Gene Information gene info

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GENE：MADD

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MADD
FullNmae MAP kinase activating death domain
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6766
EnsembleID ENSG00000110514
Uniprot Q8WXG6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MADD necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MADD apoptosis 24038283 Here, we report that MADD can act as a pro-apoptotic factor to initiate TRAIL-induced apoptosis when its phosphorylation is attenuated by PTEN. retulator signature
MADD apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
MADD cuproptosis 36505872 A total of 44 cuproptosis-related genes were extracted from known literature. cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
MADD GO:0005085,GO:0005085,GO:0005085,GO:0005085,GO:0005123,GO:0005515,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0007166,GO:0016020,GO:0030295,GO:0030424,GO:0032483,GO:0032483,GO:0042981,GO:0042981,GO:0043410,GO:0051726,GO:0097194,GO:1902041,GO:2001236

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MADD 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MADD 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MADD 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
EGR1 MADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MADD 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC MADD N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 MADD 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS0000204177 MADD 24374217 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
YWHAZ MADD 16959763 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NTRK1 MADD 25348397 N/A physical interaction ComPPI
TNFRSF1A MADD 14525934 25348397 9115275 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRK5 MADD 25348397 N/A physical interaction ComPPI
XPO1 MADD 25348397 N/A physical interaction ComPPI
ALOX5 MADD 25348397 N/A physical interaction ComPPI
MADD PIDD1 10825539 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MADD TNFRSF10A 14525934 15208670 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MADD TNFRSF10B 14525934 15208670 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MADD PTPRN 14525934 16273344 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD,IntAct
MADD POT1 21044950 24234451 25348397 physical association pull down,physical interaction,bimolecular fluorescence complementation ComPPI,IntAct
MADD SHMT2 25348397 N/A physical interaction ComPPI
MADD SOCS6 25348397 N/A physical interaction ComPPI
MADD PRMT6 25348397 N/A physical interaction ComPPI
MADD HLA-E 25348397 N/A physical interaction ComPPI
MADD RB1CC1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MADD BBS7 25348397 N/A physical interaction ComPPI
MADD WNK1 20936779 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MADD RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
MADD PTPRB 24234451 30021884 physical association cross-linking study IntAct
THRAP3 MADD 24234451 30021884 physical association cross-linking study IntAct
MADD NUP37 24234451 30021884 physical association cross-linking study IntAct
PIDD1 MADD 10825539 27898060 N/A N/A OmniPath

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