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GENE：MSH6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MSH6
FullNmae mutS homolog 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7329
EnsembleID ENSG00000116062
Uniprot P52701

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MSH6 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MSH6 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MSH6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MSH6 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MSH6 GO:0000287,GO:0000400,GO:0000710,GO:0000785,GO:0003682,GO:0003690,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005794,GO:0005829,GO:0006281,GO:0006298,GO:0006298,GO:0006298,GO:0006298,GO:0007283,GO:0008094,GO:0008340,GO:0008630,GO:0009411,GO:0016446,GO:0016447,GO:0019899,GO:0030983,GO:0030983,GO:0032137,GO:0032142,GO:0032143,GO:0032301,GO:0032301,GO:0032301,GO:0032357,GO:0032405,GO:0035064,GO:0043231,GO:0043531,GO:0045190,GO:0045910,GO:0051096,GO:0097193,GO:0140664

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MSH6 hsa:2956 path:hsa01524 Platinum drug resistance - Homo sapiens (human)
MSH6 hsa:2956 path:hsa03430 Mismatch repair - Homo sapiens (human)
MSH6 hsa:2956 path:hsa05200 Pathways in cancer - Homo sapiens (human)
MSH6 hsa:2956 path:hsa05210 Colorectal cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 MSH6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MSH6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MSH6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MSH6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MSH6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MSH6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP3 MSH6 14585961 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 MSH6 20351277 rna interference,inhibition western blot,northern blot,miRNA interference luciferase reporter assay miRSponge
URS000009262D MSH6 21078976 rna interference,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000338542 MSH6 20351277 25416803 mrna cleavage,inhibition western blot,northern blot,miRNA interference luciferase reporter assay TarBase
URS000009262D MSH6 21078976 25416803 mrna cleavage,inhibition western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000AA464 MSH6 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 MSH6 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 MSH6 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS0000070B1D MSH6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 MSH6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005651EE MSH6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000052E1A6 MSH6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D MSH6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 MSH6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000183BED MSH6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001E0AEA MSH6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000081E1F MSH6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B MSH6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000277201 MSH6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000036B845 MSH6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000358C16 MSH6 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 MSH6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 MSH6 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 MSH6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002C28B2 MSH6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000016E46F MSH6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001C04A2 MSH6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000122ED0 MSH6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002F8148 MSH6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000324096 MSH6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FFA8C MSH6 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SNW1 MSH6 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L MSH6 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CEP19 MSH6 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
PCNA MSH6 11005803 11274057 12171929 14525934 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
MSH3 MSH6 25348397 N/A physical interaction ComPPI
RAD21 MSH6 25348397 N/A physical interaction ComPPI
KEAP1 MSH6 25348397 N/A physical interaction ComPPI
AIM2 MSH6 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
HRAS MSH6 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ATR MSH6 25348397 N/A physical interaction ComPPI
PRKDC MSH6 25348397 N/A physical interaction ComPPI
CREBBP MSH6 14525934 16051665 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EP300 MSH6 14525934 16051665 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CUL3 MSH6 25348397 N/A physical interaction ComPPI
NTRK1 MSH6 25348397 N/A physical interaction ComPPI
XRCC5 MSH6 25348397 N/A physical interaction ComPPI
PARP2 MSH6 25348397 N/A physical interaction ComPPI
FEN1 MSH6 25348397 N/A physical interaction ComPPI
CHAF1A MSH6 25348397 N/A physical interaction ComPPI
HUS1 MSH6 25348397 N/A physical interaction ComPPI
RAD9A MSH6 25348397 N/A physical interaction ComPPI
MUTYH MSH6 11801590 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
POLE MSH6 25348397 N/A physical interaction ComPPI
MSH6 MSH2 10856833 14525934 19377479 24234451 25241761 25348397 26496610 8942985 9774676 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,ion exchange chromatography,in vitro,in vivo,proximity ligation assay,two hybrid ComPPI,HPRD,IntAct
MSH6 BRCA1 25348397 N/A physical interaction ComPPI
MSH6 CASP4 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MSH6 MYC 17314511 17353931 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
MSH6 BLM 25348397 N/A physical interaction ComPPI
MSH6 ATM 25348397 N/A physical interaction ComPPI
MSH6 MLH1 25348397 N/A physical interaction ComPPI
MSH6 BARD1 25348397 N/A physical interaction ComPPI
MSH6 MRE11 25348397 N/A physical interaction ComPPI
MSH6 NBN 25348397 N/A physical interaction ComPPI
MSH6 RAD50 25348397 N/A physical interaction ComPPI
MSH6 RFC1 25348397 N/A physical interaction ComPPI
MSH6 SMC1A 25348397 N/A physical interaction ComPPI
MSH6 PMS2 25348397 N/A physical interaction ComPPI
MSH6 PMS2CL 25348397 N/A physical interaction ComPPI
MSH6 AIRE 25348397 N/A physical interaction ComPPI
MSH6 TOPBP1 25348397 N/A physical interaction ComPPI
MSH6 CLSPN 25348397 N/A physical interaction ComPPI
MSH6 CHEK1 25348397 N/A physical interaction ComPPI
MSH6 PRKCZ 25348397 N/A physical interaction ComPPI
MSH6 MORF4L1 25348397 N/A physical interaction ComPPI
MSH6 DTL 25348397 N/A physical interaction ComPPI
MSH6 SMARCAD1 25348397 N/A physical interaction ComPPI
MSH6 PMS1 25348397 N/A physical interaction ComPPI
MSH6 TP53 25348397 N/A physical interaction ComPPI
MSH6 RAD51 25348397 N/A physical interaction ComPPI
MSH6 XRCC6 25348397 N/A physical interaction ComPPI
MSH6 SIRT7 25348397 N/A physical interaction ComPPI
MSH6 FBXO25 25348397 N/A physical interaction ComPPI
MSH6 SLX4 25348397 N/A physical interaction ComPPI
MSH6 RAD1 25348397 N/A physical interaction ComPPI
MSH6 SUPT16H 25348397 N/A physical interaction ComPPI
MSH6 CSNK2A1 25348397 N/A physical interaction,protein kinase assay ComPPI
MSH6 HDAC11 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MSH6 GANAB 25348397 N/A physical interaction ComPPI
MSH6 HYOU1 25348397 N/A physical interaction ComPPI
MSH6 SAMHD1 25348397 N/A physical interaction ComPPI
MSH6 SUPT5H 25348397 N/A physical interaction ComPPI
MSH6 POLK 25348397 N/A physical interaction ComPPI
MSH6 SIRT6 25348397 N/A physical interaction ComPPI
MSH6 RPS6KB2 25348397 N/A physical interaction ComPPI
MSH6 UNK 25348397 N/A physical interaction ComPPI
MSH6 ANKRD17 25348397 N/A physical interaction ComPPI
MSH6 HDGF 25348397 N/A physical interaction ComPPI
MSH6 PRDX1 25348397 N/A physical interaction ComPPI
MSH6 PRDX2 25348397 N/A physical interaction ComPPI
MSH6 SMC3 25348397 N/A physical interaction ComPPI
MSH6 DECR1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MSH6 STX3 25348397 N/A physical interaction ComPPI
MSH6 RUSC2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MSH6 KIAA1191 25348397 N/A physical interaction ComPPI
MSH6 CHD8 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MSH6 BRINP1 25348397 N/A physical interaction ComPPI
MSH6 RNF126 25348397 N/A physical interaction ComPPI
MSH6 FAF2 25348397 N/A physical interaction ComPPI
MSH6 POU5F1 25348397 N/A physical interaction ComPPI
MSH6 ZNF746 25348397 N/A physical interaction ComPPI
MSH6 CDC14B 25348397 N/A physical interaction ComPPI
MSH6 NCL 25348397 N/A physical interaction ComPPI
MSH6 CYLD 25348397 N/A physical interaction ComPPI
MSH6 TRIM25 25348397 N/A physical interaction ComPPI
MSH6 G3BP1 25348397 N/A physical interaction ComPPI
MSH6 HDAC6 25348397 N/A physical interaction ComPPI
MSH6 MCM9 25348397 N/A physical interaction ComPPI
MSH6 UHRF1 25348397 N/A physical interaction ComPPI
MSH6 ZUP1 25348397 N/A physical interaction ComPPI
MSH6 MED9 15175163 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MSH6 MCC 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MSH6 PSMD4 16990800 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
MSH6 MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MSH6 GABARAP 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MSH6 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
MSH6 E2F3 22157815 24234451 25348397 association pull down ComPPI,IntAct
MSH6 YY1 23531880 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MSH6 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MSH6 NANS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MSH6 STK4 23386615 24234451 25348397 association tandem affinity purification ComPPI,IntAct
MSH6 ANG 24234451 25348397 28777577 association anti bait coimmunoprecipitation ComPPI,IntAct
MSH6 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
AKR7A2 MSH6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
H3C1 MSH6 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
H3-3A MSH6 25348397 N/A physical interaction ComPPI
ATP6V1B2 MSH6 25348397 N/A physical interaction ComPPI
SGG MSH6 25348397 N/A anti tag coimmunoprecipitation ComPPI
NUDCD1 MSH6 24234451 29021621 association anti tag coimmunoprecipitation IntAct
METTL3 MSH6 24234451 29507755 association anti tag coimmunoprecipitation IntAct
MSH6 BLM 10783165 15064730 27898060 stimulant N/A OmniPath

Visualization










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