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GENE：ITGAM

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITGAM
FullNmae integrin subunit alpha M
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6149
EnsembleID ENSG00000169896
Uniprot P11215

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITGAM apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITGAM apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ITGAM GO:0001540,GO:0001774,GO:0001851,GO:0005178,GO:0005178,GO:0005515,GO:0005615,GO:0005886,GO:0005886,GO:0006898,GO:0006911,GO:0007155,GO:0007160,GO:0007229,GO:0008305,GO:0009897,GO:0009897,GO:0009986,GO:0009986,GO:0010668,GO:0030900,GO:0031072,GO:0032930,GO:0032930,GO:0033627,GO:0034688,GO:0035579,GO:0038024,GO:0043315,GO:0044853,GO:0045087,GO:0045963,GO:0046872,GO:0070062,GO:0070821,GO:0090314,GO:0097242,GO:0098609,GO:0098742,GO:0150062,GO:0150064,GO:1904151,GO:2000363

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITGAM hsa:3684 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
ITGAM hsa:3684 path:hsa04145 Phagosome - Homo sapiens (human)
ITGAM hsa:3684 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
ITGAM hsa:3684 path:hsa04610 Complement and coagulation cascades - Homo sapiens (human)
ITGAM hsa:3684 path:hsa04613 Neutrophil extracellular trap formation - Homo sapiens (human)
ITGAM hsa:3684 path:hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
ITGAM hsa:3684 path:hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
ITGAM hsa:3684 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ITGAM hsa:3684 path:hsa05133 Pertussis - Homo sapiens (human)
ITGAM hsa:3684 path:hsa05134 Legionellosis - Homo sapiens (human)
ITGAM hsa:3684 path:hsa05140 Leishmaniasis - Homo sapiens (human)
ITGAM hsa:3684 path:hsa05146 Amoebiasis - Homo sapiens (human)
ITGAM hsa:3684 path:hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
ITGAM hsa:3684 path:hsa05152 Tuberculosis - Homo sapiens (human)
ITGAM hsa:3684 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
ITGAM hsa:3684 path:hsa05221 Acute myeloid leukemia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITGAM IRAK1 11701612 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGAM SPI1 10411939 17203216 19747912 21402070 23180781 8095266 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay,electrophoretic mobility shift assay InnateDB
ITGAM CEACAM8 18056392 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGAM LGALS3 18025226 23180781 physical association solid phase assay InnateDB
ITGAM SP3 23180781 9295357 physical association electrophoretic mobility supershift assay InnateDB
ITGAM SP1 23180781 9295357 physical association electrophoretic mobility supershift assay InnateDB
ITGAM BCAP31 15294914 23180781 physical association anti tag coimmunoprecipitation,enzyme linked immunosorbent assay InnateDB
ITGB2 ITGAM 18209068 18644795 23180781 physical association anti tag coimmunoprecipitation,fluorescent resonance energy transfer InnateDB
VAV1 ITGAM 19747912 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility supershift assay InnateDB
ITGAM ITGB2 18083624 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGAM TGFBI 18083624 23180781 physical association anti tag coimmunoprecipitation InnateDB
CD14 ITGAM 11745332 23180781 physical association fluorescent resonance energy transfer InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 ITGAM 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ITGAM 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITGAM 15163413 18971253 8095266 9295016 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ITGAM 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RELB ITGAM N/A trascriptional regulation,stimulation inferred by curator TFlink
SP1 ITGAM N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
LMNA ITGAM 25348397 N/A physical interaction ComPPI
RAD21 ITGAM 25348397 N/A physical interaction ComPPI
KASH5 ITGAM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ELANE ITGAM 14525934 15718918 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PLAUR ITGAM 10744708 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GJB1 ITGAM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB2 ITGAM 25348397 N/A in vivo ComPPI
C3 ITGAM 11073102 14525934 25348397 4062888 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRAK1 ITGAM 11701612 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRTN3 ITGAM 25348397 N/A physical interaction ComPPI
BCAP31 ITGAM 15294914 25348397 27898060 N/A physical interaction ComPPI,OmniPath
AUP1 ITGAM 25348397 N/A two hybrid,physical interaction ComPPI
SYT2 ITGAM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KCNJ6 ITGAM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM ICAM4 10846180 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ITGAM CFH 14525934 25348397 27898060 9558116 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ITGAM FGG 11073102 14525934 25348397 27898060 9712878 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
ITGAM HP 11967116 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ITGAM ICAM2 10352278 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGAM ICAM1 11073102 14525934 25348397 9488691 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITGAM JAM3 25348397 N/A physical interaction,in vitro,in vivo ComPPI
ITGAM CD209 14525934 16246332 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ITGAM CLEC4M 16246332 24234451 25348397 physical association anti bait coimmunoprecipitation,in vitro ComPPI,IntAct
ITGAM SHARPIN 25348397 N/A physical interaction ComPPI
ITGAM REEP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM ERGIC3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM REEP4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM CERS4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM RUSF1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM PGRMC2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM CREB3L1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM MMGT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM KIR2DL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM GORAB 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM MRM1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM ARL13B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM DKK4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM CD79A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM SCN3B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM SLC10A6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM TMEM52B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM CLRN1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM TMEM229B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM GJA8 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM GPR42 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM AQP6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM ELOVL4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MGST3 ITGAM 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGAM THY1 14525934 15004192 N/A experimental interaction detection HPRD
ITGAM LGALS3 18025226 27898060 N/A N/A OmniPath
GP1BA ITGAM 10899906 27898060 N/A N/A OmniPath
ITGAM CEACAM8 18056392 27898060 N/A N/A OmniPath
SPI1 ITGAM 15676205 27898060 stimulant N/A OmniPath
ITGB2 ITGAM 12736251 18083624 18209068 18644795 2454931 27898060 N/A N/A OmniPath
ITGAM ITGB2 12736251 18083624 18209068 18644795 2454931 27898060 N/A N/A OmniPath
DDIT3 ITGAM 19359519 27898060 stimulant N/A OmniPath
CD14 ITGAM 11745332 27898060 N/A N/A OmniPath
ITGAM IRAK1 11701612 27898060 N/A N/A OmniPath
IRAK1 ITGAM 11701612 27898060 N/A N/A OmniPath
ITGAM ICAM1 11073102 23994464 27898060 9488691 stimulant N/A OmniPath
FGA ITGAM 16601240 27898060 N/A N/A OmniPath
FGB ITGAM 16601240 27898060 N/A N/A OmniPath

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