| EP300 | ING2 | 14525934 16024799 16782091 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD,IntAct |
| UBC | ING2 | 20621832 24234451 25348397 | physical association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| SIN3A | ING2 | 20676127 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| PRMT5 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| AHNAK | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| SMARCB1 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| RBBP4 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| COPS2 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| H3-4 | ING2 | 20953165 22595675 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| HDAC2 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| ACTL6A | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| SIRT1 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| SAP30 | ING2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| SIN3B | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| H3-3A | ING2 | 16728977 20953165 24234451 25348397 27898060 | physical association | pull down | ComPPI,IntAct,OmniPath |
| SMURF1 | ING2 | 14525934 15761153 20621832 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| SUDS3 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| BRMS1L | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| SMARCC2 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| ARID4B | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| SAP130 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| BAHCC1 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | HDAC1 | 23752268 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ING2 | RBBP7 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | ARID4A | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | TP53 | 25348397 | N/A | anti bait coimmunoprecipitation,physical interaction | ComPPI |
| ING2 | APP | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | AP5Z1 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | FOXK1 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| ING2 | FOXK2 | 24234451 25348397 25609649 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| ING2 | NANOGP8 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | NANOG | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | GATAD1 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | SINHCAF | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | SAP30L | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | TARS3 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | ZNF704 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | MXD3 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | PCM1 | 25348397 | N/A | physical interaction | ComPPI |
| WDR5 | ING2 | 25348397 | N/A | physical interaction | ComPPI |
| ING2 | EP300 | 16024799 16782091 27898060 | stimulant | N/A | OmniPath |