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GENE：MAP3K5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K5
FullNmae mitogen-activated protein kinase kinase kinase 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6857
EnsembleID ENSG00000197442
Uniprot Q99683

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K5 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K5 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K5 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MAP3K5 GO:0000165,GO:0000287,GO:0002931,GO:0004672,GO:0004674,GO:0004706,GO:0004709,GO:0004709,GO:0005515,GO:0005524,GO:0005737,GO:0005829,GO:0006468,GO:0007254,GO:0007254,GO:0008631,GO:0008631,GO:0009897,GO:0010666,GO:0019901,GO:0019903,GO:0019904,GO:0032991,GO:0033554,GO:0034198,GO:0034976,GO:0036480,GO:0038066,GO:0042802,GO:0042803,GO:0043065,GO:0043280,GO:0043507,GO:0045087,GO:0045663,GO:0045860,GO:0045893,GO:0046330,GO:0051402,GO:0051403,GO:0070059,GO:0070301,GO:0071356,GO:0072577,GO:0090398,GO:0097190,GO:0097300,GO:0106310,GO:1900745,GO:1902170,GO:1902911,GO:1904707,GO:1990604

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K5 hsa:4217 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04210 Apoptosis - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04530 Tight junction - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04668 TNF signaling pathway - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04714 Thermogenesis - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa04936 Alcoholic liver disease - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05010 Alzheimer disease - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05012 Parkinson disease - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05016 Huntington disease - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)
MAP3K5 hsa:4217 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K5 TXN 11274345 12556535 12655147 18792398 20414655 26192618 association N/A ACSN
MAP3K5 TNFRSF1B 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23850759 24378531 26192618 interaction type N/A ACSN
TRAF2 MAP3K5 11274345 12556535 12655147 12738796 14730360 15310755 15592525 17462996 17700517 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23180781 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type,physical association anti tag coimmunoprecipitation ACSN,InnateDB
RIPK1 MAP3K5 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TNFRSF1A MAP3K5 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
TRADD MAP3K5 11274345 12556535 12655147 12738796 14730360 15592525 17462996 18641653 18855897 19392652 19524513 19632174 21133840 21232017 21614932 23010170 23850759 24378531 26192618 26587781 26653790 28574505 28765050 interaction type N/A ACSN
IGF1R MAP3K5 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617 26192618 interaction type N/A ACSN
MAP3K5 MAP2K4 11274345 12556535 12655147 12738796 12878192 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23331499 23850759 24378531 26192618 interaction type,stimulation N/A ACSN,SignaLink
MAP3K5 MAP2K3 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23331499 23850759 24378531 26192618 8974401 interaction type,stimulation N/A ACSN,SignaLink
MAP3K5 MAP2K7 11274345 11959862 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21071413 21133840 21232017 21614932 23331499 23850759 24378531 26192618 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
MAP3K5 MAP2K6 11274345 12556535 12655147 12738796 15592525 17462996 18641653 18855897 19392652 21133840 21232017 21614932 23331499 23850759 24378531 26192618 8974401 interaction type,stimulation N/A ACSN,SignaLink
MAP3K7 MAP3K5 10921914 23180781 physical association anti tag coimmunoprecipitation,two hybrid InnateDB
TRAF6 MAP3K5 10523862 10921914 23180781 physical association anti tag coimmunoprecipitation InnateDB
RAF1 MAP3K5 11427728 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K3 MAP3K5 16709866 19880523 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK14 MAP3K5 16709866 23180781 physical association anti tag coimmunoprecipitation InnateDB
GEMIN5 MAP3K5 17541429 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
MAP3K5 MAP3K5 14761963 17541429 17937911 19920149 23180781 26467481 8974401 phosphorylation reaction,physical association,up-regulates activity anti tag coimmunoprecipitation,protein kinase assay InnateDB,Signor
MAP2K4 MAP3K5 17541429 18408005 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
TPD52L1 MAP3K5 14761963 23180781 physical association anti tag coimmunoprecipitation,gst pull down InnateDB
BIRC5 MAP3K5 16540654 23180781 physical association anti tag coimmunoprecipitation InnateDB
GSPT1 MAP3K5 17700517 23180781 physical association anti tag coimmunoprecipitation InnateDB
AKT2 MAP3K5 12697749 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
ARRB2 MAP3K5 18408005 23180781 physical association gst pull down InnateDB
DAB2IP MAP3K5 15310755 23180781 physical association anti tag coimmunoprecipitation InnateDB
BIRC2 MAP3K5 17220297 23180781 physical association pull down InnateDB
AKT1 MAP3K5 11154276 23180781 phosphorylation reaction in-gel kinase assay InnateDB
JAK2 MAP3K5 19287004 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,protein kinase assay InnateDB
MAP3K5 JAK1 19287004 23180781 phosphorylation reaction protein kinase assay InnateDB
SOCS1 MAP3K5 19287004 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
PTPN11 MAP3K5 19287004 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
STRAP MAP3K5 19880523 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
TXN MAP3K5 12077134 19880523 23180781 physical association anti tag coimmunoprecipitation InnateDB
YWHAQ MAP3K5 19880523 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP MAP3K5 16049941 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K5 YWHAG 19935702 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP3K5 MAP3K6 19935702 23180781 physical association anti tag coimmunoprecipitation InnateDB
STAT5A MAP3K5 23180781 24497979 physical association anti tag coimmunoprecipitation InnateDB
DAXX MAP3K5 21071413 23331499 9743501 stimulation N/A SignaLink,SignaLink
SCO2 MAP3K5 23319048 phosphorylation reaction,stimulation N/A SignaLink
MAPK1 MAP3K5 16709866 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ARRB2 MAP3K5 20005715 interaction type N/A PSP
GADD45B MAP3K5 20005715 interaction type N/A PSP
MAPK8IP3 MAP3K5 12189133 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
TRAF1 MAP3K5 20005715 interaction type N/A PSP,SignaLink
TRAF2 MAP3K5 20005715 interaction type N/A PSP
TRAF3 MAP3K5 20005715 interaction type N/A PSP,SignaLink
TRAF5 MAP3K5 10523862 20005715 21071413 interaction type N/A PSP,SignaLink
TXN MAP3K5 20005715 interaction type N/A PSP
YWHAB MAP3K5 20005715 interaction type N/A PSP,SignaLink
YWHAE MAP3K5 20005715 interaction type N/A PSP
YWHAH MAP3K5 20005715 interaction type N/A PSP
YWHAQ MAP3K5 20005715 interaction type N/A PSP
YWHAZ MAP3K5 20005715 interaction type N/A PSP
ARRB2 MAP3K5 20005715 N/A N/A SignaLink
YWHAQ MAP3K5 20005715 20005715 N/A N/A SignaLink
YWHAZ MAP3K5 10411906 20005715 20005715 21071413 N/A N/A SignaLink
GADD45B MAP3K5 14743220 18988627 20005715 20005715 N/A N/A SignaLink
TRAF2 MAP3K5 10523862 20005715 20005715 21071413 N/A N/A SignaLink
YWHAE MAP3K5 15023544 18988627 20005715 20005715 N/A N/A SignaLink
YWHAH MAP3K5 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP3K5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F1 MAP3K5 16476732 16512785 17287612 18971253 19610065 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
E2F2 MAP3K5 16512785 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
E2F3 MAP3K5 16512785 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
E2F4 MAP3K5 16512785 18971253 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay,electrophoretic mobility shift assay TFlink
ESR1 MAP3K5 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 MAP3K5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP3K5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 MAP3K5 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 MAP3K5 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 MAP3K5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MAP3K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP3K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP3K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MAP3K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP3K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MAP3K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP3K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MAP3K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RB1 MAP3K5 19610065 trascriptional regulation,stimulation inferred by curator TFlink
MYC MAP3K5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004E008F MAP3K5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000042E1F MAP3K5 23087182 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000032FC1A MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003AA845 MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000453664 MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000E7139 MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041E949 MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000346991 MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C0FCB MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000034979B MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00003FA24D MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000048BA36 MAP3K5 21572407 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001C11BC MAP3K5 25416803 27775615 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 MAP3K5 25416803 25982447 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000435A77 MAP3K5 25416803 26148557 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000272039 MAP3K5 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKD1 MAP3K5 22135298 phosphorylation N/A PhosphoSite
JAK1 MAP3K5 22135298 phosphorylation N/A PhosphoSite
PDPK1 MAP3K5 22135298 phosphorylation N/A PhosphoSite
MAP3K5 DAXX 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP3K5 MAP2K3 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP3K5 MAPK8 22135298 phosphorylation N/A PhosphoSite
MAP3K5 MAP2K6 22135298 phosphorylation N/A PhosphoSite
MAP3K5 MAP3K5 22135298 phosphorylation N/A PhosphoSite
MAP3K5 STRAP 22135298 phosphorylation N/A PhosphoSite
MAP3K5 MAPK14 22135298 phosphorylation N/A PhosphoSite
MAP3K5 ZNF622 22135298 phosphorylation N/A PhosphoSite
MAP3K5 MAPRE1 22135298 phosphorylation N/A PhosphoSite
MAP3K5 PDPK1 22135298 phosphorylation N/A PhosphoSite
MAP3K5 CDKN1A 22135298 phosphorylation N/A PhosphoSite
MAP3K5 MAP2K4 22135298 phosphorylation N/A PhosphoSite
JAK2 MAP3K5 22135298 phosphorylation N/A PhosphoSite
PIM1 MAP3K5 22135298 phosphorylation N/A PhosphoSite
AKT2 MAP3K5 22135298 phosphorylation N/A PhosphoSite
AKT1 MAP3K5 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
RPS6KA3 MAP3K5 22135298 phosphorylation N/A PhosphoSite
DAXX MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K6 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 MAP3K6 25361965 interaction type N/A PTMCode2
MAP2K3 MAP3K5 25361965 interaction type N/A PTMCode2
GSTM1 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 GSTM1 25361965 interaction type N/A PTMCode2
PPP5C MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 PPP5C 25361965 interaction type N/A PTMCode2
RAF1 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 RAF1 25361965 interaction type N/A PTMCode2
TRAF5 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 TRAF5 25361965 interaction type N/A PTMCode2
CIB1 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 CIB1 25361965 interaction type N/A PTMCode2
MAP3K2 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 MAP3K2 25361965 interaction type N/A PTMCode2
DAB2IP MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 DAB2IP 25361965 interaction type N/A PTMCode2
GLRX MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 GLRX 25361965 interaction type N/A PTMCode2
YWHAB MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 YWHAB 25361965 interaction type N/A PTMCode2
MAP3K5 AKT1 25361965 interaction type N/A PTMCode2
RB1CC1 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 RB1CC1 25361965 interaction type N/A PTMCode2
YWHAH MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 YWHAH 25361965 interaction type N/A PTMCode2
DUSP19 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 DUSP19 25361965 interaction type N/A PTMCode2
TRAF6 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 TRAF6 25361965 interaction type N/A PTMCode2
ARRB2 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 ARRB2 25361965 interaction type N/A PTMCode2
STUB1 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 STUB1 25361965 interaction type N/A PTMCode2
AHRR MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 AHRR 25361965 interaction type N/A PTMCode2
MAP3K5 TXN 25361965 interaction type N/A PTMCode2
TXN MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 ARRB1 25361965 interaction type N/A PTMCode2
ARRB1 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 MAP2K7 25361965 interaction type N/A PTMCode2
MAP2K7 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 ERN1 25361965 interaction type N/A PTMCode2
ERN1 MAP3K5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DAXX MAP3K5 11003656 11495919 24234451 25241761 25348397 9743501 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,pull down,physical interaction,in vitro,in vivo,confocal microscopy,proximity ligation assay ComPPI,IntAct
SOCS3 MAP3K5 25348397 N/A physical interaction ComPPI
TXN2 MAP3K5 25348397 N/A physical interaction ComPPI
PRKAA2 MAP3K5 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPD52L2 MAP3K5 25348397 N/A physical interaction ComPPI
CDKN1A MAP3K5 12820963 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PSMC3 MAP3K5 25348397 N/A physical interaction ComPPI
TNFAIP3 MAP3K5 25348397 N/A physical interaction ComPPI
TRAF6 MAP3K5 10523862 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
GSTP1 MAP3K5 16636664 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAG MAP3K5 19935702 24234451 25348397 association coimmunoprecipitation,physical interaction ComPPI,IntAct
SMN1 MAP3K5 21496457 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
HSP90AB1 MAP3K5 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
EGLN3 MAP3K5 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
SOCS1 MAP3K5 16407264 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
PIK3R1 MAP3K5 25348397 N/A physical interaction ComPPI
PTPN11 MAP3K5 25348397 N/A physical interaction ComPPI
CREBBP MAP3K5 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
EP300 MAP3K5 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CIB1 MAP3K5 19805025 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
SIAH1 MAP3K5 25348397 N/A physical interaction ComPPI
GADD45B MAP3K5 14525934 14743220 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
YWHAB MAP3K5 15023544 21771788 24234451 25348397 association,physical association anti bait coimmunoprecipitation,two hybrid ComPPI,IntAct
GAPDH MAP3K5 25348397 N/A physical interaction ComPPI
YWHAZ MAP3K5 10411906 11336675 14525934 15023544 16449798 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
HSP90AA1 MAP3K5 25348397 N/A physical interaction ComPPI
EIF2AK2 MAP3K5 12473108 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP2K4 MAP3K5 25348397 N/A physical interaction ComPPI
HSPA1A MAP3K5 12391142 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
HSPA1B MAP3K5 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAP3K5 ARRB2 11356842 14525934 19782076 24234451 25348397 N/A experimental interaction detection,peptide array,physical interaction,in vivo ComPPI,HPRD,IntAct
MAP3K5 TXN 12089063 14525934 19805025 21771788 24234451 25348397 9564042 association,physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MAP3K5 TPD52L1 14525934 14761963 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP3K5 GLRX 12244106 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP3K5 PPP5C 11689443 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAP3K5 PDCD6 12372597 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP3K5 YWHAH 14525934 15023544 17700517 24234451 25348397 association,physical association two hybrid,coimmunoprecipitation,two hybrid ComPPI,HPRD,IntAct
MAP3K5 TRAF2 10523862 14525934 16636664 19805025 24234451 25348397 9774977 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MAP3K5 TRAF5 10523862 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K5 MAP3K3 12912994 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP3K5 MAP3K7 10921914 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MAP3K5 MAP2K7 17110930 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,in vitro,in vivo ComPPI,IntAct
MAP3K5 ERN1 12050113 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
MAP3K5 MAP3K6 14525934 17210579 24234451 25348397 25852190 9875215 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MAP3K5 YWHAE 14525934 15023544 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
MAP3K5 QARS1 11096076 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K5 DAB2IP 12813029 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
MAP3K5 MAP3K2 12912994 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP3K5 MAPK8IP3 12189133 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K5 DUSP19 11959862 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K5 CDC25A 11416155 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAP3K5 MAP2K6 14525934 15866172 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MAP3K5 TNNT2 12819028 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP3K5 SFN 14525934 15023544 24234451 25348397 physical association two hybrid,two hybrid ComPPI,HPRD,IntAct
MAP3K5 GSTM1 11278289 12077134 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K5 AKT1 11154276 14525934 24234451 25348397 phosphorylation reaction anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
MAP3K5 RAF1 11427728 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K5 KMT2A 25348397 N/A physical interaction ComPPI
MAP3K5 TRAF1 25348397 N/A physical interaction ComPPI
MAP3K5 TRAF3 25348397 N/A physical interaction ComPPI
MAP3K5 RB1CC1 25348397 N/A physical interaction ComPPI
MAP3K5 GNA12 25348397 N/A physical interaction ComPPI
MAP3K5 GNA13 25348397 N/A physical interaction ComPPI
MAP3K5 STUB1 16038411 17595347 20349136 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP3K5 ALK 25348397 N/A physical interaction ComPPI
MAP3K5 PRKAB2 20562859 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K5 DMD 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP3K5 USP9X 20005844 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP3K5 NEDD4 25348397 N/A physical interaction ComPPI
MAP3K5 ARRB1 19782076 24234451 25348397 physical association anti tag coimmunoprecipitation,peptide array,physical interaction ComPPI,IntAct
MAP3K5 HSPA4 25348397 N/A physical interaction ComPPI
MAP3K5 PSMC2 25348397 N/A physical interaction ComPPI
MAP3K5 PSMC1 20843792 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP3K5 PSMC4 25348397 N/A physical interaction ComPPI
MAP3K5 PSMC5 25348397 N/A physical interaction ComPPI
MAP3K5 FAS 11495919 24234451 25241761 25348397 physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
MAP3K5 JAK2 25348397 N/A physical interaction ComPPI
MAP3K5 PARK7 19293155 20213747 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MAP3K5 MBP 25348397 N/A physical interaction ComPPI
MAP3K5 DYRK1A 25348397 N/A physical interaction ComPPI
MAP3K5 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP3K5 MCRS1 22609355 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
MAP3K5 AKT2 25348397 N/A physical interaction ComPPI
MAP3K5 MAP2K3 19805025 21771788 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K5 GEMIN5 25348397 N/A physical interaction ComPPI
MAP3K5 ATAD3A 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K5 NACC1 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K5 TNFSF13B 25348397 N/A physical interaction ComPPI
MAP3K5 APP 16049941 24234451 25241761 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,proximity ligation assay ComPPI,IntAct
MAP3K5 APOBEC3G 25348397 N/A physical interaction ComPPI
MAP3K5 PGAM5 19590015 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K5 MYC 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MAP3K5 ZNF622 21771788 24234451 25348397 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,pull down,in-gel kinase assay,comigration in gel electrophoresis ComPPI,IntAct
MAP3K5 TULP3 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
YWHAQ MAP3K5 14525934 15023544 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
NEDD4L MAP3K5 25348397 N/A physical interaction ComPPI
PPP3R1 MAP3K5 14525934 16648474 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
IGF1R MAP3K5 12556535 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP3K5 MAP3K5 11336675 11920685 14525934 17937911 19805025 24234451 9743501 physical association anti tag coimmunoprecipitation,coimmunoprecipitation,cosedimentation in solution,experimental interaction detection,molecular sieving,x-ray crystallography,two hybrid HPRD,IntAct
MAPT MAP3K5 24234451 26402096 association anti bait coimmunoprecipitation IntAct
SNU13 MAP3K5 24234451 30021884 physical association cross-linking study IntAct
FBF1 MAP3K5 24234451 30021884 physical association cross-linking study IntAct
BCAS2 MAP3K5 11799062 15632076 19684577 27898060 N/A N/A OmniPath
MAP3K5 YWHAG 19935702 27898060 N/A N/A OmniPath
ARRB2 MAP3K5 11090355 11356842 18408005 19306926 19782076 27898060 N/A N/A OmniPath
MAP3K7 MAP3K5 10921914 22167179 27898060 N/A N/A OmniPath
MAP3K5 MAP3K7 10921914 22167179 27898060 N/A N/A OmniPath
MAP3K5 CDKN1A 12058028 12820963 17325029 27898060 stimulant N/A OmniPath
TRAF2 MAP3K5 10411906 10523862 10688666 12813029 15310755 16636664 17015619 17700517 17724081 18292600 18776134 19805025 27898060 9774977 stimulant N/A OmniPath
MAP3K5 TRAF2 10411906 10523862 12813029 15310755 16636664 17015619 17700517 17724081 18292600 18776134 19805025 27898060 9774977 N/A N/A OmniPath
SOCS1 MAP3K5 16407264 18776134 19287004 27898060 N/A N/A OmniPath
MAP3K5 SOCS1 16407264 18776134 19287004 27898060 N/A N/A OmniPath
MAP3K5 STRAP 19880523 21148321 27898060 N/A N/A OmniPath
TXN MAP3K5 10843682 11689443 12077134 12089063 15696199 17331951 17724081 19018770 19880523 20385180 21771788 23291592 27898060 9564042 inhibition N/A OmniPath
MAP3K5 APP 16049941 25241761 27898060 N/A N/A OmniPath
TRAF6 MAP3K5 10523862 10921914 15310755 17724081 18292600 27898060 9774977 stimulant N/A OmniPath
PIM1 MAP3K5 11154276 12697749 14500571 16532036 19749799 27898060 inhibition N/A OmniPath
PDPK1 MAP3K5 11154276 14500571 15094778 15755722 27898060 N/A N/A OmniPath
MAP3K5 PDPK1 22544756 27898060 N/A N/A OmniPath
AKT1 MAP3K5 11154276 27898060 inhibition N/A OmniPath
MAP3K5 AKT1 11154276 27898060 N/A N/A OmniPath
MAP2K4 MAP3K5 11274345 12738796 15258908 15299005 15310755 17541429 18408005 18855897 21614932 27898060 8974401 N/A N/A OmniPath
MAP3K5 MAP2K4 11274345 12738796 15258908 15299005 15310755 15911620 17541429 18408005 18855897 21614932 27898060 8974401 stimulant N/A OmniPath
GLRX MAP3K5 12244106 27898060 inhibition N/A OmniPath
MAP2K3 MAP3K5 11274345 12738796 16709866 18855897 19880523 19920149 21614932 21771788 27898060 N/A N/A OmniPath
MAP3K5 MAP2K3 11029458 11274345 12738796 16709866 18855897 19880523 19920149 21614932 21771788 27898060 stimulant N/A OmniPath
JAK1 MAP3K5 19287004 27898060 stimulant N/A OmniPath
MAPK14 MAP3K5 16709866 19749799 27898060 N/A N/A OmniPath
MAP3K5 MAPK14 10201954 10644746 10747897 11101524 12101183 12758252 12775720 14576154 15475493 15590691 15674326 15735648 15817653 15917303 16574378 16709866 16737962 16908595 16949371 16966330 16982703 17210579 17339610 17380123 17392283 17438131 17442957 17855337 18047584 18356163 18373705 18560558 19749799 19767773 19783996 20068182 20570725 20610713 20710027 20799279 20871633 21177868 21455220 21550972 21765464 21835346 23857585 23897118 23907458 24590766 24865968 25435370 25525152 25799126 27898060 7839144 stimulant N/A OmniPath
E2F1 MAP3K5 16912047 27898060 stimulant N/A OmniPath
MAP3K5 DAXX 11003656 11495919 15258908 15983381 19789334 19789335 25241761 27898060 9743501 stimulant N/A OmniPath
DAXX MAP3K5 11003656 11495919 15258908 15983381 19789334 19789335 25241761 27898060 9743501 stimulant N/A OmniPath
CDK1 MAP3K5 11920685 27898060 inhibition N/A OmniPath
RAF1 MAP3K5 11427728 27898060 inhibition N/A OmniPath
MAP3K5 RAF1 11427728 27898060 N/A N/A OmniPath
FAS MAP3K5 11495919 25241761 27898060 stimulant N/A OmniPath
PPP5C MAP3K5 11689443 17456047 27898060 inhibition N/A OmniPath
MAP3K5 MAP2K6 11460167 11689443 12820963 15866172 20213747 27898060 8622669 8974401 stimulant N/A OmniPath
BIRC2 MAP3K5 17220297 27898060 N/A N/A OmniPath
MAPK1 MAP3K5 16709866 27898060 stimulant N/A OmniPath
PTPN11 MAP3K5 19287004 27898060 stimulant N/A OmniPath
MAP3K5 PTPN11 19287004 27898060 N/A N/A OmniPath
MAP3K5 BIRC5 16540654 27898060 N/A N/A OmniPath
AKT2 MAP3K5 11154276 12697749 27898060 inhibition N/A OmniPath
MAP3K5 MAP2K7 11959862 17110930 19920149 27898060 stimulant N/A OmniPath
JAK2 MAP3K5 19287004 27898060 inhibition N/A OmniPath
MAP3K5 MAPK8 15242986 15247305 16760468 21856198 26147002 26375285 27898060 9312068 stimulant N/A OmniPath
YWHAQ MAP3K5 15023544 19880523 27898060 inhibition N/A OmniPath
MAP3K5 YWHAQ 15023544 19880523 27898060 N/A N/A OmniPath
MAP3K5 GEMIN5 17541429 27898060 N/A N/A OmniPath
DAB2IP MAP3K5 12813029 15310755 17389591 19903888 27858941 27898060 stimulant N/A OmniPath
MAP3K5 DAB2IP 12813029 15310755 17389591 19903888 27898060 N/A N/A OmniPath
TPD52L1 MAP3K5 14761963 27898060 N/A N/A OmniPath
MAP3K5 DOK1 10688886 10852966 11042170 12087092 15574499 27898060 N/A N/A OmniPath
MAP3K6 MAP3K5 11689443 17210579 19935702 25852190 27898060 9875215 stimulant N/A OmniPath
MAP3K5 MAP3K6 11689443 17210579 19935702 25852190 27898060 9875215 N/A N/A OmniPath
MAP3K5 GSPT1 17700517 27898060 N/A N/A OmniPath
PGAM5 MAP3K5 19590015 27898060 N/A N/A OmniPath
HSPA2 MAP3K5 12391142 27898060 inhibition N/A OmniPath
SLK MAP3K5 16316999 27898060 stimulant N/A OmniPath
MAP3K5 ZNF622 21771788 27898060 stimulant N/A OmniPath
PPM1L MAP3K5 17456047 27898060 inhibition N/A OmniPath
MAP3K5 TNNT2 12819028 27898060 stimulant N/A OmniPath

Visualization










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