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GENE：OPA1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol OPA1
FullNmae OPA1 mitochondrial dynamin like GTPase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8140
EnsembleID ENSG00000198836
Uniprot O60313

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
OPA1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
OPA1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
OPA1 GO:0000002,GO:0000266,GO:0000287,GO:0001843,GO:0003924,GO:0003924,GO:0003924,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005739,GO:0005741,GO:0005743,GO:0005743,GO:0005743,GO:0005758,GO:0005758,GO:0005829,GO:0005874,GO:0006915,GO:0007005,GO:0007005,GO:0007007,GO:0007601,GO:0008017,GO:0008053,GO:0008053,GO:0008053,GO:0008053,GO:0016020,GO:0019896,GO:0030061,GO:0030425,GO:0031966,GO:0043066,GO:0046039,GO:0051259,GO:0070300,GO:0090201,GO:0090398,GO:0097749,GO:1901612,GO:1902236,GO:1904115

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
OPA1 hsa:4976 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
OPA1 hsa:4976 path:hsa05017 Spinocerebellar ataxia - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SMAD2 OPA1 18729074 23180781 physical association tandem affinity purification InnateDB
SMAD3 OPA1 18729074 23180781 physical association tandem affinity purification InnateDB

Source Target Pmid Interactiontype Methods Database
E2F4 OPA1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 OPA1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 OPA1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 OPA1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 OPA1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 OPA1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 OPA1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 OPA1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 OPA1 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00003CF1AD OPA1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EED18 OPA1 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
MCM2 OPA1 25348397 N/A physical interaction ComPPI
SMAD2 OPA1 25348397 N/A physical interaction,tandem affinity purification ComPPI
SMAD3 OPA1 25348397 N/A physical interaction,tandem affinity purification ComPPI
KAT2B OPA1 24234451 24344202 25348397 acetylation reaction enzymatic study ComPPI,IntAct
PTH1R OPA1 25348397 N/A physical interaction ComPPI
CUL3 OPA1 25348397 N/A physical interaction ComPPI
NTRK1 OPA1 25348397 N/A physical interaction ComPPI
MYC OPA1 17353931 21150319 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
PTPN7 OPA1 25348397 N/A physical interaction ComPPI
EPHA1 OPA1 25348397 N/A physical interaction ComPPI
NR4A2 OPA1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
EGFR OPA1 25348397 N/A physical interaction ComPPI
HTRA2 OPA1 25348397 N/A physical interaction ComPPI
MME OPA1 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
PRKN OPA1 25348397 N/A physical interaction ComPPI
CAND1 OPA1 25348397 N/A physical interaction ComPPI
VIPR2 OPA1 25348397 N/A physical interaction ComPPI
BNIP3 OPA1 20436456 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct,OmniPath
ELAVL1 OPA1 25348397 N/A physical interaction ComPPI
EEF2 OPA1 25348397 N/A physical interaction ComPPI
NPTX1 OPA1 25348397 N/A physical interaction ComPPI
XRCC3 OPA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGAP17 OPA1 25348397 N/A physical interaction ComPPI
PRDX3 OPA1 25348397 N/A physical interaction ComPPI
EHD1 OPA1 25348397 N/A physical interaction ComPPI
ILF3 OPA1 25348397 N/A physical interaction ComPPI
ECH1 OPA1 25348397 N/A physical interaction ComPPI
SIRT3 OPA1 24234451 24344202 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
SCGN OPA1 25348397 N/A physical interaction ComPPI
AIFM1 OPA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX4I1 OPA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
PLGRKT OPA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COQ9 OPA1 25348397 N/A physical interaction ComPPI
PTP4A3 OPA1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HADHB OPA1 25348397 N/A physical interaction ComPPI
NDUFS1 OPA1 25348397 N/A physical interaction ComPPI
NPY2R OPA1 25348397 N/A physical interaction ComPPI
APP OPA1 25348397 N/A physical interaction ComPPI
DNASE2 OPA1 25348397 N/A physical interaction ComPPI
NDUFA9 OPA1 25348397 N/A physical interaction ComPPI
SFXN1 OPA1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
COX6B1 OPA1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
GID8 OPA1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
LRRK2 OPA1 24234451 24282027 25348397 colocalization,physical association anti tag coimmunoprecipitation,confocal microscopy ComPPI,IntAct
NDUFS8 OPA1 25348397 N/A physical interaction ComPPI
OPA1 NIT2 25348397 N/A physical interaction ComPPI
OPA1 SCN2B 25348397 N/A physical interaction ComPPI
OPA1 UNK 25348397 N/A physical interaction ComPPI
OPA1 INSYN2A 25348397 N/A physical interaction ComPPI
OPA1 FAM174A 25348397 N/A physical interaction ComPPI
OPA1 SCO1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
MKI67 OPA1 24234451 26949251 association anti tag coimmunoprecipitation IntAct
POU1F1 OPA1 24234451 30021884 physical association cross-linking study IntAct
NPM1 OPA1 24234451 30021884 physical association cross-linking study IntAct

Visualization










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