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GENE：MUL1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MUL1
FullNmae mitochondrial E3 ubiquitin protein ligase 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:25762
EnsembleID ENSG00000090432
Uniprot Q969V5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MUL1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MUL1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MUL1 GO:0000209,GO:0000266,GO:0002039,GO:0004842,GO:0005515,GO:0005739,GO:0005739,GO:0005739,GO:0005741,GO:0005741,GO:0005777,GO:0006915,GO:0006919,GO:0010637,GO:0010821,GO:0016020,GO:0016567,GO:0016567,GO:0016925,GO:0019789,GO:0030308,GO:0030424,GO:0031625,GO:0031648,GO:0033235,GO:0042802,GO:0043025,GO:0043123,GO:0045824,GO:0046872,GO:0050689,GO:0050821,GO:0051646,GO:0051881,GO:0051898,GO:0060339,GO:0061630,GO:0071360,GO:0071650,GO:0090141,GO:1901028,GO:1903861,GO:1904925

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MUL1 hsa:79594 path:hsa04137 Mitophagy - animal - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAVS MUL1 23180781 23399697 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR MUL1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MUL1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MUL1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MUL1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MUL1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 MUL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MUL1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000192A75 MUL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000BE495 MUL1 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 MUL1 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
UBE2I MUL1 19407830 24234451 25348397 association anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
MAD2L2 MUL1 24234451 25348397 29656893 association anti tag coimmunoprecipitation ComPPI,IntAct
KRTAP10-8 MUL1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
UBE2D1 MUL1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
APPBP2 MUL1 14525934 16189514 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
UBE2R2 MUL1 25348397 N/A physical interaction ComPPI
UBE2E2 MUL1 25348397 N/A physical interaction ComPPI
UBE2E3 MUL1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
UBE2D4 MUL1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDC34 MUL1 25348397 N/A physical interaction ComPPI
VPS35 MUL1 25348397 N/A physical interaction ComPPI
MUL1 UBE2D2 18213395 19407830 19690564 24234451 25348397 27898060 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct,OmniPath
MUL1 UBE2D3 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MUL1 UBE2E1 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MUL1 UBE2L6 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MUL1 UBE2U 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MUL1 UBE2W 19690564 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MUL1 VPS26A 25348397 N/A physical interaction ComPPI
MUL1 UBC 19407830 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
MUL1 SUMO1 19407830 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
MUL1 DNM1L 25348397 N/A physical interaction ComPPI
MUL1 AKT1 25348397 N/A physical interaction ComPPI
MUL1 TP53 25348397 N/A physical interaction ComPPI
MUL1 MAVS 25348397 N/A physical interaction ComPPI
MUL1 TAP1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MUL1 TRAF2 25348397 N/A physical interaction ComPPI
MUL1 UBE2G2 25348397 N/A physical interaction ComPPI
MUL1 UBE2L3 25348397 N/A physical interaction ComPPI
MUL1 GABARAP 25348397 N/A physical interaction ComPPI
MUL1 TRIM9 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MUL1 ULK1 25348397 N/A physical interaction ComPPI
MUL1 ATG13 25348397 N/A physical interaction ComPPI
MUL1 PEX19 25348397 N/A physical interaction ComPPI
MUL1 HAUS7 25348397 N/A physical interaction ComPPI
MUL1 SLC39A4 25348397 N/A physical interaction ComPPI
MUL1 IQCF1 25348397 N/A physical interaction ComPPI
MUL1 TP73 25348397 26435500 27898060 N/A physical interaction ComPPI,OmniPath
MUL1 HTRA2 25348397 N/A physical interaction ComPPI
MUL1 MAP3K7 25348397 N/A physical interaction ComPPI
MUL1 BZW2 25348397 N/A physical interaction ComPPI
MUL1 PPP6R2 25348397 N/A physical interaction ComPPI
MUL1 TRHDE 25348397 N/A physical interaction ComPPI
MUL1 ARMC6 25348397 N/A physical interaction ComPPI
MUL1 RANBP6 25348397 N/A physical interaction ComPPI
MUL1 ERAP1 25348397 N/A physical interaction ComPPI
MUL1 GSDME 25348397 N/A physical interaction ComPPI
MUL1 SLC39A12 25348397 N/A physical interaction ComPPI
MUL1 ATRIP 25348397 N/A physical interaction ComPPI
MUL1 SCN3B 25348397 N/A physical interaction ComPPI
MUL1 CNGA3 25348397 N/A physical interaction ComPPI
MUL1 GUCY1B1 25348397 N/A physical interaction ComPPI
MUL1 TBC1D9 25348397 N/A physical interaction ComPPI
MUL1 STING1 25348397 N/A physical interaction ComPPI
MUL1 UBE2N 25348397 N/A physical interaction ComPPI
MUL1 UBE2V2 25348397 N/A physical interaction ComPPI
MUL1 TANK 24234451 24841215 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
MUL1 REEP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HSCB MUL1 24234451 25348397 28380382 association anti bait coimmunoprecipitation ComPPI,IntAct
MAVS MUL1 23399697 27898060 N/A N/A OmniPath
MUL1 AKT1 22410793 27898060 inhibition N/A OmniPath

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