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GENE：MIF

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MIF
FullNmae macrophage migration inhibitory factor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7097
EnsembleID ENSG00000240972
Uniprot P14174

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MIF parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MIF parthanatos 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
MIF apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MIF apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MIF GO:0001516,GO:0001819,GO:0002020,GO:0002906,GO:0004167,GO:0005125,GO:0005125,GO:0005126,GO:0005126,GO:0005515,GO:0005576,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006954,GO:0007166,GO:0008284,GO:0009986,GO:0010629,GO:0010739,GO:0010760,GO:0019752,GO:0030330,GO:0030336,GO:0030890,GO:0031666,GO:0031982,GO:0032760,GO:0033033,GO:0033138,GO:0034774,GO:0042056,GO:0042327,GO:0042802,GO:0043030,GO:0043066,GO:0043518,GO:0045087,GO:0048146,GO:0050178,GO:0050178,GO:0050731,GO:0050918,GO:0051248,GO:0061078,GO:0061081,GO:0070062,GO:0070207,GO:0070374,GO:0070374,GO:0090238,GO:0090398,GO:1902166,GO:1904813,GO:2000343,GO:2000773

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MIF hsa:4282 path:hsa00350 Tyrosine metabolism - Homo sapiens (human)
MIF hsa:4282 path:hsa00360 Phenylalanine metabolism - Homo sapiens (human)
MIF hsa:4282 path:hsa01100 Metabolic pathways - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MIF CD74 10878343 12782713 12803886 16181339 16283355 18490733 20861157 23390297 26192618 8195715 9637476 association N/A ACSN
MIF BCL2L11 18677096 26192618 association N/A ACSN
MIF CD80 10878343 12782713 12803886 16283355 18490733 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
MIF CD86 10878343 12782713 12803886 16283355 18490733 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
MIF IL10 10878343 12782713 12803886 15749884 16283355 16713974 17404308 18490733 20547845 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
MIF NOS2 10878343 11399519 11875494 12782713 12803886 15644117 16127449 16283355 17260466 17689680 18490733 20861157 23390297 26192618 6357187 8195715 8871614 9637476 interaction type N/A ACSN
MIF MMP9 10878343 11875494 12782713 12803886 16283355 18490733 20861157 22461508 23390297 26192618 8195715 9637476 interaction type N/A ACSN
MIF VEGFA 10878343 12782713 12803886 16283355 18490733 20861157 21372296 21765015 22461508 23390297 26192618 8195715 9637476 interaction type N/A ACSN
MIF SPI1 10878343 12782713 12803886 16283355 18490733 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
MIF IRF5 10878343 12782713 12803886 16283355 18490733 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
MIF PTGS2 10878343 12782713 12803886 16283355 18490733 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
HIF1A MIF 10804084 16110315 16127144 17533374 20427344 20535745 20855962 21051947 21765015 22006996 22850421 22988108 24006507 25043024 25103413 25732824 26192618 interaction type N/A ACSN
TLR4 MIF 11672593 11964313 12032143 12803886 12811837 16267105 26192618 interaction type N/A ACSN
TNF MIF 10754326 10878343 10925299 10952726 11112697 11438547 11875494 12646658 12782713 12803886 12811837 12907458 1431106 14607933 14625680 14660645 15099563 15465827 15644117 15699106 16283355 16713974 16878026 17404308 17485448 17916596 18490733 18633355 19411070 20038811 20184663 20435894 20861157 21133840 21411734 21826665 22595692 22955274 23170255 23390297 23430059 23508573 23510023 23567181 23769623 24092389 24378531 26192618 26201938 7594497 8195715 8910423 9637476 interaction type N/A ACSN
IFNG MIF 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26192618 26755705 2965306 6425450 9834059 9864217 interaction type N/A ACSN
MIF PRF1 10878343 12782713 12803886 16283355 18490733 20861157 23390297 26192618 8195715 9637476 interaction type N/A ACSN
COPS5 MIF 11089976 23180781 physical association pull down InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 MIF 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A MIF 18971253 19828020 20727156 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SP1 MIF 18034423 21087445 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
CEBPA MIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MIF 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GPIHBP1 MIF 20383199 trascriptional regulation,stimulation inferred by curator TFlink
HBP1 MIF 20383199 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 MIF 18710704 trascriptional regulation,stimulation inferred by curator TFlink
RELA MIF 18710704 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 MIF 18034423 trascriptional regulation,stimulation inferred by curator TFlink
AR MIF N/A trascriptional regulation,stimulation inferred by curator TFlink
RARA MIF N/A trascriptional regulation,stimulation inferred by curator TFlink
RARB MIF N/A trascriptional regulation,stimulation inferred by curator TFlink
RARG MIF N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 MIF N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002E857A MIF 19318487 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00002E857A MIF 19318487 24138931 25416803 26884830 28086136 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EC1BE MIF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004E008F MIF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD MIF 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001EFBE3 MIF 25416803 27569893 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000100748 MIF 25416803 28465246 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MIF TP53 25361965 interaction type N/A PTMCode2
TP53 MIF 25361965 interaction type N/A PTMCode2
MIF COPS6 25361965 interaction type N/A PTMCode2
COPS6 MIF 25361965 interaction type N/A PTMCode2
MIF BCL2L11 25361965 interaction type N/A PTMCode2
BCL2L11 MIF 25361965 interaction type N/A PTMCode2
MIF S100A9 25361965 interaction type N/A PTMCode2
S100A9 MIF 25361965 interaction type N/A PTMCode2
CD74 MIF 25361965 interaction type N/A PTMCode2
MIF CD74 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
ZNF408 MIF 14525934 15231747 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
CDC73 MIF 25348397 N/A physical interaction ComPPI
BCL2L11 MIF 25348397 N/A two hybrid ComPPI
EIF1B MIF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LDHB MIF 25348397 N/A physical interaction ComPPI
LDHA MIF 25348397 N/A physical interaction ComPPI
PCBP1 MIF 25348397 N/A physical interaction ComPPI
TRAF6 MIF 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF GORASP2 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MIF COPS6 14525934 15757663 24234451 25348397 physical association coimmunoprecipitation,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
MIF STRN4 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MIF NME1 14525934 18815136 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MIF CD74 12782713 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MIF COPS5 11089976 14525934 15757663 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,mass spectrometry studies of complexes,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
MIF BNIPL 12681488 14525934 21988832 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
MIF FIBP 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MIF VHL 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MIF STUB1 25348397 N/A physical interaction ComPPI
MIF HSP90AA1 25348397 N/A physical interaction ComPPI
MIF HSP90AA2P 25348397 N/A physical interaction ComPPI
MIF CDK2 25348397 N/A physical interaction ComPPI
MIF TP53 14525934 18815136 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
MIF IGBP1 25348397 N/A physical interaction ComPPI
MIF CLNS1A 25348397 N/A physical interaction ComPPI
MIF VCAM1 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
MIF FN1 25348397 N/A physical interaction ComPPI
MIF ITGA4 25348397 N/A physical interaction ComPPI
MIF BEX3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MIF UPF2 25348397 N/A physical interaction ComPPI
MIF ASB15 25348397 N/A physical interaction ComPPI
MIF NTAQ1 25348397 N/A physical interaction ComPPI
MIF CUL7 25348397 N/A physical interaction ComPPI
MIF AKR1C2 25348397 N/A physical interaction ComPPI
MIF ANXA11 25348397 N/A physical interaction ComPPI
MIF CAPG 25348397 N/A physical interaction ComPPI
MIF COX17 25348397 N/A physical interaction ComPPI
MIF CRIP1 25348397 N/A physical interaction ComPPI
MIF DSTN 25348397 N/A physical interaction ComPPI
MIF ENO1 25348397 N/A physical interaction ComPPI
MIF FSCN1 25348397 N/A physical interaction ComPPI
MIF GBE1 25348397 N/A physical interaction ComPPI
MIF HINT1 25348397 N/A physical interaction ComPPI
MIF LAP3 25348397 N/A physical interaction ComPPI
MIF MPI 25348397 N/A physical interaction ComPPI
MIF NANP 25348397 N/A physical interaction ComPPI
MIF PABPC1 25348397 N/A physical interaction ComPPI
MIF PAICS 25348397 N/A physical interaction ComPPI
MIF PARK7 25348397 N/A physical interaction ComPPI
MIF PCMT1 25348397 N/A physical interaction ComPPI
MIF PDCD6 25348397 N/A physical interaction ComPPI
MIF PDCD6IP 25348397 N/A physical interaction ComPPI
MIF PIR 25348397 N/A physical interaction ComPPI
MIF SPR 25348397 N/A physical interaction ComPPI
MIF TIMM13 25348397 N/A physical interaction ComPPI
MIF TKT 25348397 N/A physical interaction ComPPI
MIF YKT6 25348397 N/A physical interaction ComPPI
MIF UFM1 25348397 N/A physical interaction ComPPI
MIF CEP290 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MIF MKNK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MIF VPS26A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MIF MCM2 25348397 N/A physical interaction ComPPI
MIF EGFR 24234451 25348397 26280537 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MIF DLD 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MIF SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
MIF KEAP1 25348397 N/A physical interaction ComPPI
MIF EPB41 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF PINX1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF TNFRSF10D 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF FBXO11 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF FTSJ1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF ATG5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF HLA-B 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF DSTYK 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF CFLAR 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF TNFRSF14 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF MPG 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF PRKAB1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF ILK 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MIF MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MIF MAP1LC3B 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MIF GABARAPL2 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MIF GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MIF GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MIF MIF 10353846 11170644 11997397 14525934 20534506 24234451 8610159 physical association experimental interaction detection,nuclear magnetic resonance,x-ray crystallography,two hybrid array,two hybrid prey pooling approach HPRD,IntAct
MIF CD74 12782713 27898060 stimulant N/A OmniPath

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