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GENE：MAPK7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAPK7
FullNmae mitogen-activated protein kinase 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6880
EnsembleID ENSG00000166484
Uniprot Q13164

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAPK7 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAPK7 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAPK7 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAPK7 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MAPK7 GO:0000165,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0007049,GO:0007165,GO:0016310,GO:0016605,GO:0019933,GO:0030154,GO:0033173,GO:0034115,GO:0035556,GO:0036003,GO:0045765,GO:0045944,GO:0050728,GO:0051019,GO:0051247,GO:0051344,GO:0060761,GO:0070301,GO:0070885,GO:0071363,GO:0071499,GO:0071499,GO:0071560,GO:0106310,GO:1902176,GO:2000352,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAPK7 hsa:5598 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAPK7 hsa:5598 path:hsa04540 Gap junction - Homo sapiens (human)
MAPK7 hsa:5598 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
MAPK7 hsa:5598 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
MAPK7 hsa:5598 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)
MAPK7 hsa:5598 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
MAPK7 hsa:5598 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
MAPK7 hsa:5598 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APP MAPK7 21832049 23180781 physical association protein array InnateDB
MAPK7 MEF2C 18988627 20936779 21071413 23331499 9384584 9753748 stimulation N/A SignaLink,SignaLink
MAPK7 MEF2A 10849446 18988627 23331499 9753748 9858528 stimulation N/A SignaLink,SignaLink
MAP2K5 MAPK7 11242034 23331499 stimulation N/A SignaLink,SignaLink
MAPK7 RPS6KA1 16626623 23331499 stimulation N/A SignaLink,SignaLink

Source Target Pmid Interactiontype Methods Database
GJA1 MAPK7 20005715 interaction type N/A PSP
YWHAB MAPK7 20005715 interaction type N/A PSP
YWHAE MAPK7 20005715 interaction type N/A PSP
YWHAB MAPK7 14679215 14679215 20005715 20005715 21071413 N/A N/A SignaLink
GJA1 MAPK7 12637502 20005715 20005715 21071413 N/A N/A SignaLink
YWHAE MAPK7 14679215 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 MAPK7 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A MAPK7 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 MAPK7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MAPK7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAPK7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MEF2A MAPK7 18073218 trascriptional regulation,stimulation inferred by curator TFlink
MEF2C MAPK7 11158308 trascriptional regulation,stimulation inferred by curator TFlink
MYC MAPK7 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000008A99 MAPK7 N/A 15504739 16966691 16969504 17504027 17892514 19157460 19464056 19843160 19855844 23276710 \N rna interference,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000008A99 MAPK7 15504739 16966691 16969504 17504027 17892514 19157460 19464056 19843160 19855844 21901135 22374674 22743998 22942087 23276710 25416803 25477374 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS00000EC1BE MAPK7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C3AC1 MAPK7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001EFEC1 MAPK7 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB MAPK7 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002A71AD MAPK7 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 MAPK7 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 MAPK7 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD MAPK7 22012620 25416803 27545608 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS00002C02E4 MAPK7 22012620 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP2K5 MAPK7 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK3 MAPK7 22135298 phosphorylation N/A PhosphoSite
MAPK1 MAPK7 22135298 phosphorylation N/A PhosphoSite
RPS6KA1 MAPK7 22135298 phosphorylation N/A PhosphoSite
MAPK7 MAPK7 22135298 phosphorylation N/A PhosphoSite
MAPK7 FOS 22135298 phosphorylation N/A PhosphoSite
MAPK7 MEF2A 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK7 DLG1 22135298 phosphorylation N/A PhosphoSite
MAPK7 MAP2K5 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK7 PML 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK7 SGK1 22135298 phosphorylation N/A PhosphoSite
MAPK7 ETS1 22135298 phosphorylation N/A PhosphoSite
RAF1 MAPK7 25361965 interaction type N/A PTMCode2
MAPK7 RAF1 25361965 interaction type N/A PTMCode2
MEF2A MAPK7 25361965 interaction type N/A PTMCode2
MAPK7 MEF2C 25361965 interaction type N/A PTMCode2
MEF2C MAPK7 25361965 interaction type N/A PTMCode2
MAPK7 RXRA 25361965 interaction type N/A PTMCode2
RXRA MAPK7 25361965 interaction type N/A PTMCode2
PML MAPK7 25361965 interaction type N/A PTMCode2
GJA1 MAPK7 25361965 interaction type N/A PTMCode2
MAPK7 GJA1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GPSM3 MAPK7 25348397 N/A physical interaction ComPPI
ZKSCAN1 MAPK7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
BAG3 MAPK7 25348397 N/A physical interaction ComPPI
RARA MAPK7 25348397 N/A anti bait coimmunoprecipitation ComPPI
TUBB MAPK7 25348397 N/A physical interaction ComPPI
ACTB MAPK7 25348397 N/A physical interaction ComPPI
YWHAG MAPK7 25348397 N/A physical interaction ComPPI
HSP90AB1 MAPK7 22939624 24234451 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
VBP1 MAPK7 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MACIR MAPK7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PFDN4 MAPK7 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
EGLN3 MAPK7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKCA MAPK7 25348397 N/A physical interaction ComPPI
NFE2L2 MAPK7 25348397 N/A physical interaction ComPPI
JUP MAPK7 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAB MAPK7 14525934 14679215 24234451 25348397 association two hybrid,coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
ACTN4 MAPK7 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
GAPDH MAPK7 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAZ MAPK7 25348397 N/A physical interaction ComPPI
HSP90AA1 MAPK7 25348397 N/A physical interaction ComPPI
NTRK1 MAPK7 25348397 N/A physical interaction ComPPI
NR1I2 MAPK7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
HSPA5 MAPK7 25348397 N/A physical interaction ComPPI
HSP90B1 MAPK7 25348397 N/A physical interaction ComPPI
MYC MAPK7 14525934 25348397 9461566 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPRR MAPK7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PRKCZ MAPK7 25348397 N/A physical interaction ComPPI
FSCN1 MAPK7 25348397 N/A physical interaction ComPPI
MAP2K5 MAPK7 24234451 25348397 7759517 physical association two hybrid,pull down,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,IntAct
PKM MAPK7 25348397 N/A physical interaction ComPPI
XPO1 MAPK7 25348397 N/A physical interaction ComPPI
MAPK7 MEF2A 10849446 14525934 25348397 9753748 9858528 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAPK7 MEF2C 14525934 20936779 24234451 25348397 9384584 9753748 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,HPRD,IntAct
MAPK7 MEF2D 10849446 14525934 25348397 9753748 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK7 SGK1 11254654 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
MAPK7 GJA1 12637502 14525934 25348397 8631994 9535905 9535909 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK7 ELK4 10473620 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAPK7 ETS1 11948414 12048211 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK7 RAF1 10531364 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK7 YWHAE 25348397 N/A physical interaction ComPPI
MAPK7 GOLGB1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAPK7 FOS 25348397 N/A physical interaction ComPPI
MAPK7 APP 25348397 N/A physical interaction ComPPI
MAPK7 PML 20832753 24234451 25348397 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,physical interaction,fluorescence microscopy,protein kinase assay ComPPI,IntAct
MAPK7 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAPK7 GANAB 25348397 N/A physical interaction ComPPI
MAPK7 HSPA4 25348397 N/A physical interaction ComPPI
MAPK7 ATP5F1A 25348397 N/A physical interaction ComPPI
MAPK7 PPP3CA 25348397 N/A physical interaction ComPPI
MAPK7 LDHC 25348397 N/A physical interaction ComPPI
MAPK7 MYLK2 25348397 N/A physical interaction ComPPI
MAPK7 YWHAH 25348397 N/A physical interaction ComPPI
MAPK7 CDC37 24234451 25036637 25348397 physical association physical interaction,luminescence based mammalian interactome mapping ComPPI,IntAct
MAPK7 FGF21 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK7 SH2D2A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK7 ZBED6CL 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK7 PFDN1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK7 PFDN2 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK7 PFDN6 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK7 PFDN5 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK7 DSC1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK7 DSG1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MAPK7 TP53 25348397 N/A physical interaction ComPPI
MAPK7 MAP3K2 25348397 N/A physical interaction ComPPI
MAPK7 UBE2C 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK7 DOT1L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK7 CCDC6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK7 RXRA 12048211 14525934 N/A experimental interaction detection HPRD
MAPK7 GJA1 12637502 19664994 27898060 8631994 9535905 9535909 inhibition,stimulant N/A OmniPath
MAPK7 RPS6KA1 16626623 27898060 stimulant N/A OmniPath
APP MAPK7 21244100 21832049 27898060 N/A N/A OmniPath
MAPK7 APP 21244100 21832049 27898060 N/A N/A OmniPath
MAPK7 PML 20832753 22869143 27898060 inhibition N/A OmniPath
MAPK7 NR4A1 18429814 27898060 stimulant N/A OmniPath
MAPK7 RXRA 12048211 27898060 N/A N/A OmniPath
MAPK7 MEF2A 10330143 10849446 12586839 17785444 27898060 9753748 9858528 stimulant N/A OmniPath
MAPK1 MAPK7 11739740 27898060 N/A N/A OmniPath
MAPK7 SGK1 10191262 11254654 18691976 19369195 27898060 stimulant N/A OmniPath
MAP2K5 MAPK7 11242034 11739740 11782488 12628002 12912994 22267842 23612709 24975362 27898060 7646528 7759517 stimulant N/A OmniPath
MAPK7 MAP2K5 11739740 11782488 12628002 12912994 22267842 23612709 24975362 27898060 7646528 7759517 stimulant N/A OmniPath
MAPK7 ETS1 11948414 12048211 20361728 20435626 25885538 27898060 8552081 8761310 stimulant N/A OmniPath
MAPK7 MEF2D 10849446 16964243 18669648 18691976 18767875 20068231 27898060 9753748 stimulant N/A OmniPath
MAPK7 NFATC4 11997522 18347059 27898060 N/A N/A OmniPath
MAPK7 PTPRR 12042304 27898060 stimulant N/A OmniPath
PTPRR MAPK7 12042304 27898060 N/A N/A OmniPath
MAPK7 MEF2C 20936779 27898060 9069290 9384584 9753748 stimulant N/A OmniPath

Visualization










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