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GENE：MAPK8IP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAPK8IP2
FullNmae mitogen-activated protein kinase 8 interacting protein 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6883
EnsembleID ENSG00000008735
Uniprot Q13387

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAPK8IP2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAPK8IP2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAPK8IP2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MAPK8IP2 GO:0001540,GO:0001662,GO:0005078,GO:0005078,GO:0005078,GO:0005198,GO:0005515,GO:0005737,GO:0005737,GO:0007172,GO:0007254,GO:0007617,GO:0008432,GO:0010469,GO:0014069,GO:0019894,GO:0019901,GO:0032874,GO:0032991,GO:0035176,GO:0043025,GO:0044877,GO:0046328,GO:0046958,GO:0048813,GO:0051966,GO:0060079,GO:2000310,GO:2000311,GO:2001234

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAPK8IP2 hsa:23542 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPK8IP2 MAP2K7 10756100 23180781 physical association gst pull down InnateDB
MAPK8IP2 MAPK14 12024021 23331499 stimulation N/A SignaLink,SignaLink
MAPK8IP2 MAPK8 10490659 10756100 23331499 stimulation N/A SignaLink
MAPK8IP2 MAPK13 12244047 23331499 stimulation N/A SignaLink
DUSP16 MAPK8IP2 12524447 23331499 stimulation N/A SignaLink
MAPK8IP2 MAPK10 15767678 23331499 stimulation N/A SignaLink
MAPK8IP2 MAPK9 10490659 15767678 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
MAPK8IP2 MAP2K7 10490659 20005715 21071413 interaction type N/A PSP,SignaLink
MAPK8IP2 MAPK13 20005715 interaction type N/A PSP,SignaLink
MAPK8IP2 MAPK8 20005715 interaction type N/A PSP
MAPK8IP2 MAPK9 20005715 interaction type N/A PSP
MAPK8IP2 MAP2K3 20005715 interaction type N/A PSP,SignaLink
MAPK8IP2 MAPK10 20005715 interaction type N/A PSP,SignaLink
MAPK8IP2 MAP3K10 20005715 interaction type N/A PSP
MAPK8IP2 MAP3K12 20005715 interaction type N/A PSP
MAPK8IP2 MAP3K11 10490659 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
MAPK8IP2 DUSP16 12524447 18988627 20005715 interaction type N/A PSP,SignaLink
MAPK8IP2 MAP3K10 10490659 10490659 10490659 18988627 20005715 20005715 21071413 N/A N/A SignaLink
MAPK8IP2 MAP3K12 10490659 10490659 20005715 20005715 21071413 N/A N/A SignaLink
MAPK8IP2 MAPK8 20005715 20005715 N/A N/A SignaLink
MAPK8IP2 MAPK9 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
FOXP3 MAPK8IP2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF MAPK8IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAPK8IP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001C3AC1 MAPK8IP2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002E728C MAPK8IP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000419B5A MAPK8IP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000033B548 MAPK8IP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 MAPK8IP2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 MAPK8IP2 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
IL1B MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 IL1B 25361965 interaction type N/A PTMCode2
TIAM1 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 TIAM1 25361965 interaction type N/A PTMCode2
MAPK13 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAPK13 25361965 interaction type N/A PTMCode2
MAP3K10 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAP3K10 25361965 interaction type N/A PTMCode2
MAPK8 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAPK8 25361965 interaction type N/A PTMCode2
MAPK8IP1 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAPK8IP1 25361965 interaction type N/A PTMCode2
LRP8 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 LRP8 25361965 interaction type N/A PTMCode2
APP MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 APP 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAP2K3 25361965 interaction type N/A PTMCode2
MAP2K3 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAP2K7 25361965 interaction type N/A PTMCode2
MAP2K7 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 FGF12 25361965 interaction type N/A PTMCode2
FGF12 MAPK8IP2 25361965 interaction type N/A PTMCode2
LRP2 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 LRP2 25361965 interaction type N/A PTMCode2
MAP3K11 MAPK8IP2 25361965 interaction type N/A PTMCode2
MAPK8IP2 MAP3K11 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SPSB3 MAPK8IP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK9 MAPK8IP2 10490659 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SLPI MAPK8IP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CFL1 MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
SPINK2 MAPK8IP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
VCP MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZNF670 MAPK8IP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RYBP MAPK8IP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TP53BP2 MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ERBB2 MAPK8IP2 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
EZH2 MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TIAM1 MAPK8IP2 12024021 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK8 MAPK8IP2 10490659 10756100 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
UNC119 MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RBM4 MAPK8IP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RBX1 MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
LSM8 MAPK8IP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NUMB MAPK8IP2 25348397 N/A physical interaction ComPPI
MAP3K10 MAPK8IP2 10490659 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSPA1A MAPK8IP2 25348397 N/A physical interaction ComPPI
HSPA1B MAPK8IP2 25348397 N/A physical interaction ComPPI
TARBP2 MAPK8IP2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP3 MAPK8IP2 10629060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LRP1 MAPK8IP2 10827173 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
LRP8 MAPK8IP2 25348397 N/A physical interaction ComPPI
MAPK13 MAPK8IP2 25348397 N/A physical interaction ComPPI
DUSP16 MAPK8IP2 12524447 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FSCN1 MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP1 MAPK8IP2 10490659 10629060 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAPK8IP2 FGF12 11378392 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MAPK8IP2 MAP2K3 25348397 N/A physical interaction,in vivo ComPPI
MAPK8IP2 MAP2K7 25348397 N/A physical interaction,in vitro,in vivo ComPPI
MAPK8IP2 MAP3K11 10490659 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAPK8IP2 PRSS23 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAPK8IP2 KLC1 12893827 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
MAPK8IP2 MAP3K12 25348397 N/A physical interaction,in vivo ComPPI
MAPK8IP2 LRP2 10827173 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
MAPK8IP2 FGF13 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 MAPK10 25348397 N/A physical interaction ComPPI
MAPK8IP2 AFG3L2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 KIFC2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 ZNF784 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 ASRGL1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 SYNE2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 NDUFS6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 RAI1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 BBS10 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 YY1AP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 SMARCB1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 VPS33B 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 CHN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 MAGED4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 ERG28 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 GBP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 CRMP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 PLXNA3 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 MASP1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 ITSN1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 SMS 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 RPS6KB2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 VRK2 25348397 N/A physical interaction ComPPI
MAPK8IP2 EGFR 16273093 24234451 24658140 25348397 physical association protein array,ubiquitin reconstruction,physical interaction ComPPI,IntAct
MAPK8IP2 APP 12893827 14525934 25348397 N/A physical interaction,two hybrid ComPPI,HPRD
MAPK8IP2 ADRB2 25348397 N/A physical interaction ComPPI
MAPK8IP2 FBXW11 25348397 N/A physical interaction ComPPI
MAPK8IP2 C22ORF39 25348397 N/A physical interaction ComPPI
MAPK8IP2 C8ORF33 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
MAPK8IP2 IGIP 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
MAPK8IP2 TMEM128 25348397 N/A physical interaction ComPPI
MAPK8IP2 ANGPT1 25348397 N/A physical interaction ComPPI
MAPK8IP2 UBD 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
MAPK8IP2 C1QTNF3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 CTNNBL1 25348397 N/A physical interaction ComPPI
MAPK8IP2 DUSP18 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 ING4 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 MSRB3 25348397 N/A physical interaction ComPPI
MAPK8IP2 SCLT1 25348397 N/A physical interaction ComPPI
MAPK8IP2 SH2D1B 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 SLC39A13 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 USP46 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 POLR1H 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 ANAPC10 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 CRP 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 GALNT3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 HLA-C 25348397 N/A physical interaction ComPPI
MAPK8IP2 LEFTY2 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 MNDA 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 MRE11 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 RABGAP1L 25348397 N/A physical interaction ComPPI
MAPK8IP2 RABGAP1L 25348397 N/A physical interaction ComPPI
MAPK8IP2 SRP19 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAPK8IP2 RAPGEF5 25348397 N/A physical interaction ComPPI
MAPK8IP2 TULP2 25348397 N/A physical interaction ComPPI
MAPK8IP2 LRRK2 20173330 24234451 25348397 physical association coimmunoprecipitation ComPPI,IntAct
ZNF593 MAPK8IP2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK8IP2 MAPK8IP2 11378392 12244047 14525934 N/A experimental interaction detection,two hybrid HPRD
MAPK8IP2 MAPK10 15767678 27898060 stimulant N/A OmniPath
MAPK8IP2 MAPK9 10490659 1576768 27898060 stimulant N/A OmniPath
MAPK8IP2 MAPK13 11378392 12244047 27898060 stimulant N/A OmniPath
MAPK8IP2 MAPK14 12024021 27898060 stimulant N/A OmniPath
MAPK8IP2 MAPK8IP1 10490659 10629060 27898060 stimulant N/A OmniPath
MAP2K7 MAPK8IP2 10490659 10756100 27898060 N/A N/A OmniPath
MAPK8IP2 MAP2K7 10490659 10756100 27898060 9733513 stimulant N/A OmniPath
MAPK8IP2 MAPK8 10490659 107561 10756100 27898060 stimulant N/A OmniPath
DUSP16 MAPK8IP2 12524447 27898060 stimulant N/A OmniPath

Visualization










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