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GENE：MAP4K4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP4K4
FullNmae mitogen-activated protein kinase kinase kinase kinase 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6866
EnsembleID ENSG00000071054
Uniprot O95819

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP4K4 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP4K4 GO:0000165,GO:0001953,GO:0004111,GO:0004674,GO:0004674,GO:0005515,GO:0005524,GO:0005737,GO:0005737,GO:0005925,GO:0006468,GO:0006468,GO:0008017,GO:0030335,GO:0032014,GO:0035556,GO:0043066,GO:0043408,GO:0043547,GO:0046328,GO:0048812,GO:0051549,GO:0051894,GO:0106310,GO:0120183

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP4K4 hsa:9448 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP4K4 MAP3K7 10807933 23180781 23331499 9890973 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
MAP4K4 BIRC2 20184394 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP4K4 MAP3K1 23331499 8824585 stimulation N/A SignaLink
PEBP1 MAP4K4 11585904 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
DOK1 MAP4K4 20005715 interaction type N/A PSP,SignaLink
NCK1 MAP4K4 20005715 interaction type N/A PSP
SLC9A1 MAP4K4 20005715 interaction type N/A PSP
NCK1 MAP4K4 20005715 20005715 21071413 9135144 N/A N/A SignaLink
SLC9A1 MAP4K4 20005715 20005715 20936779 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP4K4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 MAP4K4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 MAP4K4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 MAP4K4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 MAP4K4 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MAP4K4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP4K4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 MAP4K4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 MAP4K4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000001EB3 MAP4K4 22948084 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS000003E1A9 MAP4K4 24013097 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000027080C MAP4K4 25416803 26602079 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000005CF5F MAP4K4 25416803 25995320 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
MAP4K4 RDX 22135298 phosphorylation N/A PhosphoSite
MAP4K4 EZR 22135298 phosphorylation N/A PhosphoSite
MAP4K4 MSN 22135298 phosphorylation N/A PhosphoSite
NCK1 MAP4K4 25361965 interaction type N/A PTMCode2
MAP4K4 NCK1 25361965 interaction type N/A PTMCode2
SLC9A1 MAP4K4 25361965 interaction type N/A PTMCode2
MAP4K4 SLC9A1 25361965 interaction type N/A PTMCode2
MAP4K4 MAP3K1 25361965 interaction type N/A PTMCode2
MAP3K1 MAP4K4 25361965 interaction type N/A PTMCode2
MAP4K4 MAP4K4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 MAP4K4 25348397 N/A physical interaction ComPPI
PPP1CC MAP4K4 25348397 N/A two hybrid,physical interaction ComPPI
NANOS2 MAP4K4 25348397 N/A physical interaction ComPPI
STRN MAP4K4 25348397 N/A physical interaction ComPPI
HSP90AB1 MAP4K4 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
TEX264 MAP4K4 25348397 N/A physical interaction ComPPI
DOK1 MAP4K4 25348397 N/A in vivo ComPPI
NCK1 MAP4K4 25348397 N/A physical interaction,in vitro,in vivo ComPPI
JUN MAP4K4 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
PRKCE MAP4K4 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
ITGB1 MAP4K4 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PAXIP1 MAP4K4 25348397 N/A physical interaction ComPPI
SLC9A1 MAP4K4 20936779 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,IntAct
MAP4K4 GBP3 12387898 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction,in vitro,in vivo ComPPI,IntAct
MAP4K4 CASP8 25348397 N/A in vivo ComPPI
MAP4K4 MAP3K7 25348397 N/A in vitro,in vivo ComPPI
MAP4K4 RAP2A 25348397 N/A two hybrid ComPPI
MAP4K4 RASA1 25348397 N/A physical interaction,in vivo ComPPI
MAP4K4 BRCA1 25348397 N/A physical interaction ComPPI
MAP4K4 MAP3K1 25348397 N/A physical interaction ComPPI
MAP4K4 ZRANB1 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP4K4 KIF5A 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP4K4 H2BC21 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP4K4 KIF26B 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP4K4 PPP1CA 22321011 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K4 GRK5 25348397 N/A physical interaction ComPPI
MAP4K4 HSP90AA1 25348397 N/A physical interaction ComPPI
MAP4K4 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP4K4 NME7 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP4K4 MOB1B 24234451 24255178 25348397 colocalization physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MAP4K4 TBPL2 25348397 N/A physical interaction ComPPI
MAP4K4 OBSL1 25348397 N/A physical interaction ComPPI
MAP4K4 MINK1 24234451 25348397 25852190 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP4K4 SLC25A41 25348397 N/A physical interaction ComPPI
MAP4K4 PTGER3 25348397 N/A physical interaction ComPPI
MAP4K4 LTBR 25348397 N/A physical interaction ComPPI
MAP4K4 HEPACAM2 25348397 N/A physical interaction ComPPI
MAP4K4 NTRK1 25348397 N/A physical interaction ComPPI
MAP4K4 CDK12 25348397 N/A physical interaction ComPPI
MAP4K4 NOP2 25348397 N/A physical interaction ComPPI
MAP4K4 CEP152 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MAP4K4 CNTRL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MAP4K4 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
MAP4K4 XPO1 25348397 N/A physical interaction ComPPI
MAP4K4 PPP2CB 25348397 N/A physical interaction ComPPI
MAP4K4 FGFR1OP2 25348397 N/A physical interaction ComPPI
MAP4K4 STRN3 25348397 N/A physical interaction ComPPI
MAP4K4 RAP2C 25348397 N/A physical interaction ComPPI
MAP4K4 ATG14 25348397 N/A physical interaction ComPPI
MAP4K4 CNOT11 25348397 N/A physical interaction ComPPI
MAP4K4 MANSC1 25348397 N/A physical interaction ComPPI
MAP4K4 TRIM25 25348397 N/A physical interaction ComPPI
MAP4K4 G3BP1 25348397 N/A physical interaction ComPPI
MAP4K4 MDM2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
MAP4K4 PPARG 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
RNH1 MAP4K4 25348397 N/A physical interaction ComPPI
LRRC59 MAP4K4 24234451 30021884 physical association cross-linking study IntAct
MAP3K7 MAP4K4 10807933 27898060 9890973 stimulant N/A OmniPath
MAP4K4 MAP3K7 10807933 27898060 9890973 stimulant N/A OmniPath
MAP4K4 MAP3K1 27898060 8824585 stimulant N/A OmniPath
PEBP1 MAP4K4 11585904 27898060 stimulant N/A OmniPath
MAP4K4 BIRC2 20184394 27898060 N/A N/A OmniPath

Visualization










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