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GENE：NGFR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NGFR
FullNmae nerve growth factor receptor
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7809
EnsembleID ENSG00000064300
Uniprot P08138

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NGFR mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NGFR apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NGFR apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NGFR GO:0001540,GO:0001678,GO:0004888,GO:0005035,GO:0005035,GO:0005515,GO:0005516,GO:0005576,GO:0005654,GO:0005654,GO:0005768,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0006886,GO:0006919,GO:0007266,GO:0007266,GO:0007411,GO:0007417,GO:0008543,GO:0009986,GO:0009986,GO:0014069,GO:0015026,GO:0015026,GO:0016020,GO:0016048,GO:0021675,GO:0030336,GO:0030426,GO:0031069,GO:0031267,GO:0031594,GO:0031625,GO:0032922,GO:0035907,GO:0038023,GO:0040037,GO:0042475,GO:0042488,GO:0042593,GO:0043121,GO:0043197,GO:0043204,GO:0048144,GO:0048146,GO:0048406,GO:0048406,GO:0051402,GO:0051799,GO:0098793,GO:0099171,GO:1900182,GO:1902895,GO:1903588,GO:1904646,GO:2001235

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NGFR hsa:4804 path:hsa03265 Virion - Lyssavirus - Homo sapiens (human)
NGFR hsa:4804 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
NGFR hsa:4804 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
NGFR hsa:4804 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
NGFR hsa:4804 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
NGFR hsa:4804 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
NGFR hsa:4804 path:hsa04215 Apoptosis - multiple species - Homo sapiens (human)
NGFR hsa:4804 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
NGFR hsa:4804 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NGF NGFR 10764727 11546791 11756498 12376548 12387875 14673001 15099563 15548667 15721744 16252010 16630834 17488777 17764704 22465479 23314527 25071162 26192618 9841888 interaction type N/A ACSN
NGFR XIAP 10764727 11546791 11756498 12376548 12387875 14673001 15099563 15548667 15721744 16252010 16630834 17488777 17764704 22465479 23314527 25071162 26192618 9841888 interaction type N/A ACSN
APH1A NGFR 16252010 16630834 26192618 interaction type N/A ACSN
APH1B NGFR 16252010 16630834 26192618 interaction type N/A ACSN
NGFR TRAF6 16252010 16630834 26192618 interaction type N/A ACSN
TRAF6 NGFR 11244088 23180781 physical association anti tag coimmunoprecipitation InnateDB
IRAK1 NGFR 14684752 23180781 physical association anti tag coimmunoprecipitation InnateDB
SQSTM1 NGFR 11244088 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CAV1 NGFR 20005715 interaction type N/A PSP
GRB2 NGFR 20005715 interaction type N/A PSP
KIDINS220 NGFR 20005715 interaction type N/A PSP
NFKBIB NGFR 20005715 interaction type N/A PSP
SHC1 NGFR 20005715 interaction type N/A PSP
TRADD NGFR 20005715 interaction type N/A PSP
TRAF1 NGFR 20005715 interaction type N/A PSP
TRAF2 NGFR 20005715 interaction type N/A PSP
TRAF3 NGFR 20005715 interaction type N/A PSP
TRAF5 NGFR 20005715 interaction type N/A PSP
CAV1 NGFR 18988627 20005715 21071413 9867838 N/A N/A SignaLink
SHC1 NGFR 18988627 20005715 20005715 7541035 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 NGFR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NGFR 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TFAP2C NGFR 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 NGFR 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA NGFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NGFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 NGFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NGFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NGFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NGFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NGFR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYCN NGFR 21123453 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 NGFR 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B989F NGFR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005F9738 NGFR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D NGFR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA NGFR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075994C NGFR 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C3AC1 NGFR 25416803 27927008 mrna cleavage,inhibition rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000009EA8F NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009A9A2 NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BD6DC NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000047A8F NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000214763 NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A NGFR 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACB NGFR 22135298 phosphorylation N/A PhosphoSite
PRKCG NGFR 22135298 phosphorylation N/A PhosphoSite
RTN4R NGFR 25361965 interaction type N/A PTMCode2
NGFR RTN4R 25361965 interaction type N/A PTMCode2
NGFR MAPK1 25361965 interaction type N/A PTMCode2
MAPK1 NGFR 25361965 interaction type N/A PTMCode2
NGFR RIPK2 25361965 interaction type N/A PTMCode2
RIPK2 NGFR 25361965 interaction type N/A PTMCode2
NGFR SORT1 25361965 interaction type N/A PTMCode2
SORT1 NGFR 25361965 interaction type N/A PTMCode2
NGFR TRAF4 25361965 interaction type N/A PTMCode2
TRAF4 NGFR 25361965 interaction type N/A PTMCode2
NGFR MAG 25361965 interaction type N/A PTMCode2
MAG NGFR 25361965 interaction type N/A PTMCode2
NGFR NTRK2 25361965 interaction type N/A PTMCode2
NTRK2 NGFR 25361965 interaction type N/A PTMCode2
NGFR APP 25361965 interaction type N/A PTMCode2
APP NGFR 25361965 interaction type N/A PTMCode2
NGFR TRAF6 25361965 interaction type N/A PTMCode2
TRAF6 NGFR 25361965 interaction type N/A PTMCode2
NGFR NDN 25361965 interaction type N/A PTMCode2
NDN NGFR 25361965 interaction type N/A PTMCode2
NGFR SALL2 25361965 interaction type N/A PTMCode2
SALL2 NGFR 25361965 interaction type N/A PTMCode2
NGFR GRB2 25361965 interaction type N/A PTMCode2
GRB2 NGFR 25361965 interaction type N/A PTMCode2
NGFR TRADD 25361965 interaction type N/A PTMCode2
TRADD NGFR 25361965 interaction type N/A PTMCode2
NGFR MAGEH1 25361965 interaction type N/A PTMCode2
MAGEH1 NGFR 25361965 interaction type N/A PTMCode2
NGFR LINGO1 25361965 interaction type N/A PTMCode2
LINGO1 NGFR 25361965 interaction type N/A PTMCode2
NGFR NTRK3 25361965 interaction type N/A PTMCode2
NTRK3 NGFR 25361965 interaction type N/A PTMCode2
NGFR NGF 25361965 interaction type N/A PTMCode2
NGF NGFR 25361965 interaction type N/A PTMCode2
NGFR BEX1 25361965 interaction type N/A PTMCode2
BEX1 NGFR 25361965 interaction type N/A PTMCode2
NGFR MAGED1 25361965 interaction type N/A PTMCode2
MAGED1 NGFR 25361965 interaction type N/A PTMCode2
NGFR FSCN1 25361965 interaction type N/A PTMCode2
FSCN1 NGFR 25361965 interaction type N/A PTMCode2
NGFR SHC1 25361965 interaction type N/A PTMCode2
SHC1 NGFR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TCF19 NGFR 10485890 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TTR NGFR 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CDKN1A NGFR 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TK1 NGFR 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRAF6 NGFR 10514511 14525934 25348397 9915784 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAGEH1 NGFR 12414813 14525934 21418516 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
SMN1 NGFR 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKACB NGFR 12682012 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
BEX1 NGFR 14525934 16498402 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAPK1 NGFR 14525934 25348397 8407983 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SHC1 NGFR 14525934 25348397 7541035 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK3 NGFR 14525934 25348397 8407983 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
GRB2 NGFR 14525934 25348397 9368064 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NTRK1 NGFR 14525934 25348397 9927421 N/A coimmunoprecipitation,cross-linking study,experimental interaction detection,physical interaction,fluorescence microscopy,in vivo ComPPI,HPRD
NGF NGFR 14525934 14985763 24234451 25348397 physical association coimmunoprecipitation,cross-linking study,experimental interaction detection,surface plasmon resonance,physical interaction,biochemical,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
CAV1 NGFR 14525934 25348397 9867838 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IKBKB NGFR 25348397 N/A physical interaction ComPPI
TRAF3 NGFR 25348397 N/A physical interaction ComPPI
NTRK2 NGFR 14525934 25348397 9927421 N/A experimental interaction detection,in vivo ComPPI,HPRD
FSCN1 NGFR 12789270 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
SQSTM1 NGFR 25348397 N/A physical interaction ComPPI
RCC1 NGFR 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TRAF1 NGFR 25348397 N/A physical interaction ComPPI
TRAF2 NGFR 10514511 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NFKBIB NGFR 12034707 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MDM2 NGFR 25348397 N/A physical interaction ComPPI
TRAF5 NGFR 25348397 N/A physical interaction ComPPI
NGFR PTPN13 10544233 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
NGFR LINGO1 14525934 14966521 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NGFR SORT1 14525934 14985763 24234451 25348397 physical association cross-linking study,experimental interaction detection,in vivo ComPPI,HPRD,IntAct
NGFR TRADD 12604596 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NGFR ZNF274 10545116 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NGFR IL2 1316918 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NGFR MAG 12011108 14525934 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
NGFR MAGED1 10985348 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NGFR BEX3 10764727 14525934 17355907 24234451 25348397 association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
NGFR NDN 12414813 12716928 14525934 14593116 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
NGFR TRAF4 10514511 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NGFR TRA2B 12604596 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NGFR RIPK2 11487608 14525934 16498402 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NGFR RTN4R 12422217 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
NGFR KIDINS220 11150334 14525934 15378608 25348397 27898060 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
NGFR NSMCE3 25348397 N/A physical interaction ComPPI
NGFR TRIM37 25348397 N/A physical interaction ComPPI
NGFR UFD1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NGFR H2AX 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NGFR STMN2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NGFR RPN2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NGFR ANXA7 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NGFR BFAR 22566094 25348397 27898060 N/A physical interaction ComPPI,OmniPath
NGFR CD80 21982860 24234451 25348397 physical association protein array,surface plasmon resonance,physical interaction ComPPI,IntAct
NGFR TP53 25348397 N/A physical interaction ComPPI
NGFR APP 19225519 24234451 25348397 N/A pull down,physical interaction,solid phase assay ComPPI,IntAct
NGFR TSC1 17355907 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
NGFR SALL2 19131967 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid ComPPI,IntAct,OmniPath
NGFR SORCS2 24234451 24908487 25348397 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
NTF4 NGFR 14525934 25348397 7541633 N/A experimental interaction detection,in vivo ComPPI,HPRD
NTRK3 NGFR 14525934 9927421 N/A experimental interaction detection HPRD
NGFR NGFR 11756426 24234451 physical association cross-linking study IntAct
NGFR CBL 15337528 27898060 N/A N/A OmniPath
PTPN13 NGFR 10544233 27898060 N/A N/A OmniPath
NGFR TRAF6 10514511 11244088 14960584 23017601 27898060 9915784 N/A N/A OmniPath
NGF NGFR 10764727 11114882 11729324 1372492 14699954 14985763 1714587 2172988 27898060 3037029 stimulant N/A OmniPath
PRKCG NGFR 19710323 27898060 N/A N/A OmniPath
CDK1 NGFR 12682012 27898060 N/A N/A OmniPath
PRKACB NGFR 12682012 26119933 27898060 stimulant N/A OmniPath

Visualization










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