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GENE：CASP10

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CASP10
FullNmae caspase 10
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1500
EnsembleID ENSG00000003400
Uniprot Q92851

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CASP10 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP10 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CASP10 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
CASP10 GO:0004197,GO:0005515,GO:0005737,GO:0005829,GO:0006508,GO:0006915,GO:0006915,GO:0006919,GO:0008625,GO:0030225,GO:0031265,GO:0031625,GO:0035877,GO:0035877,GO:0042981,GO:0043123,GO:0051604,GO:0097153,GO:0097199,GO:0097199,GO:0097342

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CASP10 hsa:843 path:hsa04210 Apoptosis - Homo sapiens (human)
CASP10 hsa:843 path:hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human)
CASP10 hsa:843 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
CASP10 hsa:843 path:hsa05152 Tuberculosis - Homo sapiens (human)
CASP10 hsa:843 path:hsa05161 Hepatitis B - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CASP10 TRAF1 11098060 23180781 cleavage reaction cleavage reaction InnateDB
MAP3K14 CASP10 11002417 23180781 physical association anti tag coimmunoprecipitation InnateDB
RIPK1 CASP10 11002417 23180781 physical association anti tag coimmunoprecipitation InnateDB
DEDD2 CASP10 12527898 23180781 physical association anti tag coimmunoprecipitation InnateDB
FADD CASP10 16585540 23180781 physical association two hybrid InnateDB
IFT57 CASP10 17898872 23180781 physical association classical fluorescence spectroscopy InnateDB
GZMB CASP10 15569669 23180781 8755496 protein cleavage protease assay InnateDB
CASP3 CASP10 23180781 8755496 protein cleavage protease assay InnateDB
CASP10 CASP10 23180781 8755496 protein cleavage protease assay InnateDB
CASP8 CASP10 22421964 23180781 physical association anti tag coimmunoprecipitation InnateDB
CASP10 RIOK3 21988832 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
XIAP CASP10 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
GATA2 CASP10 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 CASP10 14688482 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CASP10 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CASP10 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CASP10 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000021D7C8 CASP10 20878113 22743998 mrna cleavage,inhibition N/A miRDeathDB
URS000031BC7D CASP10 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS00000ECE9C CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000013D17D CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006FDD4 CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000E1E9E CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 CASP10 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004F507C CASP10 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000F4AC3 CASP10 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000072B4C8 CASP10 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E CASP10 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 CASP10 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 CASP10 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
TNFSF10 CASP10 25361965 interaction type N/A PTMCode2
CASP10 TNFSF10 25361965 interaction type N/A PTMCode2
CASP10 FADD 25361965 interaction type N/A PTMCode2
FADD CASP10 25361965 interaction type N/A PTMCode2
CASP10 CASP3 25361965 interaction type N/A PTMCode2
CASP3 CASP10 25361965 interaction type N/A PTMCode2
CASP10 CFLAR 25361965 interaction type N/A PTMCode2
CFLAR CASP10 25361965 interaction type N/A PTMCode2
CASP10 BID 25361965 interaction type N/A PTMCode2
BID CASP10 25361965 interaction type N/A PTMCode2
CASP10 CASP8 25361965 interaction type N/A PTMCode2
CASP8 CASP10 25361965 interaction type N/A PTMCode2
CASP10 FASLG 25361965 interaction type N/A PTMCode2
FASLG CASP10 25361965 interaction type N/A PTMCode2
CASP10 DEDD 25361965 interaction type N/A PTMCode2
DEDD CASP10 25361965 interaction type N/A PTMCode2
RIPK1 CASP10 25361965 interaction type N/A PTMCode2
CASP10 RIPK1 25361965 interaction type N/A PTMCode2
TNFRSF10A CASP10 25361965 interaction type N/A PTMCode2
CASP10 TNFRSF10A 25361965 interaction type N/A PTMCode2
TNFRSF1A CASP10 25361965 interaction type N/A PTMCode2
CASP10 TNFRSF1A 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
OIP5 CASP10 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP14 CASP10 14525934 25348397 9792675 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
XIAP CASP10 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CASP9 CASP10 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RYBP CASP10 11395500 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK8 CASP10 25348397 N/A physical interaction ComPPI
CASP3 CASP10 14525934 25348397 8755496 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RB1 CASP10 14525934 15735701 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RHOA CASP10 25348397 N/A physical interaction ComPPI
ARHGDIA CASP10 25348397 N/A physical interaction ComPPI
CASP1 CASP10 25348397 N/A physical interaction ComPPI
CASP6 CASP10 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP7 CASP10 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP8 CASP10 11717445 12198154 12887920 14525934 170210 17159907 24234451 25348397 3031469 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TNFRSF1A CASP10 11098060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FADD CASP10 11717445 14525934 15069192 24234451 25348397 9045686 physical association two hybrid,coimmunoprecipitation,experimental interaction detection,fluorescent resonance energy transfer,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
TRAF1 CASP10 11098060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
FASLG CASP10 16498403 24234451 25348397 physical association anti tag coimmunoprecipitation,coimmunoprecipitation,physical interaction ComPPI,IntAct
POLR2A CASP10 14525934 25348397 9153302 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CASP10 CASP4 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP10 DEDD 12527898 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CASP10 CCAR1 14525934 15069192 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP10 DEDD2 12527898 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP10 BFAR 10716992 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CASP10 DSP 14525934 15500642 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CASP10 TNFRSF10B 25348397 N/A physical interaction ComPPI
CASP10 BID 14525934 15772077 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
CASP10 EZR 25348397 N/A physical interaction ComPPI
CASP10 FAS 11717445 24234451 25348397 association coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP10 MSN 25348397 N/A physical interaction ComPPI
CASP10 TNFRSF10A 19427028 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CASP10 RIPK1 12884866 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
CASP10 CASP8AP2 15069192 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP10 RNF34 15069192 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASP10 RIOK3 19557502 21988832 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,confocal microscopy ComPPI,IntAct
CASP10 ECE2 25348397 N/A two hybrid,physical interaction ComPPI
CASP10 NFKBIL1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP10 PHF20L1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CASP10 PRDX6 25348397 N/A physical interaction ComPPI
CASP10 BIRC2 25348397 N/A physical interaction ComPPI
CASP10 BIRC3 25348397 N/A physical interaction ComPPI
CASP10 TNFSF10 23678861 24234451 25348397 association coimmunoprecipitation,pull down ComPPI,IntAct
CASP10 EDA2R 25348397 N/A coimmunoprecipitation ComPPI
CASP10 BCLAF1 23541952 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MAP3K14 CASP10 12884866 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
CASP2 CASP10 14525934 25348397 8962078 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CFLAR CASP10 12887920 14525934 23541952 24234451 25241761 25348397 9208847 9228018 9289491 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
SERPINB9 CASP10 25348397 N/A physical interaction ComPPI
CASP10 CASP10 11717445 14525934 24234451 8755496 9045686 N/A experimental interaction detection,fluorescent resonance energy transfer HPRD,IntAct
EEF1AKMT4-ECE2 CASP10 21988832 24234451 physical association two hybrid array IntAct
FADD CASP10 11717445 15069192 15659383 16585540 20829884 27898060 9045686 9228018 stimulant N/A OmniPath
CASP10 FADD 11717445 15069192 15659383 16585540 20829884 27898060 9045686 9228018 N/A N/A OmniPath
GZMB CASP10 15569669 27898060 8755496 stimulant N/A OmniPath
CASP10 CASP7 27898060 8755496 8962078 stimulant N/A OmniPath
CASP10 MAP3K14 11002417 12884866 27898060 stimulant N/A OmniPath
MAP3K14 CASP10 11002417 12884866 27898060 N/A N/A OmniPath
CASP3 CASP10 11717445 27898060 8755496 9765224 9922454 stimulant N/A OmniPath
CASP10 CASP3 11717445 27898060 8755496 9765224 9922454 stimulant N/A OmniPath
CASP10 BID 15772077 16186808 27898060 stimulant N/A OmniPath
TP53 CASP10 14688482 27898060 stimulant N/A OmniPath
CASP8 CASP10 11717445 11832478 12198154 12887920 15280356 15659383 170210 17159907 21737330 22421964 22864571 27898060 3031469 8962078 stimulant N/A OmniPath
CASP10 CASP8 11717445 11832478 12198154 12887920 15280356 15659383 170210 17159907 21737330 22421964 22864571 27898060 3031469 8962078 N/A N/A OmniPath
RIPK1 CASP10 11002417 12884866 27898060 stimulant N/A OmniPath
CASP10 RIPK1 11002417 12884866 16186808 27898060 inhibition N/A OmniPath
CFLAR CASP10 12887920 21737330 23541952 25241761 27898060 9208847 9228018 9289491 inhibition N/A OmniPath
CASP10 RIOK3 21988832 27898060 N/A N/A OmniPath
CASP10 TRAF1 11098060 27898060 N/A N/A OmniPath
DEDD2 CASP10 12527898 27898060 N/A N/A OmniPath
CASP10 DEDD2 12527898 27898060 N/A N/A OmniPath

Visualization










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