GENE：NRP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | NRP1 |
| FullNmae | neuropilin 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:8004 |
| EnsembleID | ENSG00000099250 |
| Uniprot | O14786 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| NRP1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| NRP1 | GO:0001525,GO:0001525,GO:0001569,GO:0001570,GO:0001755,GO:0001764,GO:0001938,GO:0002040,GO:0002040,GO:0002042,GO:0002116,GO:0003148,GO:0005021,GO:0005021,GO:0005021,GO:0005096,GO:0005515,GO:0005615,GO:0005769,GO:0005829,GO:0005883,GO:0005886,GO:0005886,GO:0005925,GO:0005925,GO:0005925,GO:0006930,GO:0007165,GO:0007229,GO:0007267,GO:0007411,GO:0007411,GO:0007413,GO:0008201,GO:0009611,GO:0009887,GO:0010595,GO:0010595,GO:0010595,GO:0014911,GO:0015026,GO:0017154,GO:0017154,GO:0019838,GO:0019838,GO:0019901,GO:0019955,GO:0021612,GO:0021637,GO:0021649,GO:0021675,GO:0021785,GO:0021828,GO:0030424,GO:0030424,GO:0030947,GO:0031290,GO:0031410,GO:0031966,GO:0032489,GO:0034446,GO:0035729,GO:0035767,GO:0035924,GO:0036486,GO:0038085,GO:0038085,GO:0038189,GO:0038190,GO:0038190,GO:0042327,GO:0043005,GO:0043235,GO:0043524,GO:0043542,GO:0045211,GO:0045766,GO:0046718,GO:0046872,GO:0048008,GO:0048010,GO:0048010,GO:0048012,GO:0048842,GO:0048843,GO:0048844,GO:0048846,GO:0050731,GO:0050918,GO:0051491,GO:0051491,GO:0051496,GO:0051894,GO:0060301,GO:0060385,GO:0060627,GO:0060666,GO:0060978,GO:0060982,GO:0061299,GO:0061441,GO:0061549,GO:0061551,GO:0070374,GO:0071526,GO:0071679,GO:0090050,GO:0090259,GO:0097102,GO:0097374,GO:0097443,GO:0097475,GO:0097490,GO:0097491,GO:0098978,GO:0099173,GO:0150018,GO:0150020,GO:1900026,GO:1901166,GO:1902285,GO:1902287,GO:1902336,GO:1902378,GO:1902946,GO:1903375,GO:1904835,GO:1905040,GO:2001237 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| NRP1 | hsa:8829 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| NRP1 | hsa:8829 | path:hsa05166 | Human T-cell leukemia virus 1 infection - Homo sapiens (human) |
| NRP1 | hsa:8829 | path:hsa05171 | Coronavirus disease - COVID-19 - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | NRP1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | NRP1 | 18414489 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,chromatin immunoprecipitation assay | TFlink |
| ETS1 | NRP1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | NRP1 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | NRP1 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | NRP1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | NRP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| REST | NRP1 | 16330548 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000237AF9 | NRP1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000021D7C8 | NRP1 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00000254A6 | NRP1 | 24736504 25204970 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000034B6F5 | NRP1 | 25416803 27014911 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS00003CF1AD | NRP1 | 24114198 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00003BBF48 | NRP1 | 25416803 26097868 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000000C73C | NRP1 | 25416803 26823738 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| KCTD9 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBR2 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| FLT1 | NRP1 | 10842181 14525934 23452854 24234451 25348397 | physical association | anti bait coimmunoprecipitation,experimental interaction detection | ComPPI,HPRD,IntAct |
| KDR | NRP1 | 11333271 14525934 16763549 17222790 24234451 25348397 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction | ComPPI,HPRD,IntAct |
| VEGFA | NRP1 | 10409677 11986311 14525934 16763549 17222790 24234451 25348397 9529250 | physical association | anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,cross-linking study,experimental interaction detection,physical interaction,biochemical,enzyme linked immunosorbent assay | ComPPI,HPRD,IntAct |
| VEGFB | NRP1 | 10409677 14525934 25348397 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD |
| FLNA | NRP1 | 24021649 24234451 25348397 27898060 | N/A | isothermal titration calorimetry,surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct,OmniPath |
| PDGFB | NRP1 | 16847823 20577048 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| L1CAM | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| CSNK2A1 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| AGER | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| TNFAIP1 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPL | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| TNF | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| UBR2 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| CSNK2A2 | NRP1 | 23455922 24234451 25348397 | association | physical interaction,tandem affinity purification | ComPPI,IntAct |
| ODF2 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| TGFBR3 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| PIP5K1A | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| IL27RA | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| EDNRB | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| HNRNPD | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| SRRM1 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| ICAM2 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| ITGA5 | NRP1 | 19175293 24234451 25348397 | physical association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| UBR1 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| NSUN2 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| UBR4 | NRP1 | 25348397 | N/A | physical interaction | ComPPI |
| NRP1 | TGFBR1 | 25348397 | N/A | physical interaction | ComPPI |
| NRP1 | RPL27 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| NRP1 | TMEM30A | 25348397 | N/A | physical interaction | ComPPI |
| NRP1 | TMX1 | 25348397 | N/A | physical interaction | ComPPI |
| NRP1 | KCTD10 | 25348397 | N/A | physical interaction | ComPPI |
| NRP1 | SEMA3B | 10196546 14525934 | N/A | experimental interaction detection | HPRD |
| GIPC1 | NRP1 | 10414980 14525934 15978582 27898060 | N/A | experimental interaction detection | HPRD,OmniPath |
| FGF2 | NRP1 | 14525934 15695515 | N/A | experimental interaction detection | HPRD |
| FGF4 | NRP1 | 14525934 15695515 | N/A | experimental interaction detection | HPRD |
| FGF7 | NRP1 | 14525934 15695515 | N/A | experimental interaction detection | HPRD |
| FGF1 | NRP1 | 14525934 15695515 | N/A | experimental interaction detection | HPRD |
| NCL | NRP1 | 24234451 30021884 | physical association | cross-linking study | IntAct |
| L1CAM | NRP1 | 10520994 15121181 27898060 | stimulant | N/A | OmniPath |