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GENE：NR4A2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NR4A2
FullNmae nuclear receptor subfamily 4 group A member 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7981
EnsembleID ENSG00000153234
Uniprot P43354

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NR4A2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
NR4A2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
NR4A2 GO:0000122,GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001228,GO:0001666,GO:0001764,GO:0001975,GO:0003677,GO:0004879,GO:0005515,GO:0005634,GO:0005634,GO:0005634,GO:0005654,GO:0005667,GO:0005737,GO:0006351,GO:0006357,GO:0006366,GO:0007165,GO:0008013,GO:0008270,GO:0008344,GO:0009791,GO:0016607,GO:0021952,GO:0021953,GO:0021986,GO:0030522,GO:0031668,GO:0032991,GO:0034599,GO:0035259,GO:0042053,GO:0042416,GO:0042551,GO:0043524,GO:0043576,GO:0045444,GO:0045944,GO:0045944,GO:0046965,GO:0046982,GO:0051402,GO:0051866,GO:0060070,GO:0071376,GO:0071376,GO:0071542,GO:0071542,GO:1904948,GO:1990837,GO:2001234

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NR4A2 hsa:4929 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
NR4A2 hsa:4929 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NR4A2 CREB1 15753290 23180781 physical association anti tag coimmunoprecipitation InnateDB
CREBBP NR4A2 15753290 23180781 physical association anti tag coimmunoprecipitation InnateDB
NR4A3 NR4A2 12529383 23331499 stimulation N/A SignaLink,SignaLink
NR4A2 NR4A3 12529383 23331499 stimulation N/A SignaLink,SignaLink
RXRA NR4A2 12122012 15604093 23331499 stimulation N/A SignaLink
NR4A2 RXRA 12122012 15604093 23331499 7705655 7758108 stimulation N/A SignaLink
RXRB NR4A2 15604093 23331499 9636132 stimulation N/A SignaLink
NR4A2 RXRB 15604093 23331499 7705655 7758108 9636132 stimulation N/A SignaLink
RXRG NR4A2 12122012 23331499 stimulation N/A SignaLink
NR4A2 RXRG 12122012 23331499 stimulation N/A SignaLink
NR3C1 NR4A2 15591535 23331499 stimulation N/A SignaLink
NR4A2 NR3C1 15591535 23331499 stimulation N/A SignaLink
NR4A1 NR4A2 12529383 23331499 stimulation N/A SignaLink
NR4A2 NR4A1 12529383 23331499 stimulation N/A SignaLink
CTNNB1 NR4A2 21362399 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR NR4A2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 NR4A2 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 NR4A2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 NR4A2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
RELA NR4A2 20018891 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NR4A2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 NR4A2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF2 NR4A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
CREB1 NR4A2 N/A trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 NR4A2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000006FDD4 NR4A2 19885849 rna interference,inhibition array technology,miRNA interference luciferase reporter assay miRSponge
URS0000060B2B NR4A2 19885849 rna interference,inhibition array technology,miRNA interference luciferase reporter assay miRSponge
URS000041E949 NR4A2 19885849 rna interference,inhibition array technology,miRNA interference luciferase reporter assay miRSponge
URS0000060B2B NR4A2 19885849 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS000006FDD4 NR4A2 19885849 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS000041E949 NR4A2 19885849 25416803 mrna cleavage,inhibition array technology,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 NR4A2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000000E601 NR4A2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000EED18 NR4A2 19536157 25416803 27121375 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS00002C02E4 NR4A2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000034B6F5 NR4A2 25416803 25452104 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
NR4A2 RXRA 25361965 interaction type N/A PTMCode2
RXRA NR4A2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDKN2D NR4A2 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RAN NR4A2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NCOA1 NR4A2 25348397 N/A physical interaction ComPPI
COPS5 NR4A2 14525934 15604093 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
SFPQ NR4A2 25348397 N/A physical interaction ComPPI
GTF2I NR4A2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NCOR2 NR4A2 25348397 N/A physical interaction ComPPI
PPARGC1A NR4A2 25348397 N/A physical interaction ComPPI
SMARCA4 NR4A2 25348397 N/A physical interaction ComPPI
SIN3A NR4A2 25348397 N/A physical interaction ComPPI
CDKN1C NR4A2 14525934 14671317 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
NEFM NR4A2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
PPARG NR4A2 25348397 N/A physical interaction ComPPI
RPS6KA1 NR4A2 14525934 16223362 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NR4A2 RXRB 14525934 15604093 25348397 7705655 7758108 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
NR4A2 PIAS4 14525934 14559918 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
NR4A2 VHL 14525934 18305400 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
NR4A2 SMARCA2 25348397 N/A physical interaction ComPPI
NR4A2 RUNX1 25348397 N/A physical interaction ComPPI
NR4A2 RXRA 14525934 15604093 25348397 7705655 7758108 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
NR4A2 ELAVL1 25348397 N/A physical interaction ComPPI
NR4A2 TCEAL5 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
NR4A2 BAZ1B 20195357 24234451 25348397 physical association display technology,physical interaction ComPPI,IntAct
NR4A2 CISD1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A2 ZCCHC17 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A2 ZNF41 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A2 OPA1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A2 NDUFS5 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A2 ANP32E 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A2 EIF3A 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A2 SUGP2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NR4A2 FDX1 20195357 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
NR4A2 ODAD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RPS6KA1 NR4A2 16223362 27898060 N/A N/A OmniPath
MAPK1 NR4A2 17681692 27898060 stimulant N/A OmniPath
PIAS4 NR4A2 14559918 27898060 N/A N/A OmniPath
RXRB NR4A2 15604093 27898060 7705655 7758108 9636132 stimulant N/A OmniPath

Visualization










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