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GENE：LTBR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LTBR
FullNmae lymphotoxin beta receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6718
EnsembleID ENSG00000111321
Uniprot P36941

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LTBR apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
LTBR apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
LTBR GO:0005515,GO:0005794,GO:0005886,GO:0006915,GO:0006955,GO:0007165,GO:0031625,GO:0031625,GO:0042802,GO:0043011,GO:0043123,GO:0043123,GO:0046330,GO:0048534,GO:0071260,GO:2001238

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LTBR hsa:4055 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
LTBR hsa:4055 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
LTBR hsa:4055 path:hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
LTBR hsa:4055 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
LTBR hsa:4055 path:hsa04672 Intestinal immune network for IgA production - Homo sapiens (human)
LTBR hsa:4055 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
LTBR hsa:4055 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LTBR TRAF3 10753918 12571250 14517219 15743811 23180781 9388227 physical association anti tag coimmunoprecipitation,pull down InnateDB
LTBR TRAF2 12571250 14517219 15743811 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
LTBR TRAF5 14517219 23180781 physical association pull down InnateDB
LTBR LTBR 12571250 14517219 23180781 26467481 bind,physical association,up-regulates activity pull down InnateDB,Signor
LTBR CHUK 15743811 23180781 physical association anti tag coimmunoprecipitation InnateDB
LTBR IKBKB 15743811 23180781 physical association anti tag coimmunoprecipitation InnateDB
TNFSF14 LTBR 12571250 23180781 physical association anti tag coimmunoprecipitation InnateDB
LTBR DIABLO 12571250 23180781 physical association anti tag coimmunoprecipitation InnateDB
LTBR BIRC2 12571250 23180781 physical association anti tag coimmunoprecipitation InnateDB
LTB LTBR 23180781 8171323 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
TRAF1 LTBR 20005715 interaction type N/A PSP
TRAF2 LTBR 20005715 interaction type N/A PSP
TRAF5 LTBR 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
AR LTBR 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 LTBR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LTBR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF LTBR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LTBR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LTBR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LTBR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF LTBR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
WWTR1 LTBR 22470139 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 LTBR 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000214763 LTBR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000047A8F LTBR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A LTBR 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 LTBR 25416803 28097098 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
LTBR TRAF4 25361965 interaction type N/A PTMCode2
TRAF4 LTBR 25361965 interaction type N/A PTMCode2
LTBR DIABLO 25361965 interaction type N/A PTMCode2
DIABLO LTBR 25361965 interaction type N/A PTMCode2
LTBR TRAF3 25361965 interaction type N/A PTMCode2
TRAF3 LTBR 25361965 interaction type N/A PTMCode2
BIRC2 LTBR 25361965 interaction type N/A PTMCode2
LTBR BIRC2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TCHP LTBR 25348397 N/A physical interaction ComPPI
RABAC1 LTBR 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ARHGEF18 LTBR 25348397 N/A physical interaction ComPPI
NBR1 LTBR 25348397 N/A physical interaction ComPPI
VAPA LTBR 25348397 N/A physical interaction ComPPI
MAP4K4 LTBR 25348397 N/A physical interaction ComPPI
HGS LTBR 25348397 N/A physical interaction ComPPI
UBB LTBR 25348397 N/A physical interaction ComPPI
CSNK1E LTBR 25348397 N/A physical interaction ComPPI
PLK1 LTBR 25348397 N/A physical interaction ComPPI
TRAF3 LTBR 12571250 14525934 20732415 24234451 25348397 9122217 physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
HNRNPL LTBR 25348397 N/A physical interaction ComPPI
MKI67 LTBR 25348397 N/A physical interaction ComPPI
TNF LTBR 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
BLZF1 LTBR 25348397 N/A physical interaction ComPPI
SDCBP LTBR 25348397 N/A physical interaction ComPPI
TNIK LTBR 25348397 N/A physical interaction ComPPI
TRAF1 LTBR 25348397 N/A physical interaction ComPPI
TRAF2 LTBR 12169272 14525934 20732415 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
ODF2 LTBR 25348397 N/A physical interaction ComPPI
VAPB LTBR 25348397 N/A physical interaction ComPPI
FGFR1 LTBR 25348397 N/A physical interaction ComPPI
TRAF5 LTBR 14517219 14525934 25348397 27898060 8663299 9162022 9511754 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
TAOK2 LTBR 25348397 N/A physical interaction ComPPI
TRAF4 LTBR 14525934 25348397 9626059 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DIABLO LTBR 12571250 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HDAC5 LTBR 25348397 N/A physical interaction ComPPI
NFKB2 LTBR 20818435 24234451 25348397 association immunodepleted coimmunoprecipitation ComPPI,IntAct
TRIM25 LTBR 25348397 N/A physical interaction ComPPI
BIRC2 LTBR 12571250 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ZMYND11 LTBR 20732415 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
LTBR LTB 14525934 25348397 7916655 N/A experimental interaction detection,in vitro ComPPI,HPRD
LTBR TNFSF14 10318773 10799510 14525934 24234451 25348397 26977880 9462508 physical association experimental interaction detection,yeast display,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,HPRD,IntAct
LTBR LTA 14525934 25348397 8171323 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LTBR TRIM37 25348397 N/A physical interaction ComPPI
LTBR HES1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LTBR ZNF865 25348397 N/A physical interaction ComPPI
LTBR CCDC93 25348397 N/A physical interaction ComPPI
LTBR SPATS2 25348397 N/A physical interaction ComPPI
LTBR CEP131 25348397 N/A physical interaction ComPPI
LTBR PRC1 25348397 N/A physical interaction ComPPI
LTBR ZWINT 25348397 N/A physical interaction ComPPI
LTBR POM121 25348397 N/A physical interaction ComPPI
LTBR ZC3H3 25348397 N/A physical interaction ComPPI
LTBR CEP120 25348397 N/A physical interaction ComPPI
LTBR SPATS2L 25348397 N/A physical interaction ComPPI
LTBR ZMYM6 25348397 N/A physical interaction ComPPI
LTBR MAP7D1 25348397 N/A physical interaction ComPPI
LTBR MGA 25348397 N/A physical interaction ComPPI
LTBR CEP95 25348397 N/A physical interaction ComPPI
LTBR POLRMT 25348397 N/A physical interaction ComPPI
LTBR IQCB1 25348397 N/A physical interaction ComPPI
LTBR SLTM 25348397 N/A physical interaction ComPPI
LTBR CCDC121 25348397 N/A physical interaction ComPPI
LTBR RFT1 25348397 N/A physical interaction ComPPI
LTBR IKBKG 25348397 N/A physical interaction ComPPI
LTBR TBC1D31 25348397 N/A physical interaction ComPPI
LTBR CCDC112 25348397 N/A physical interaction ComPPI
LTBR RNF31 25348397 N/A physical interaction ComPPI
LTBR RNF166 25348397 N/A physical interaction ComPPI
LTBR SHARPIN 25348397 N/A physical interaction ComPPI
LTBR IFT81 25348397 N/A physical interaction ComPPI
LTBR CCHCR1 25348397 N/A physical interaction ComPPI
LTBR THAP3 25348397 N/A physical interaction ComPPI
LTBR CCDC113 25348397 N/A physical interaction ComPPI
LTBR SPC25 25348397 N/A physical interaction ComPPI
LTBR TRIM4 25348397 N/A physical interaction ComPPI
LTBR CCDC77 25348397 N/A physical interaction ComPPI
LTBR CISD2 25348397 N/A physical interaction ComPPI
LTBR SKI 25348397 N/A physical interaction ComPPI
LTBR EGFL7 25348397 N/A physical interaction ComPPI
LTBR RBCK1 25348397 N/A physical interaction ComPPI
LTBR TNFRSF10B 25348397 N/A physical interaction ComPPI
LTBR CTU1 25348397 N/A physical interaction ComPPI
LTBR TIGD5 25348397 N/A physical interaction ComPPI
LTBR CD320 25348397 N/A physical interaction ComPPI
LTBR RNF114 25348397 N/A physical interaction ComPPI
LTBR CEP78 25348397 N/A physical interaction ComPPI
LTBR MTNR1B 24234451 25348397 26514267 physical association two hybrid,physical interaction ComPPI,IntAct
LTBR DEAF1 20732415 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
LTBR LTBR 10207006 14525934 20732415 24234451 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,two hybrid HPRD,IntAct
LTBR CHUK 15743811 27898060 N/A N/A OmniPath
LTBR TRAF2 12169272 12571250 14517219 15743811 20348096 20732415 26186194 27898060 9162022 stimulant N/A OmniPath
LTBR MAP3K14 12387745 27898060 stimulant N/A OmniPath
TNFSF14 LTBR 10318773 10799510 12571250 27898060 9462508 9739048 stimulant N/A OmniPath
BIRC2 LTBR 12571250 27898060 N/A N/A OmniPath
LTA LTBR 27898060 7995952 8171323 stimulant N/A OmniPath
LTB LTBR 12387745 27898060 7916655 7995952 8171323 stimulant N/A OmniPath
LTBR TRAF3 10753918 12571250 14517219 15743811 20348096 20732415 26186194 27898060 7859281 9122217 9162022 9388227 N/A N/A OmniPath
TRAF3 LTBR 10753918 12571250 14517219 15743811 20348096 20732415 26186194 27898060 7859281 9122217 9162022 9388227 N/A N/A OmniPath
LTBR IKBKB 15743811 27898060 N/A N/A OmniPath

Visualization










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