GENE：MAPK4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | MAPK4 |
| FullNmae | mitogen-activated protein kinase 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6878 |
| EnsembleID | ENSG00000141639 |
| Uniprot | P31152 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| MAPK4 | necroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| MAPK4 | GO:0000165,GO:0004674,GO:0004674,GO:0004707,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005737,GO:0005737,GO:0005829,GO:0006468,GO:0007049,GO:0019901,GO:0035556,GO:0042803,GO:0046982,GO:0106310 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| MAPK4 | hsa:5596 | path:hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | MAPK4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | MAPK4 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | MAPK4 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | MAPK4 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | MAPK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | MAPK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | MAPK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | MAPK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | MAPK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | MAPK4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | MAPK4 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000007340 | MAPK4 | 23880861 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CALML3 | MAPK4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| HSP90AB1 | MAPK4 | 22939624 24234451 25348397 | physical association | anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| CRK | MAPK4 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| GAB2 | MAPK4 | 12008033 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| MAPKAPK5 | MAPK4 | 14525934 18720373 23602568 24234451 25348397 | association | experimental interaction detection,physical interaction,in vivo,tandem affinity purification | ComPPI,HPRD,IntAct |
| GAB1 | MAPK4 | 12008033 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| HSP90AA1 | MAPK4 | 25348397 | N/A | physical interaction | ComPPI |
| FASTKD5 | MAPK4 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK4 | CCND3 | 14525934 16360641 25348397 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| MAPK4 | ERC1 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK4 | TECR | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK4 | PSMA7 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK4 | SFXN2 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK4 | ACSL3 | 25348397 | N/A | physical interaction | ComPPI |
| MAPK4 | ATP1A1 | 23602568 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| MAPK4 | DUSP2 | 25348397 | N/A | physical interaction | ComPPI |
| PAK1 | MAPK4 | 18669648 21177870 27898060 | N/A | N/A | OmniPath |
| MAPK4 | HOXA10 | 12145285 27898060 | N/A | N/A | OmniPath |
| MAPKAPK5 | MAPK4 | 1319925 18720373 21675959 23602568 27898060 | stimulant | N/A | OmniPath |