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GENE：PAK5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PAK5
FullNmae p21 (RAC1) activated kinase 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15916
EnsembleID ENSG00000101349
Uniprot Q9P286

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PAK5 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAK5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAK5 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PAK5 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PAK5 GO:0001558,GO:0004674,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0005886,GO:0006468,GO:0006915,GO:0007010,GO:0007165,GO:0007612,GO:0007613,GO:0007626,GO:0008283,GO:0016310,GO:0016477,GO:0031965,GO:0035556,GO:0043408,GO:0045202,GO:0106310,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PAK5 hsa:57144 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
PAK5 hsa:57144 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
PAK5 hsa:57144 path:hsa04360 Axon guidance - Homo sapiens (human)
PAK5 hsa:57144 path:hsa04510 Focal adhesion - Homo sapiens (human)
PAK5 hsa:57144 path:hsa04660 T cell receptor signaling pathway - Homo sapiens (human)
PAK5 hsa:57144 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
PAK5 hsa:57144 path:hsa05170 Human immunodeficiency virus 1 infection - Homo sapiens (human)
PAK5 hsa:57144 path:hsa05211 Renal cell carcinoma - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FOXP3 PAK5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 PAK5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CTCF PAK5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PAK5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PAK5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PAK5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 PAK5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000260A3A PAK5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D PAK5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000072E4C PAK5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040FA88 PAK5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000040780F PAK5 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 PAK5 25416803 26231038 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PAK5 GATA1 22135298 phosphorylation N/A PhosphoSite
PAK5 TCF3 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
LENG1 PAK5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DDX6 PAK5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GCC1 PAK5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CHCHD2 PAK5 25348397 N/A physical interaction ComPPI
FHL3 PAK5 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ATP5PO PAK5 25348397 N/A physical interaction ComPPI
CATSPER1 PAK5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC42 PAK5 11756552 12032833 14525934 20936779 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo,two hybrid prey pooling approach ComPPI,HPRD,IntAct
SORBS3 PAK5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
LZTS2 PAK5 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ATPAF2 PAK5 24234451 25348397 25416956 25910212 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
EMD PAK5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UXT PAK5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
RAC1 PAK5 11756552 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EXOSC1 PAK5 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
BAD PAK5 10521512 10837486 10880354 12897128 14525934 25348397 9381178 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CSNK1D PAK5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK5 INKA1 24234451 25348397 25416956 physical association two hybrid,physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PAK5 PDLIM7 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PAK5 TUBGCP4 14525934 16189514 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
PAK5 S100A9 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK5 S100A7 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK5 RPA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK5 AP2S1 25348397 N/A physical interaction ComPPI
PAK5 CCDC59 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK5 ARRB2 17620599 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK5 CCNG1 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PAK5 CRBN 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PAK5 CARD9 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PAK5 ARMC7 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PAK5 PAK4 25348397 N/A physical interaction ComPPI
PAK5 MIPEP 25348397 N/A physical interaction ComPPI
PAK5 COA7 25348397 N/A physical interaction ComPPI
PAK5 IDE 25348397 N/A physical interaction ComPPI
PAK5 HTRA2 25348397 N/A physical interaction ComPPI
PAK5 PTPMT1 25348397 N/A physical interaction ComPPI
PAK5 PMPCA 25348397 N/A physical interaction ComPPI
PAK5 XPNPEP3 25348397 N/A physical interaction ComPPI
PAK5 ATP5PD 25348397 N/A physical interaction ComPPI
PAK5 PMPCB 25348397 N/A physical interaction ComPPI
PAK5 CLPB 25348397 N/A physical interaction ComPPI
PAK5 DGLUCY 25348397 N/A physical interaction ComPPI
PAK5 NDUFV1 25348397 N/A physical interaction ComPPI
PAK5 PITRM1 25348397 N/A physical interaction ComPPI
PAK5 OXCT1 25348397 N/A physical interaction ComPPI
PAK5 C1QBP 24234451 25348397 27499296 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PAK5 ARHGEF11 25348397 N/A physical interaction ComPPI
PAK5 CARMIL1 25348397 N/A physical interaction ComPPI
PAK5 ARHGEF2 25348397 N/A physical interaction ComPPI
PAK5 METAP1D 25348397 N/A physical interaction ComPPI
PAK5 TBC1D2B 25348397 N/A physical interaction ComPPI
PAK5 TANC2 25348397 N/A physical interaction ComPPI
PAK5 OBSL1 25348397 N/A physical interaction ComPPI
PAK5 SUPT5H 25348397 N/A physical interaction ComPPI
PAK5 AMZ2 25348397 N/A physical interaction ComPPI
PAK5 FBLN1 25348397 N/A physical interaction ComPPI
PAK5 ZNF598 25348397 N/A physical interaction ComPPI
PAK5 AURKA 25348397 N/A physical interaction ComPPI
PAK5 GMPPA 25348397 N/A physical interaction ComPPI
PAK5 YWHAZ 25348397 N/A physical interaction ComPPI
PAK5 MRPL39 25348397 N/A physical interaction ComPPI
PAK5 PLK1 25348397 N/A physical interaction ComPPI
PAK5 GATD1 25348397 N/A physical interaction ComPPI
PAK5 USP7 25348397 N/A physical interaction ComPPI
PAK5 RBM6 25348397 N/A physical interaction ComPPI
PAK5 UBR2 25348397 N/A physical interaction ComPPI
PAK5 SUPT4H1 25348397 N/A physical interaction ComPPI
PAK5 CCDC138 25348397 N/A physical interaction ComPPI
PAK5 HIGD1A 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PAK5 TSGA10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK5 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK5 ENKD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK5 LNX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK5 ARHGEF19 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK5 RHOJ 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK5 PRPF31 24234451 25348397 25910212 physical association two hybrid,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
PAK5 PTPN21 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PAK5 PHYHIPL 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 SHMT2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 ECHDC1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 OXCT2 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 NFS1 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 MICOS13 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 BCKDHA 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 NME4 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 SLC25A5 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
POLDIP2 PAK5 25348397 N/A physical interaction ComPPI
PKM PAK5 25348397 N/A protein kinase assay ComPPI
TTC19 PAK5 25348397 N/A physical interaction ComPPI
PSMF1 PAK5 19060904 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach ComPPI,IntAct
ECH1 PAK5 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PAK5 PAK5 11756552 14525934 N/A experimental interaction detection HPRD
PAK5 TCF3 26212009 27898060 N/A N/A OmniPath
PAK5 GATA1 25726523 27898060 N/A N/A OmniPath
PAK5 CTNND1 18220336 18669648 20564219 27898060 N/A N/A OmniPath
PAK5 BAD 10521512 10837486 10880354 12897128 27898060 9381178 N/A N/A OmniPath
PAK5 RNF7 12748192 27898060 N/A N/A OmniPath

Visualization










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