Gene Information gene info

  1. Home

GENE：ITGAV

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITGAV
FullNmae integrin subunit alpha V
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6150
EnsembleID ENSG00000138448
Uniprot P06756

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITGAV apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITGAV apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ITGAV GO:0001525,GO:0001525,GO:0001570,GO:0001618,GO:0001846,GO:0001968,GO:0002020,GO:0005080,GO:0005178,GO:0005178,GO:0005245,GO:0005515,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0005925,GO:0007155,GO:0007160,GO:0007160,GO:0007160,GO:0007204,GO:0007229,GO:0007229,GO:0007229,GO:0007229,GO:0008284,GO:0008305,GO:0008305,GO:0008305,GO:0009897,GO:0009986,GO:0009986,GO:0009986,GO:0010745,GO:0010888,GO:0015026,GO:0016020,GO:0016477,GO:0017134,GO:0019960,GO:0030335,GO:0031258,GO:0031527,GO:0031528,GO:0031589,GO:0031994,GO:0032369,GO:0032587,GO:0033627,GO:0033627,GO:0033690,GO:0034113,GO:0034446,GO:0034683,GO:0034684,GO:0034685,GO:0034686,GO:0034686,GO:0035579,GO:0035866,GO:0035867,GO:0035868,GO:0035987,GO:0038027,GO:0038132,GO:0043277,GO:0043277,GO:0045335,GO:0045785,GO:0046718,GO:0046718,GO:0046872,GO:0050431,GO:0050748,GO:0050764,GO:0050840,GO:0050919,GO:0051057,GO:0070062,GO:0070371,GO:0070588,GO:0071604,GO:0085017,GO:0097192,GO:0098609,GO:1901388,GO:1902533,GO:1905598,GO:1990430,GO:2000536,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITGAV hsa:3685 path:hsa04145 Phagosome - Homo sapiens (human)
ITGAV hsa:3685 path:hsa04148 Efferocytosis - Homo sapiens (human)
ITGAV hsa:3685 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
ITGAV hsa:3685 path:hsa04510 Focal adhesion - Homo sapiens (human)
ITGAV hsa:3685 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
ITGAV hsa:3685 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
ITGAV hsa:3685 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ITGAV hsa:3685 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05163 Human cytomegalovirus infection - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05200 Pathways in cancer - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05222 Small cell lung cancer - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
ITGAV hsa:3685 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITGAV ITGB3 10022831 10545505 10837075 11146654 11335727 11532940 11553709 12000961 14697347 15031725 16919435 18353785 19161977 19339212 19449109 22035837 26192618 7512751 7529872 7657702 8636223 8755653 9295024 9763615 interaction type N/A ACSN
ITGAV ITGB5 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGAV ITGB6 26192618 association N/A ACSN
ITGAV L1CAM 11553709 19161977 26192618 8636223 9003039 association N/A ACSN
ITGAV CRK 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGAV DOCK1 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGAV BCAR1 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGAV LGALS8 18849583 23180781 physical association pull down InnateDB
ITGAV IL32 22203669 23180781 physical association enzyme linked immunosorbent assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR ITGAV 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ITGAV 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ITGAV 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ITGAV 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ITGAV 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOSL1 ITGAV 23319049 trascriptional regulation,stimulation inferred by curator TFlink
HOXD3 ITGAV 14610084 trascriptional regulation,stimulation inferred by curator TFlink
JUND ITGAV 23319049 trascriptional regulation,stimulation inferred by curator TFlink
SP1 ITGAV 12136940 23319049 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 ITGAV 12136940 23319049 trascriptional regulation,stimulation inferred by curator TFlink
SP3 ITGAV 12136940 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001E0AEA ITGAV 17612493 22473208 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS00000F31F4 ITGAV 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 ITGAV 19074876 25416803 26506238 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,miRNA interference luciferase reporter assay TarBase
URS00002FC5B0 ITGAV 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00002C02E4 ITGAV 25416803 27310302 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001A7F58 ITGAV 25416803 26934001 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
ITGB8 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV ITGB8 25361965 interaction type N/A PTMCode2
MMP2 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV MMP2 25361965 interaction type N/A PTMCode2
ITGAV ITGB3 25361965 interaction type N/A PTMCode2
ITGB3 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV ITGB6 25361965 interaction type N/A PTMCode2
ITGB6 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV THY1 25361965 interaction type N/A PTMCode2
THY1 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV ITGB5 25361965 interaction type N/A PTMCode2
ITGB5 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV EDIL3 25361965 interaction type N/A PTMCode2
EDIL3 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV MMP14 25361965 interaction type N/A PTMCode2
MMP14 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV F2R 25361965 interaction type N/A PTMCode2
F2R ITGAV 25361965 interaction type N/A PTMCode2
ITGAV CD47 25361965 interaction type N/A PTMCode2
CD47 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV ANGPTL3 25361965 interaction type N/A PTMCode2
ANGPTL3 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV ITGB1 25361965 interaction type N/A PTMCode2
ITGB1 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV SPP1 25361965 interaction type N/A PTMCode2
SPP1 ITGAV 25361965 interaction type N/A PTMCode2
TGFB1 ITGAV 25361965 interaction type N/A PTMCode2
ITGAV TGFB1 25361965 interaction type N/A PTMCode2
VTN ITGAV 25361965 interaction type N/A PTMCode2
ITGAV VTN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
STAT1 ITGAV 25348397 N/A physical interaction ComPPI
TGFB1 ITGAV 11970960 14525934 21677751 24234451 25348397 physical association transmission electron microscopy,experimental interaction detection,molecular sieving,in vivo ComPPI,HPRD,IntAct
ITGB5 ITGAV 14525934 1694173 24234451 25348397 7689573 association,physical association experimental interaction detection,chromatography technology,physical interaction,in vitro,solid phase assay ComPPI,HPRD,IntAct
MMP14 ITGAV 11741954 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
ERBB2 ITGAV 25348397 N/A physical interaction ComPPI
CBL ITGAV 25348397 N/A physical interaction ComPPI
MAPK1 ITGAV 25348397 N/A physical interaction ComPPI
CCN3 ITGAV 25348397 N/A physical interaction ComPPI
SHC1 ITGAV 25348397 N/A physical interaction ComPPI
MAPK3 ITGAV 25348397 N/A physical interaction ComPPI
EP300 ITGAV 25348397 N/A physical interaction ComPPI
ITGB1 ITGAV 22178926 24234451 25348397 physical association pull down,physical interaction,in vivo ComPPI,IntAct
SPP1 ITGAV 10835423 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITGAV ITGB3 11546839 11884718 14525934 15299032 16099422 1694173 20639902 22178926 24234451 24658351 25348397 9686320 physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,in vitro,solid phase assay ComPPI,HPRD,IntAct
ITGAV PDGFRA 11953315 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGAV F2R 11278329 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
ITGAV AZGP1 25348397 27898060 9813179 N/A in vitro ComPPI,OmniPath
ITGAV PLP1 12196561 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITGAV L1CAM 10871287 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
ITGAV P2RY2 25348397 N/A in vitro,in vivo ComPPI
ITGAV CD47 10545994 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGAV AUP1 25348397 N/A two hybrid,physical interaction ComPPI
ITGAV ITGB8 14525934 1918072 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
ITGAV PAK4 12356872 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
ITGAV CCN1 10821835 11287419 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
ITGAV EDIL3 11959660 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ITGAV ANGPTL3 11877390 14525934 24234451 25348397 physical association experimental interaction detection,enzyme linked immunosorbent assay,in vivo ComPPI,HPRD,IntAct
ITGAV CALR 12196561 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGAV ICAM4 11435317 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGAV MMP2 11134507 14525934 22349830 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
ITGAV ADAM9 14525934 15361064 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ITGAV NID1 14525934 25348397 9686320 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGAV ITGB6 14525934 1532572 21677751 24234451 25348397 25383667 8120056 physical association transmission electron microscopy,experimental interaction detection,molecular sieving,x-ray crystallography,physical interaction,ion exchange chromatography,in vivo ComPPI,HPRD,IntAct
ITGAV ILK 25348397 N/A physical interaction ComPPI
ITGAV CSF1R 25348397 N/A physical interaction ComPPI
ITGAV BCAR1 25348397 N/A physical interaction ComPPI
ITGAV PHKA2 25348397 N/A physical interaction ComPPI
ITGAV PXN 25348397 N/A physical interaction ComPPI
ITGAV FBXO6 25348397 N/A physical interaction ComPPI
ITGAV MCAT 25348397 N/A physical interaction ComPPI
ITGAV KRT3 25348397 N/A physical interaction ComPPI
ITGAV FN1 1694173 19738201 24234451 24658351 25348397 association,physical association cross-linking study,molecular sieving,x-ray crystallography,physical interaction,solid phase assay ComPPI,IntAct
ITGAV THBS1 25348397 N/A physical interaction ComPPI
ITGAV EPHA2 25348397 N/A physical interaction ComPPI
ITGAV TAZ 25348397 N/A physical interaction ComPPI
ITGAV SUSD4 25348397 N/A physical interaction ComPPI
ITGAV DPEP2 25348397 N/A physical interaction ComPPI
ITGAV NTRK1 25348397 N/A physical interaction ComPPI
ITGAV PSMD12 25348397 N/A physical interaction ComPPI
ITGAV LGALS3BP 25348397 N/A physical interaction ComPPI
ITGAV NCOR1 25348397 N/A physical interaction ComPPI
ITGAV NCOR2 25348397 N/A physical interaction ComPPI
ITGAV PTK2 23397142 24234451 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
ITGAV PLA2G2A 25348397 N/A physical interaction ComPPI
ITGAV ANGPT2 25348397 N/A physical interaction ComPPI
ITGAV NCL 25348397 N/A physical interaction ComPPI
ITGAV TNFSF13B 25348397 N/A physical interaction ComPPI
ITGAV LYZL2 25348397 N/A physical interaction ComPPI
ITGAV NAAA 25348397 N/A physical interaction ComPPI
ITGAV DEFA1 25348397 N/A physical interaction ComPPI
ITGAV ST3GAL1 25348397 N/A physical interaction ComPPI
ITGAV GGH 25348397 N/A physical interaction ComPPI
ITGAV TMEM25 25348397 N/A physical interaction ComPPI
ITGAV ST8SIA4 25348397 N/A physical interaction ComPPI
ITGAV TCTN2 25348397 N/A physical interaction ComPPI
ITGAV INSL5 25348397 N/A physical interaction ComPPI
ITGAV FCGR3B 25348397 N/A physical interaction ComPPI
ITGAV FUT8 25348397 N/A physical interaction ComPPI
ITGAV PTCH1 25348397 N/A physical interaction ComPPI
ITGAV B3GNT2 25348397 N/A physical interaction ComPPI
ITGAV UBC 25348397 N/A physical interaction ComPPI
ITGAV ITGA4 25348397 N/A physical interaction ComPPI
ITGAV AGMAT 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ITGAV TRIM25 25348397 N/A physical interaction ComPPI
ITGAV VWF 1694173 24234451 25348397 physical association solid phase assay ComPPI,IntAct
ITGAV PTPRZ1 20639902 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ITGAV PLPP3 16099422 24234451 25348397 physical association enzyme linked immunosorbent assay ComPPI,IntAct
ITGAV FGG 24234451 24789099 25348397 physical association fluorescence-activated cell sorting ComPPI,IntAct
ITGAV TGFB3 24234451 25348397 25383667 N/A x-ray crystallography ComPPI,IntAct
ITGAV LAMP1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
VTN ITGAV 1694173 24234451 25348397 physical association solid phase assay ComPPI,IntAct
THY1 ITGAV 14525934 15897908 N/A experimental interaction detection HPRD
FN1 ITGAV 1532572 1694173 17015452 18480047 23154389 27898060 stimulant N/A OmniPath
FGG ITGAV 15031111 27898060 N/A N/A OmniPath
ADAM15 ITGAV 27898060 9914169 N/A N/A OmniPath
FGA ITGAV 15031111 27898060 N/A N/A OmniPath
VTN ITGAV 23154389 27898060 stimulant N/A OmniPath
ITGAV ITGB5 11162558 1694173 27898060 7689573 N/A N/A OmniPath
ITGB5 ITGAV 11162558 1694173 27898060 7689573 N/A N/A OmniPath
FBN1 ITGAV 18653538 20686071 27898060 8617364 N/A N/A OmniPath
ADAM9 ITGAV 11162558 15361064 27898060 stimulant N/A OmniPath
COL4A1 ITGAV 14610079 27898060 stimulant N/A OmniPath
MFGE8 ITGAV 24441829 27898060 N/A N/A OmniPath
FGB ITGAV 15031111 27898060 N/A N/A OmniPath
COL4A3 ITGAV 12842087 27898060 N/A N/A OmniPath

Visualization










  Return