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GENE：MELK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MELK
FullNmae maternal embryonic leucine zipper kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16870
EnsembleID ENSG00000165304
Uniprot Q14680

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MELK mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MELK apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MELK apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MELK GO:0000086,GO:0004674,GO:0004674,GO:0004715,GO:0004715,GO:0005509,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0005938,GO:0006468,GO:0006915,GO:0008283,GO:0008289,GO:0008631,GO:0016020,GO:0030097,GO:0035556,GO:0043065,GO:0046777,GO:0061351,GO:0106310

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR MELK 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MELK 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MELK 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MELK 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MELK 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MELK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MELK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MELK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MELK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MELK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MELK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MELK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MELK 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 MELK 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000065FDF MELK 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000BB229 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021202F MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000411752 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000568FF8 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D MELK 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 MELK 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
STK11 MELK 22135298 phosphorylation N/A PhosphoSite
MELK CDC25B 22135298 phosphorylation N/A PhosphoSite
MELK EIF4B 22135298 phosphorylation N/A PhosphoSite
LMNB1 MELK 25361965 interaction type N/A PTMCode2
MELK LMNB1 25361965 interaction type N/A PTMCode2
MELK BCL2L14 25361965 interaction type N/A PTMCode2
BCL2L14 MELK 25361965 interaction type N/A PTMCode2
MELK ZNF622 25361965 interaction type N/A PTMCode2
ZNF622 MELK 25361965 interaction type N/A PTMCode2
MELK PPP1R8 25361965 interaction type N/A PTMCode2
PPP1R8 MELK 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC5L MELK 14525934 16216881 20467437 24234451 25348397 association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,IntAct
FAM110A MELK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
STK16 MELK 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
FAM53C MELK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CBY1 MELK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PPP1R8 MELK 14525934 16216881 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
SF3B1 MELK 14525934 16216881 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HDAC4 MELK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RTKN MELK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GIGYF1 MELK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RHPN1 MELK 25348397 N/A physical interaction ComPPI
PLAUR MELK 25348397 N/A physical interaction ComPPI
MAGI1 MELK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PRG2 MELK 25348397 N/A physical interaction ComPPI
PROZ MELK 25348397 N/A physical interaction ComPPI
EIF2S1 MELK 14525934 16216881 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RAB3IP MELK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK MBP 14525934 16216881 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MELK H1-5 14525934 16216881 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MELK LMNB1 14525934 16216881 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MELK ZNF622 11802789 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MELK CDC25B 24234451 25348397 physical association physical interaction,in vitro,in vivo,inference by socio-affinity scoring ComPPI,IntAct
MELK BABAM1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MELK SPACA1 25348397 N/A physical interaction ComPPI
MELK MLST8 25348397 N/A physical interaction ComPPI
MELK CBWD1 25348397 N/A physical interaction ComPPI
MELK PCDHGA5 25348397 N/A physical interaction ComPPI
MELK IL13RA2 25348397 N/A physical interaction ComPPI
MELK HAVCR2 25348397 N/A physical interaction ComPPI
MELK CD79B 25348397 N/A physical interaction ComPPI
MELK P4HA2 25348397 N/A physical interaction ComPPI
MELK SNX21 25348397 N/A physical interaction ComPPI
MELK KCTD3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK KIF13B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK ZBTB21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK KSR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK LRFN1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK DENND1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK SH3PXD2A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK SRGAP2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK EIF4E2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK SIPA1L1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK LIMA1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK TESK2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK DCLK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK ZNF638 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK MAST3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK PPM1H 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK SRSF12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK SYDE1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK DENND4C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK CGN 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK AGAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK CDK16 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK FAM110B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK USP21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK MAPKAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK ANKRD34A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MELK BCL2L14 17280616 24234451 25348397 27898060 phosphorylation reaction,physical association anti tag coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct,OmniPath
MKI67 MELK 24234451 26949251 association anti tag coimmunoprecipitation IntAct
H2BC21 MELK 24234451 30021884 physical association cross-linking study IntAct
MELK CDC25B 11333986 12400006 15629715 15908796 21558810 26140595 27898060 inhibition,stimulant N/A OmniPath
STK11 MELK 14699119 14976552 16216881 27898060 stimulant N/A OmniPath
MELK PDPK1 22544756 27898060 N/A N/A OmniPath

Visualization










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