GENE:MKNK2
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | MKNK2 |
FullNmae | MAPK interacting serine/threonine kinase 2 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:7111 |
EnsembleID | ENSG00000099875 |
Uniprot | Q9HBH9 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
MKNK2 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MKNK2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MKNK2 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MKNK2 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
MKNK2 | GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006417,GO:0006468,GO:0007166,GO:0009931,GO:0016604,GO:0016605,GO:0018105,GO:0030097,GO:0035556,GO:0035556,GO:0046777,GO:0046872,GO:0071243,GO:0097192,GO:0106310 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
MKNK2 | hsa:2872 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
MKNK2 | hsa:2872 | path:hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
MKNK2 | hsa:2872 | path:hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
MKNK2 | EIF4E | 11463832 12897141 23180781 23331499 9155017 | phosphorylation reaction,stimulation | protein kinase assay | InnateDB,SignaLink |
MAPK1 | MKNK2 | 12897141 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
ELAVL1 | MKNK2 | 19322201 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
MAPK14 | MKNK2 | 23331499 9155017 | stimulation | N/A | SignaLink |
MAPK3 | MKNK2 | 23331499 9155017 | stimulation | N/A | SignaLink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | MKNK2 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
ESR1 | MKNK2 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
ETS1 | MKNK2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
GATA2 | MKNK2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
TFAP2C | MKNK2 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
SMARCA4 | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ZNF263 | MKNK2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ESR2 | MKNK2 | 11013076 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS0000237AF9 | MKNK2 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000122ED0 | MKNK2 | 19088304 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS00001B341F | MKNK2 | 20371350 23592263 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
URS000009262D | MKNK2 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
URS0000079D48 | MKNK2 | 20371350 23592263 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
URS00000BE495 | MKNK2 | 22012620 23592263 23622248 24398324 25416803 27292025 | mrna cleavage,inhibition | clip,clash | TarBase |
URS000005481D | MKNK2 | 23622248 24398324 25416803 27292025 | mrna cleavage,inhibition | clip,clash | TarBase |
URS0000065FDF | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000246356 | MKNK2 | 22012620 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000116F83 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001067D1 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000002103A | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000025EABA | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000042E1F | MKNK2 | 20371350 22012620 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000600E6 | MKNK2 | 20371350 22012620 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002367FA | MKNK2 | 23592263 24398324 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000078918 | MKNK2 | 23592263 24398324 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000098B3B | MKNK2 | 20371350 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000010BD8D | MKNK2 | 20371350 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000049FAE8 | MKNK2 | 20371350 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000000EF0B | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000D0BB4 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000016FD1A | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000105D19 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075D860 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000B7E30 | MKNK2 | 20371350 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000006BE7D | MKNK2 | 20371350 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003B59DF | MKNK2 | 20371350 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000006F90B | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002B3783 | MKNK2 | 20371350 22012620 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000298BA3 | MKNK2 | 20371350 22012620 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000039E1E1 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000DDD35 | MKNK2 | 20371350 22012620 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002075FA | MKNK2 | 20371350 22012620 22473208 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000027080C | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000070CD2 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000346991 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000508C13 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000041E949 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000000E601 | MKNK2 | 20371350 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000000C73C | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000210075 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004F2EB0 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000330617 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000013ABA3 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002A79D1 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075D15B | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00003758F0 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001F5B39 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002C7B2B | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000EED18 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000821E0 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000C403E | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000077DDE | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000C48FA | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000353492 | MKNK2 | 22012620 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001A7F58 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000B989F | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002FC5B0 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000C85B2 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00004AC389 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000016D2D4 | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001B968D | MKNK2 | 23592263 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000060AABB | MKNK2 | 22012620 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000032D69B | MKNK2 | 22012620 23592263 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001B12A4 | MKNK2 | 24398324 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000331800 | MKNK2 | 24398324 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000075BDA4 | MKNK2 | 22012620 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001C770D | MKNK2 | 22012620 24398324 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000CF1D2 | MKNK2 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000075AB16 | MKNK2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000605E00 | MKNK2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000535FDD | MKNK2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000009265 | MKNK2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000058863C | MKNK2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000027352D | MKNK2 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000043D2C1 | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000008AA34 | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000118224 | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002C02E4 | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000239117 | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000D0874 | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000272A92 | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000435A77 | MKNK2 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001F0C23 | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00002EF20A | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000012A1DD | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS0000171525 | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS0000160683 | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS0000022AAA | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000005D4F5 | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000055BBE5 | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00005F1B8C | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000023F008 | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000015A0D9 | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00001A122A | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS000041FA2C | MKNK2 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
NUDT21 | MKNK2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
VBP1 | MKNK2 | 25348397 | N/A | physical interaction | ComPPI |
MAPK1 | MKNK2 | 11013076 14525934 25348397 9155017 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid | ComPPI,HPRD |
MAPK8 | MKNK2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
EIF4G1 | MKNK2 | 25348397 | N/A | physical interaction | ComPPI |
MAPK14 | MKNK2 | 12897141 14525934 20936779 23602568 24234451 25241761 25348397 | association,physical association | experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,tandem affinity purification,proximity ligation assay | ComPPI,HPRD,IntAct |
RBM4 | MKNK2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
RBX1 | MKNK2 | 25348397 | N/A | physical interaction | ComPPI |
BAG6 | MKNK2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
WWP2 | MKNK2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | ESR2 | 11013076 14525934 25348397 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD |
MKNK2 | ESR1 | 11013076 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
MKNK2 | EIF4E | 12897141 14525934 25348397 9155017 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
MKNK2 | RPL7A | 20936779 24234451 25348397 | physical association | physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach | ComPPI,IntAct |
MKNK2 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | VHL | 16856496 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
MKNK2 | CUL2 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | VCL | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | SYMPK | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | KHSRP | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | NOLC1 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | WDR46 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | USP15 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | TRAP1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | CELF1 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | EXOC3 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | RAB11FIP2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | PLXNA3 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | HAUS7 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | ADCK1 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | RBM26 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | BHLHE41 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | TUT7 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | ZMYM1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | CD99L2 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | MRRF | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | TICAM1 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | RICTOR | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
MKNK2 | SRPK1 | 23602568 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
MKNK2 | LRRK2 | 24234451 24947832 25348397 | N/A | protein array | ComPPI,IntAct |
CSTF2 | MKNK2 | 25348397 | N/A | physical interaction | ComPPI |
MIF | MKNK2 | 24234451 25348397 26496610 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MKNK2 | MKNK2 | 11013076 14525934 20936779 24234451 | physical association | two hybrid pooling approach,two hybrid | HPRD,IntAct |
MKNK2 | SFPQ | 17965020 18669648 27898060 | N/A | N/A | OmniPath |
MAPK3 | MKNK2 | 27898060 9155017 | stimulant | N/A | OmniPath |
MAPK14 | MKNK2 | 12897141 20936779 23602568 25241761 26186194 27898060 9155017 | stimulant | N/A | OmniPath |
MAPK1 | MKNK2 | 11013076 12897141 27898060 9155017 | stimulant | N/A | OmniPath |
MKNK2 | MAPK1 | 11013076 12897141 27898060 9155017 | N/A | N/A | OmniPath |
MKNK2 | EIF4E | 11154262 11463832 12897141 17724079 27898060 3112145 7665584 7782323 9155017 | stimulant | N/A | OmniPath |
MKNK2 | PLEC | 23843618 27898060 | N/A | N/A | OmniPath |
MKNK2 | HNRNPA1 | 16111636 19413330 27898060 | N/A | N/A | OmniPath |