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GENE：NBN

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NBN
FullNmae nibrin
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7652
EnsembleID ENSG00000104320
Uniprot O60934

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NBN parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NBN mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NBN immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NBN apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NBN apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NBN GO:0000077,GO:0000723,GO:0000724,GO:0000729,GO:0000781,GO:0000781,GO:0000781,GO:0001832,GO:0003684,GO:0003684,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005657,GO:0005730,GO:0005794,GO:0005829,GO:0006302,GO:0007095,GO:0007095,GO:0007405,GO:0016605,GO:0030174,GO:0030330,GO:0030870,GO:0030870,GO:0030870,GO:0030870,GO:0031860,GO:0031954,GO:0032206,GO:0032508,GO:0032508,GO:0033674,GO:0035825,GO:0035861,GO:0042405,GO:0044818,GO:0045190,GO:0050885,GO:0051321,GO:0051726,GO:0070533,GO:0090656,GO:0090737,GO:0097193,GO:0098687,GO:0110025,GO:0140297,GO:1904354

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NBN hsa:4683 path:hsa03440 Homologous recombination - Homo sapiens (human)
NBN hsa:4683 path:hsa04218 Cellular senescence - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NBN ATM 10608806 23180781 phosphorylation reaction in-gel kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR NBN 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 NBN 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 NBN 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 NBN 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYCN NBN 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NBN 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NBN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NBN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NBN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NBN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NBN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NBN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NBN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NBN 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SIRT1 NBN 18692496 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000028BB8 NBN 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 NBN 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 NBN 19074876 25416803 mrna cleavage,inhibition array technology TarBase

Source Target Pmid Interactiontype Methods Database
CDK2 NBN 22135298 phosphorylation N/A PhosphoSite
ATR NBN 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
ATM NBN 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MSH2 NBN 25361965 interaction type N/A PTMCode2
NBN MSH2 25361965 interaction type N/A PTMCode2
NBN TERF1 25361965 interaction type N/A PTMCode2
TERF1 NBN 25361965 interaction type N/A PTMCode2
NBN ATM 25361965 interaction type N/A PTMCode2
NBN FANCD2 25361965 interaction type N/A PTMCode2
FANCD2 NBN 25361965 interaction type N/A PTMCode2
NBN XRCC4 25361965 interaction type N/A PTMCode2
XRCC4 NBN 25361965 interaction type N/A PTMCode2
NBN ATR 25361965 interaction type N/A PTMCode2
NBN BLM 25361965 interaction type N/A PTMCode2
BLM NBN 25361965 interaction type N/A PTMCode2
NBN BRCA1 25361965 interaction type N/A PTMCode2
BRCA1 NBN 25361965 interaction type N/A PTMCode2
NBN CHEK2 25361965 interaction type N/A PTMCode2
CHEK2 NBN 25361965 interaction type N/A PTMCode2
NBN MDC1 25361965 interaction type N/A PTMCode2
MDC1 NBN 25361965 interaction type N/A PTMCode2
NBN SUMO2 25361965 interaction type N/A PTMCode2
SUMO2 NBN 25361965 interaction type N/A PTMCode2
TERF2 NBN 25361965 interaction type N/A PTMCode2
NBN TERF2 25361965 interaction type N/A PTMCode2
RAD50 NBN 25361965 interaction type N/A PTMCode2
NBN RAD50 25361965 interaction type N/A PTMCode2
NME1 NBN 25361965 interaction type N/A PTMCode2
NBN NME1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 NBN 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L NBN 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CBX8 NBN 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
DAXX NBN 24234451 24651726 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
LZTS2 NBN 25348397 N/A physical interaction ComPPI
TP53BP1 NBN 24234451 25348397 29656893 association proximity-dependent biotin identification ComPPI,IntAct
BMI1 NBN 25348397 N/A physical interaction ComPPI
UBE2D1 NBN 25348397 N/A physical interaction ComPPI
SNAI1 NBN 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CELA2B NBN 25348397 N/A physical interaction ComPPI
DPPA4 NBN 25348397 N/A physical interaction ComPPI
AIM2 NBN 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
ATR NBN 14525934 15758953 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PRKDC NBN 14525934 15758953 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EP300 NBN 14525934 16051665 21108945 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct
HIF1A NBN 25348397 N/A physical interaction ComPPI
PAXIP1 NBN 25348397 N/A physical interaction ComPPI
TUBG1 NBN 25348397 N/A physical interaction ComPPI
POLR1G NBN 24234451 25064736 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
PIK3CB NBN 20368419 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
UBE2N NBN 25348397 N/A physical interaction ComPPI
PARP1 NBN 19629035 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
WRN NBN 25348397 N/A physical interaction ComPPI
XRCC5 NBN 14525934 15758953 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RPA1 NBN 25348397 N/A physical interaction ComPPI
MSH6 NBN 25348397 N/A physical interaction ComPPI
ASH2L NBN 17500065 24234451 25348397 physical association molecular sieving ComPPI,IntAct
RAD18 NBN 25348397 N/A physical interaction ComPPI
UBE2B NBN 25348397 N/A physical interaction ComPPI
FANCD2 NBN 12447395 14525934 19609304 24234451 25348397 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,molecular sieving,pull down,physical interaction,ion exchange chromatography,in vivo ComPPI,HPRD,IntAct
BLM NBN 25348397 N/A physical interaction ComPPI
ATM NBN 10608806 10839544 10839545 11252893 14525934 24234451 25348397 25895060 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
RPA2 NBN 25348397 N/A physical interaction ComPPI
RPA3 NBN 25348397 N/A physical interaction ComPPI
TREX1 NBN 25348397 N/A in vivo ComPPI
MDM4 NBN 25348397 N/A physical interaction ComPPI
RBBP8 NBN 22565321 24234451 25348397 25558984 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RNF8 NBN 18001825 24234451 25348397 26869104 colocalization,physical association anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
RRM2B NBN 19015526 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SUMO2 NBN 25348397 N/A physical interaction ComPPI
MDM2 NBN 25348397 N/A physical interaction ComPPI
H3-4 NBN 25348397 N/A physical interaction ComPPI
HSPA4 NBN 25348397 N/A physical interaction ComPPI
SKP2 NBN 25348397 N/A physical interaction ComPPI
CHEK2 NBN 11438675 14525934 24234451 25348397 phosphorylation reaction,colocalization experimental interaction detection,imaging technique,in vitro ComPPI,HPRD,IntAct
HDAC6 NBN 25348397 N/A physical interaction ComPPI
UBE2A NBN 25348397 N/A physical interaction ComPPI
VRK1 NBN 24234451 25348397 26869104 phosphorylation reaction,colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,protein kinase assay,confocal microscopy ComPPI,IntAct
SIRT1 NBN 17612497 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,deacetylase assay ComPPI,IntAct
MDC1 NBN 12607005 14525934 18001824 18583988 18678890 19804756 20224574 24234451 25064736 25348397 29656893 colocalization,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,isothermal titration calorimetry,pull down,physical interaction,imaging technique,in vitro,confocal microscopy,tandem affinity purification,proximity-dependent biotin identification ComPPI,HPRD,IntAct
LIG3 NBN 25348397 N/A physical interaction ComPPI
NAT2 NBN 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
ATRX NBN 24234451 24651726 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKN NBN 25348397 N/A physical interaction ComPPI
H3C1 NBN 25348397 N/A physical interaction ComPPI
CDK9 NBN 14525934 25348397 8170997 8870681 9258347 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BARD1 NBN 25348397 N/A physical interaction ComPPI
BACH1 NBN 25348397 N/A physical interaction ComPPI
DDX1 NBN 25348397 N/A physical interaction ComPPI
H2AX NBN 11110662 12419185 14525934 15733840 16377563 18001824 18001825 18583988 22157895 22565321 24234451 25348397 colocalization,association,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,fluorescence microscopy,in vitro,in vivo,confocal microscopy ComPPI,HPRD,IntAct
MRE11 NBN 10426999 11238951 12419185 14525934 17500065 17612497 22078559 24234451 25348397 9705271 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
NBN TERF1 10913111 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
NBN BRCA1 10426999 10783165 14525934 24234451 25348397 29656893 association experimental interaction detection,physical interaction,in vitro,in vivo,proximity-dependent biotin identification ComPPI,HPRD,IntAct
NBN RAD50 10426999 11238951 14525934 17500065 17612497 19197236 24234451 24651726 25348397 9705271 colocalization,association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,fluorescence microscopy,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
NBN DCLRE1C 14525934 15456891 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NBN CCNE1 12607005 14525934 24234451 25348397 physical association experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
NBN MLH1 25348397 N/A physical interaction ComPPI
NBN MSH2 25348397 N/A physical interaction ComPPI
NBN RFC1 25348397 N/A physical interaction ComPPI
NBN XRCC4 25348397 N/A physical interaction ComPPI
NBN TERF2 19287395 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NBN RECQL5 25348397 N/A physical interaction ComPPI
NBN MCPH1 25348397 N/A physical interaction ComPPI
NBN TOPBP1 25348397 N/A physical interaction ComPPI
NBN KAT5 25348397 N/A physical interaction ComPPI
NBN ATRIP 14525934 15758953 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
NBN IPO5 25348397 N/A physical interaction ComPPI
NBN TLK1 25348397 N/A physical interaction ComPPI
NBN TERF2IP 25348397 N/A physical interaction ComPPI
NBN NCL 25348397 N/A physical interaction ComPPI
NBN MTOR 25348397 N/A physical interaction ComPPI
NBN RICTOR 25348397 N/A physical interaction ComPPI
NBN MAPKAP1 25348397 N/A physical interaction ComPPI
NBN FAM219A 25348397 N/A physical interaction ComPPI
NBN PHRF1 25348397 N/A physical interaction ComPPI
NBN BAP1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NBN CASC3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
NBN MED4 25348397 N/A physical interaction ComPPI
NBN OFD1 24234451 25348397 26638075 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NBN SLX4 25348397 N/A physical interaction ComPPI
NBN NANOGP8 25348397 N/A physical interaction ComPPI
NBN NANOG 25348397 N/A physical interaction ComPPI
NBN POU5F1 25348397 N/A physical interaction ComPPI
NBN EYA2 25348397 N/A physical interaction ComPPI
NBN BMP1 25348397 N/A physical interaction ComPPI
NBN RGS20 25348397 N/A physical interaction ComPPI
NBN BRIP1 25348397 N/A physical interaction ComPPI
NBN MCM9 25348397 N/A physical interaction ComPPI
NBN TCOF1 24234451 25064736 25348397 27898060 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,isothermal titration calorimetry,pull down,physical interaction,tandem affinity purification ComPPI,IntAct,OmniPath
NBN POLR1B 24234451 25064736 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NBN RAD17 24234451 24534091 25348397 association,physical association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
NBN PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
NBN INTS3 19683501 24234451 25348397 physical association pull down ComPPI,IntAct
POLR1A NBN 24234451 25064736 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
ATF2 NBN 14525934 15916964 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK9 NBN 11252893 27898060 N/A N/A OmniPath
CDK2 NBN 22927831 27898060 N/A N/A OmniPath
ATR NBN 10608806 10766245 10802669 10839544 12433983 12447371 12598907 14707289 15733840 15758953 17485521 17526493 18003706 18644472 27898060 stimulant N/A OmniPath
SIRT1 NBN 17612497 27898060 stimulant N/A OmniPath
MRE11 NBN 10426999 10783165 11238951 12419185 12447395 12607003 12679336 15734743 15758953 17500065 17713585 18458108 19244116 19270065 21884979 22078559 22464731 22939629 26455393 27898060 9705271 stimulant N/A OmniPath
NBN ATM 10608806 10783165 10802669 10839544 10839545 11252893 12814430 12861053 15758953 15908798 15964794 16622404 17429352 17507690 18854157 22464731 25088203 27898060 stimulant N/A OmniPath
ATM NBN 10608806 10783165 10802669 10839544 10839545 11252893 12814430 12861053 15279770 15302935 15758953 15964794 17429352 17507690 17525332 18669648 18854157 19413330 20068231 22464731 25088203 27898060 stimulant N/A OmniPath
MDC1 NBN 12607003 12607005 14519663 15201865 15377652 18001824 18583988 18678890 19230643 19804756 20224574 20460517 23115235 27898060 stimulant N/A OmniPath
RPA2 NBN 19586055 27898060 stimulant N/A OmniPath
H2AX NBN 11110662 12419185 15201865 15635255 15733840 16932743 18001824 18001825 21676867 22157895 22565321 23145133 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B7504 NBN 27087310 direct interaction,inhibition N/A NPInter

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