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GENE：NF1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NF1
FullNmae neurofibromin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7765
EnsembleID ENSG00000196712
Uniprot P21359

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NF1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NF1 GO:0000165,GO:0001525,GO:0001649,GO:0001656,GO:0001666,GO:0001889,GO:0001935,GO:0001937,GO:0001938,GO:0001952,GO:0001953,GO:0002686,GO:0005096,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005737,GO:0005829,GO:0005886,GO:0006469,GO:0006606,GO:0007154,GO:0007265,GO:0007405,GO:0007406,GO:0007420,GO:0007422,GO:0007507,GO:0007519,GO:0008429,GO:0008542,GO:0008625,GO:0010468,GO:0010626,GO:0014010,GO:0014044,GO:0016020,GO:0016525,GO:0016601,GO:0021510,GO:0021764,GO:0021897,GO:0021915,GO:0021987,GO:0022011,GO:0030036,GO:0030198,GO:0030199,GO:0030316,GO:0030325,GO:0030336,GO:0030424,GO:0030425,GO:0031210,GO:0032228,GO:0033024,GO:0033027,GO:0034605,GO:0035021,GO:0036135,GO:0042060,GO:0042308,GO:0043065,GO:0043087,GO:0043407,GO:0043409,GO:0043409,GO:0043473,GO:0043491,GO:0043525,GO:0043535,GO:0043547,GO:0043547,GO:0043547,GO:0045124,GO:0045671,GO:0045685,GO:0045762,GO:0045765,GO:0046929,GO:0048144,GO:0048147,GO:0048169,GO:0048485,GO:0048593,GO:0048709,GO:0048712,GO:0048715,GO:0048745,GO:0048820,GO:0048844,GO:0048853,GO:0050890,GO:0051402,GO:0060291,GO:0061534,GO:0061535,GO:0070372,GO:0070662,GO:0070667,GO:0072089,GO:0097192,GO:0097529,GO:0098597,GO:0098793,GO:0098978,GO:0099175,GO:1900148,GO:1900271,GO:1904707,GO:1904738,GO:1904753,GO:1990874,GO:2000647,GO:2001241

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NF1 hsa:4763 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
NF1 hsa:4763 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
NF1 hsa:4763 path:hsa04014 Ras signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HRAS NF1 23180781 8628317 physical association two hybrid InnateDB
NF1 IRF8 15371411 16914719 17200120 19801548 23180781 physical association anti tag coimmunoprecipitation,electrophoretic mobility shift assay InnateDB
NF1 SPI1 17200120 23180781 physical association anti tag coimmunoprecipitation InnateDB
NF1 IRF2 17200120 23180781 physical association anti tag coimmunoprecipitation InnateDB
TIRAP NF1 21903422 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR NF1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 NF1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 NF1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NF1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 NF1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 NF1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 NF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NF1 18971253 21111075 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NF1 18971253 8495744 trascriptional regulation,stimulation inferred by curator TFlink
FOS NF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF NF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 NF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NF1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CREB1 NF1 10435592 trascriptional regulation,stimulation inferred by curator TFlink
GFI1 NF1 14504408 trascriptional regulation,stimulation inferred by curator TFlink
IRF8 NF1 15371411 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 NF1 15988004 trascriptional regulation,stimulation inferred by curator TFlink
SP1 NF1 10435592 14647436 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 NF1 10435592 14647436 trascriptional regulation,stimulation inferred by curator TFlink
TBP NF1 15767669 trascriptional regulation,stimulation inferred by curator TFlink
TBPL1 NF1 15767669 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 NF1 19051271 trascriptional regulation,stimulation inferred by curator TFlink
TWIST2 NF1 19051271 trascriptional regulation,stimulation inferred by curator TFlink
YY1 NF1 15763658 trascriptional regulation,stimulation inferred by curator TFlink
TFAP2A NF1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004AC389 NF1 20550523 rna interference,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004900F1 NF1 23077663 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004AC389 NF1 20550523 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004900F1 NF1 23077663 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS0000042E1F NF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000AA464 NF1 22473208 23335975 23622248 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,clip,clash,miRNA interference luciferase reporter assay TarBase
URS000000B1C9 NF1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000006FDD4 NF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 NF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000285DCB NF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 NF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F NF1 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF NF1 25416803 27827403 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDC5L NF1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TRAF6 NF1 25348397 N/A physical interaction ComPPI
VCP NF1 22105171 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FAM53C NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CBY1 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
HRAS NF1 25348397 N/A physical interaction,in vitro ComPPI
TIAM1 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SLAMF1 NF1 25348397 N/A physical interaction ComPPI
GAB2 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SUMO1 NF1 17036045 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
HDAC4 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RTKN NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GIGYF1 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SDC2 NF1 11356864 24234451 25348397 physical association two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
YWHAB NF1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAGI1 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CAV1 NF1 25348397 N/A physical interaction ComPPI
SMARCA4 NF1 25348397 N/A physical interaction ComPPI
TIRAP NF1 21903422 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLK1 NF1 25348397 N/A physical interaction ComPPI
PHLDB2 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GRIN2D NF1 25348397 N/A in vivo ComPPI
GRIN1 NF1 25348397 N/A in vivo ComPPI
STARD13 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EPHA1 NF1 25348397 N/A physical interaction ComPPI
EFNB2 NF1 25348397 N/A physical interaction ComPPI
DNAJC7 NF1 25348397 27898060 8836031 N/A in vivo ComPPI,OmniPath
TNFSF13B NF1 25348397 N/A physical interaction ComPPI
EGFR NF1 25348397 N/A physical interaction ComPPI
YWHAH NF1 25348397 N/A physical interaction ComPPI
POLR2A NF1 25348397 N/A physical interaction ComPPI
SH3PXD2A NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PTPN13 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDK16 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
DYNC1H1 NF1 23583712 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
CD274 NF1 25348397 N/A physical interaction ComPPI
TBPL1 NF1 15767669 25348397 27898060 N/A in vivo ComPPI,OmniPath
CD79B NF1 25348397 N/A physical interaction ComPPI
HTR6 NF1 25348397 N/A physical interaction ComPPI
CGN NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KIF13B NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NSFL1C NF1 25348397 N/A physical interaction ComPPI
CDC25B NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
CDC25C NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KIF1C NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
TESK2 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
GIGYF2 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
PML NF1 22293200 24234451 25348397 27898060 colocalization,physical association cross-linking study,physical interaction,proximity ligation assay ComPPI,IntAct,OmniPath
TGOLN2 NF1 25348397 N/A physical interaction ComPPI
SRGAP2 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ZNF638 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SIPA1L1 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
FAF2 NF1 20160012 25348397 26186194 27898060 N/A physical interaction ComPPI,OmniPath
RASAL2 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
ZBTB21 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
RALGPS2 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
EIF4E2 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
KCTD3 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
P4HA3 NF1 25348397 N/A physical interaction ComPPI
NAV1 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
SCN3B NF1 25348397 N/A physical interaction ComPPI
NRAS NF1 25348397 N/A physical interaction ComPPI
USP21 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 SIRT7 25348397 N/A physical interaction ComPPI
NF1 NXF1 25348397 N/A physical interaction ComPPI
NF1 CCDC8 25348397 N/A physical interaction ComPPI
NF1 HLA-DPA1 25348397 N/A physical interaction ComPPI
NF1 CA14 25348397 N/A physical interaction ComPPI
NF1 VSIG4 25348397 N/A physical interaction ComPPI
NF1 NOSIP 25348397 N/A physical interaction ComPPI
NF1 APP 16374483 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct,OmniPath
NF1 VSIG1 25348397 N/A physical interaction ComPPI
NF1 SIGLECL1 25348397 N/A physical interaction ComPPI
NF1 FAM174A 25348397 N/A physical interaction ComPPI
NF1 KSR1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 LRFN1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 MAST3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 DENND1A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 DENND4C 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 PPM1H 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 LIMA1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 DCLK1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 LPIN3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 CAMSAP2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 NADK 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 MAPKAP1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 SRSF12 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 SYDE1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 MAP3K21 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 SH3RF3 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 PLEKHA7 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 OSBPL6 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 FAM110B 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 TANC2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 ANKRD34A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 PTPN14 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 DENND4A 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 INPP5E 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
NF1 ZUP1 25348397 N/A physical interaction ComPPI
AGAP1 NF1 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MKI67 NF1 24234451 26949251 association anti tag coimmunoprecipitation IntAct
NOLC1 NF1 24234451 30021884 physical association cross-linking study IntAct
PRKCA NF1 26490262 27898060 N/A N/A OmniPath
HRAS NF1 27898060 8628317 N/A N/A OmniPath
NF1 HRAS 19718661 27898060 8628317 inhibition,stimulant N/A OmniPath
NF1 NRAS 2116237 2121370 27898060 inhibition N/A OmniPath
TIRAP NF1 21903422 27898060 N/A N/A OmniPath

Visualization










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