GENE：ITGA6
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | ITGA6 |
| FullNmae | integrin subunit alpha 6 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6142 |
| EnsembleID | ENSG00000091409 |
| Uniprot | P23229 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| ITGA6 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ITGA6 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| ITGA6 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| ITGA6 | GO:0005178,GO:0005515,GO:0005886,GO:0005886,GO:0005912,GO:0005925,GO:0007044,GO:0007160,GO:0007229,GO:0008305,GO:0009897,GO:0009986,GO:0009986,GO:0010668,GO:0010811,GO:0010976,GO:0030175,GO:0030335,GO:0031589,GO:0031994,GO:0033627,GO:0034676,GO:0035878,GO:0038132,GO:0042327,GO:0043065,GO:0043236,GO:0043547,GO:0043589,GO:0045296,GO:0045944,GO:0046872,GO:0050900,GO:0071407,GO:0098609,GO:2001237 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| ITGA6 | hsa:3655 | path:hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa04514 | Cell adhesion molecules - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa05412 | Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human) |
| ITGA6 | hsa:3655 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ITGB1 | ITGA6 | 26192618 | association | N/A | ACSN |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | ITGA6 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | ITGA6 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | ITGA6 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | ITGA6 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | ITGA6 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | ITGA6 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | ITGA6 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PRDM14 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | ITGA6 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU5F1 | ITGA6 | 22311737 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SOX2 | ITGA6 | 22311737 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| JUN | ITGA6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | ITGA6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PGR | ITGA6 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000EED18 | ITGA6 | 21566225 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00002FC5B0 | ITGA6 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000065D58 | ITGA6 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS000041CB9C | ITGA6 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001A7F58 | ITGA6 | 25416803 28036265 | mrna cleavage,inhibition | western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000272A3D | ITGA6 | 24091622 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000076995 | ITGA6 | 24091622 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000821E0 | ITGA6 | 25416803 27502506 | mrna cleavage,inhibition | array technology,nucleotide sequence identification,western blot,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GIPC1 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | GIPC1 | 25361965 | interaction type | N/A | PTMCode2 |
| CD82 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | CD82 | 25361965 | interaction type | N/A | PTMCode2 |
| CD63 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | CD63 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB2 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | ITGB2 | 25361965 | interaction type | N/A | PTMCode2 |
| CD151 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | CD151 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB4 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | ITGB4 | 25361965 | interaction type | N/A | PTMCode2 |
| MACF1 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | MACF1 | 25361965 | interaction type | N/A | PTMCode2 |
| TSPAN4 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | TSPAN4 | 25361965 | interaction type | N/A | PTMCode2 |
| GRB2 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| COL17A1 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | COL17A1 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB1 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | ITGB1 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGB7 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | ITGB7 | 25361965 | interaction type | N/A | PTMCode2 |
| CD36 | ITGA6 | 25361965 | interaction type | N/A | PTMCode2 |
| ITGA6 | CD36 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RABIF | ITGA6 | 25348397 | N/A | physical interaction | ComPPI |
| CALM1 | ITGA6 | 25348397 | N/A | physical interaction | ComPPI |
| CD82 | ITGA6 | 14525934 25348397 8757325 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PICK1 | ITGA6 | 25348397 | N/A | physical interaction | ComPPI |
| CD36 | ITGA6 | 11238109 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| CD81 | ITGA6 | 24234451 25348397 30024968 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| CD9 | ITGA6 | 23289620 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| PRKCD | ITGA6 | 11389095 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| GRB2 | ITGA6 | 14525934 25348397 27898060 7556090 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| CD151 | ITGA6 | 10811835 14525934 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,experimental interaction detection,in vivo,confocal microscopy | ComPPI,HPRD,IntAct |
| ITGB1 | ITGA6 | 24234451 25348397 2649503 | physical association | physical interaction,in vivo,immunodepleted coimmunoprecipitation | ComPPI,IntAct |
| PDIA3 | ITGA6 | 17170699 24234451 25348397 | disulfide bond | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| CANX | ITGA6 | 14525934 25348397 8163531 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CDH1 | ITGA6 | 25348397 | N/A | physical interaction | ComPPI |
| PXN | ITGA6 | 25348397 | N/A | in vivo | ComPPI |
| PLEC | ITGA6 | 10525545 12791251 14525934 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,two hybrid | ComPPI,HPRD,OmniPath |
| ADAM9 | ITGA6 | 14525934 15361064 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| GIPC1 | ITGA6 | 11479315 11852236 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
| PCSK5 | ITGA6 | 10657249 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| BIN1 | ITGA6 | 10094488 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
| ITGA6 | COL17A1 | 11739652 14525934 25348397 9500991 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| ITGA6 | ITGB4 | 14525934 21880726 24234451 25348397 2649503 9660880 | colocalization,physical association | cross-linking study,experimental interaction detection,in vivo,confocal microscopy | ComPPI,HPRD,IntAct |
| ITGA6 | RPSA | 10477615 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ITGA6 | CD63 | 14525934 25348397 27898060 7629079 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| ITGA6 | APP | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | MOV10 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | NXF1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | LGALS8 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | MCOLN3 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | HLA-C | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | B4GALT4 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | HLA-E | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | BTNL8 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | CANT1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | PTCH1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | PON2 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | LGALS3BP | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | TMEM17 | 24234451 25348397 26638075 | association | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
| ITGA6 | CTDSPL | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | TSPAN11 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | PCDHGA5 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | TMPRSS11B | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | TMED6 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | HLA-DRB1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | GML | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | PCDHB16 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | PCDH20 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA6 | LAMP1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| TSPAN4 | ITGA6 | 14525934 25348397 9360996 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| ITGA6 | CCDC7 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| ITGA6 | SF3B2 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| PRKCD | ITGA6 | 11389095 12919677 27898060 | stimulant | N/A | OmniPath |
| ITGA6 | ITGB4 | 10842354 11438664 12867433 21880726 2649503 27898060 9660880 | N/A | N/A | OmniPath |
| ITGB1 | ITGA6 | 10842354 12883474 2649503 27898060 9425259 9660880 | N/A | N/A | OmniPath |
| THBS1 | ITGA6 | 12909644 27898060 | stimulant | N/A | OmniPath |
| GIPC1 | ITGA6 | 11479315 11852236 27898060 | N/A | N/A | OmniPath |
| LAMB1 | ITGA6 | 10842354 27898060 | stimulant | N/A | OmniPath |
| THBS2 | ITGA6 | 12909644 27898060 | stimulant | N/A | OmniPath |
| LAMA1 | ITGA6 | 10842354 27898060 | N/A | N/A | OmniPath |
| DUSP18 | ITGA6 | 10842354 27898060 | stimulant | N/A | OmniPath |