Gene Information gene info

GENE:MKNK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MKNK2
FullNmae MAPK interacting serine/threonine kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7111
EnsembleID ENSG00000099875
Uniprot Q9HBH9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MKNK2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MKNK2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MKNK2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MKNK2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MKNK2 GO:0004674,GO:0004683,GO:0005515,GO:0005516,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0006417,GO:0006468,GO:0007166,GO:0009931,GO:0016604,GO:0016605,GO:0018105,GO:0030097,GO:0035556,GO:0035556,GO:0046777,GO:0046872,GO:0071243,GO:0097192,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MKNK2 hsa:2872 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MKNK2 hsa:2872 path:hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
MKNK2 hsa:2872 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MKNK2 EIF4E 11463832 12897141 23180781 23331499 9155017 phosphorylation reaction,stimulation protein kinase assay InnateDB,SignaLink
MAPK1 MKNK2 12897141 23180781 physical association anti tag coimmunoprecipitation InnateDB
ELAVL1 MKNK2 19322201 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAPK14 MKNK2 23331499 9155017 stimulation N/A SignaLink
MAPK3 MKNK2 23331499 9155017 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MKNK2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 MKNK2 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 MKNK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MKNK2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C MKNK2 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MKNK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ESR2 MKNK2 11013076 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 MKNK2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000122ED0 MKNK2 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00001B341F MKNK2 20371350 23592263 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000009262D MKNK2 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS0000079D48 MKNK2 20371350 23592263 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00000BE495 MKNK2 22012620 23592263 23622248 24398324 25416803 27292025 mrna cleavage,inhibition clip,clash TarBase
URS000005481D MKNK2 23622248 24398324 25416803 27292025 mrna cleavage,inhibition clip,clash TarBase
URS0000065FDF MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 MKNK2 22012620 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000116F83 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000002103A MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F MKNK2 20371350 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 MKNK2 20371350 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002367FA MKNK2 23592263 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000078918 MKNK2 23592263 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000098B3B MKNK2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000010BD8D MKNK2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 MKNK2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000105D19 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075D860 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 MKNK2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D MKNK2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF MKNK2 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 MKNK2 20371350 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 MKNK2 20371350 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 MKNK2 20371350 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA MKNK2 20371350 22012620 22473208 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 MKNK2 20371350 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000210075 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002A79D1 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075D15B MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C403E MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000077DDE MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000353492 MKNK2 22012620 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004AC389 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000016D2D4 MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001B968D MKNK2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB MKNK2 22012620 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000032D69B MKNK2 22012620 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001B12A4 MKNK2 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000331800 MKNK2 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075BDA4 MKNK2 22012620 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D MKNK2 22012620 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 MKNK2 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB16 MKNK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000605E00 MKNK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD MKNK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000009265 MKNK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000058863C MKNK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D MKNK2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000043D2C1 MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000239117 MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0874 MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 MKNK2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002EF20A MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000012A1DD MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000171525 MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000160683 MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000022AAA MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000005D4F5 MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000055BBE5 MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005F1B8C MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023F008 MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001A122A MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041FA2C MKNK2 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MKNK2 SFPQ 22135298 phosphorylation N/A PhosphoSite
MKNK2 SPRY2 22135298 phosphorylation N/A PhosphoSite
MKNK2 EIF4E 22135298 phosphorylation N/A PhosphoSite
MKNK2 PLEC 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
NUDT21 MKNK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VBP1 MKNK2 25348397 N/A physical interaction ComPPI
MAPK1 MKNK2 11013076 14525934 25348397 9155017 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
MAPK8 MKNK2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
EIF4G1 MKNK2 25348397 N/A physical interaction ComPPI
MAPK14 MKNK2 12897141 14525934 20936779 23602568 24234451 25241761 25348397 association,physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,tandem affinity purification,proximity ligation assay ComPPI,HPRD,IntAct
RBM4 MKNK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RBX1 MKNK2 25348397 N/A physical interaction ComPPI
BAG6 MKNK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWP2 MKNK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 ESR2 11013076 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MKNK2 ESR1 11013076 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MKNK2 EIF4E 12897141 14525934 25348397 9155017 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MKNK2 RPL7A 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MKNK2 ELAVL1 25348397 N/A physical interaction ComPPI
MKNK2 VHL 16856496 25348397 27898060 N/A physical interaction ComPPI,OmniPath
MKNK2 CUL2 25348397 N/A physical interaction ComPPI
MKNK2 VCL 25348397 N/A physical interaction ComPPI
MKNK2 SYMPK 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 KHSRP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 NOLC1 25348397 N/A physical interaction ComPPI
MKNK2 WDR46 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 USP15 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 TRAP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 CELF1 25348397 N/A physical interaction ComPPI
MKNK2 EXOC3 25348397 N/A physical interaction ComPPI
MKNK2 RAB11FIP2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 PLXNA3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 HAUS7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 ADCK1 25348397 N/A physical interaction ComPPI
MKNK2 RBM26 25348397 N/A physical interaction ComPPI
MKNK2 BHLHE41 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 TUT7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 ZMYM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 CD99L2 25348397 N/A physical interaction ComPPI
MKNK2 MRRF 25348397 N/A physical interaction ComPPI
MKNK2 TICAM1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 RICTOR 25348397 N/A physical interaction ComPPI
MKNK2 TRIM25 25348397 N/A physical interaction ComPPI
MKNK2 SRPK1 23602568 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
MKNK2 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
CSTF2 MKNK2 25348397 N/A physical interaction ComPPI
MIF MKNK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MKNK2 MKNK2 11013076 14525934 20936779 24234451 physical association two hybrid pooling approach,two hybrid HPRD,IntAct
MKNK2 SFPQ 17965020 18669648 27898060 N/A N/A OmniPath
MAPK3 MKNK2 27898060 9155017 stimulant N/A OmniPath
MAPK14 MKNK2 12897141 20936779 23602568 25241761 26186194 27898060 9155017 stimulant N/A OmniPath
MAPK1 MKNK2 11013076 12897141 27898060 9155017 stimulant N/A OmniPath
MKNK2 MAPK1 11013076 12897141 27898060 9155017 N/A N/A OmniPath
MKNK2 EIF4E 11154262 11463832 12897141 17724079 27898060 3112145 7665584 7782323 9155017 stimulant N/A OmniPath
MKNK2 PLEC 23843618 27898060 N/A N/A OmniPath
MKNK2 HNRNPA1 16111636 19413330 27898060 N/A N/A OmniPath

Visualization