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GENE：PARP2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PARP2
FullNmae poly(ADP-ribose) polymerase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:272
EnsembleID ENSG00000129484
Uniprot Q9UGN5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PARP2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PARP2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PARP2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PARP2 GO:0003682,GO:0003684,GO:0003950,GO:0003950,GO:0005515,GO:0005634,GO:0005654,GO:0005730,GO:0005730,GO:0006281,GO:0006284,GO:0006302,GO:0006974,GO:0016779,GO:0030592,GO:0031491,GO:0046697,GO:0061051,GO:0070212,GO:0070212,GO:0070213,GO:0072572,GO:0090649,GO:0090734,GO:0097191,GO:0110088,GO:0140294,GO:0140805,GO:0140806,GO:0140807,GO:0140861,GO:0160004,GO:1990404,GO:1990404

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PARP2 hsa:10038 path:hsa03410 Base excision repair - Homo sapiens (human)
PARP2 hsa:10038 path:hsa04210 Apoptosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
BRCA1 PARP2 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 26192618 9721205 interaction type N/A ACSN
MRE11 PARP2 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 26192618 9721205 interaction type N/A ACSN
PARP1 PARP2 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 18835851 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21037379 21060331 21076181 21270334 21337561 21376743 21818122 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 26192618 9721205 association N/A ACSN
RAD50 PARP2 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 26192618 9721205 interaction type N/A ACSN
PARP2 POLB 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 26192618 8264637 8978692 interaction type N/A ACSN
WRN PARP2 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 26192618 8264637 8978692 interaction type N/A ACSN
XRCC1 PARP2 10858306 11163244 11283614 11948190 12032095 12202749 12637553 14726013 15385537 15385968 15703371 16442856 16449207 16697054 17055429 17116323 17638872 17965729 18398454 18524993 18558713 18584027 18809224 19208614 19490890 19546231 196269035 19748837 19847258 20027199 20064462 20211143 20227374 20510258 20603072 20691907 20713526 21251944 21376743 2191300 22055391 22469522 22657828 22713970 22743550 22921416 23082994 23161013 23253856 24036544 24050180 24709898 26192618 8264637 8978692 interaction type N/A ACSN
PARG PARP2 196269035 22469522 22713970 23110147 24684389 26192618 interaction type N/A ACSN
ATR PARP2 11438669 11877377 14988723 15136767 15459660 15485915 15798197 15867354 16332722 16540648 16713580 16731533 16885023 17102137 17116885 17296725 17303408 17384638 17582221 18048416 18511906 18543256 18677104 18716619 18756267 18931676 18995830 19004803 19282663 19357644 19490890 19622404 19686080 19772495 19788416 19793801 19793861 19841479 20019063 20051983 26192618 9488723 9858600 interaction type N/A ACSN
ATM PARP2 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 26192618 9168117 9858600 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
E2F4 PARP2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PARP2 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 PARP2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PARP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PARP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PARP2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC PARP2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004CD810 PARP2 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075A608 PARP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 PARP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005CCD18 PARP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B PARP2 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AD2AA PARP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004214BB PARP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 PARP2 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 PARP2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PARP2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000C4DB5 PARP2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 PARP2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00003D4175 PARP2 20371350 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004F2EB0 PARP2 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001E0AEA PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000759B6A PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000171020 PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000020579D PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000913AC PARP2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000355E82 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001C0099 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027352D PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00001925C1 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB35 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000031BC7D PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000031D186 PARP2 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000CBE63 PARP2 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
VPS37C PARP2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
TFAP4 PARP2 25348397 N/A physical interaction ComPPI
HSPA2 PARP2 25348397 N/A physical interaction ComPPI
POLB PARP2 25348397 N/A physical interaction ComPPI
NCALD PARP2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
TNP2 PARP2 25348397 N/A physical interaction ComPPI
FOXB1 PARP2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
H2BC4 PARP2 25348397 N/A physical interaction ComPPI
AIM2 PARP2 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
APLF PARP2 21812934 24234451 25348397 adp ribosylation reaction protein array,physical interaction ComPPI,IntAct
STAC PARP2 21812934 24234451 25348397 adp ribosylation reaction protein array,enzymatic study ComPPI,IntAct
CD44 PARP2 25348397 N/A physical interaction ComPPI
DDX20 PARP2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
SDC2 PARP2 25348397 N/A physical interaction ComPPI
GNAQ PARP2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP1 PARP2 12217960 14525934 19629035 24234451 25348397 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
XRCC1 PARP2 11948190 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BUB3 PARP2 12217960 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PARP2 CASP8 12065591 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
PARP2 CENPA 12217960 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PARP2 CENPB 12217960 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PARP2 CHD1L 25348397 N/A anti tag coimmunoprecipitation,physical interaction,physical interaction ComPPI
PARP2 TRIM28 25348397 N/A physical interaction ComPPI
PARP2 RNF146 25348397 N/A physical interaction ComPPI
PARP2 UHRF1 25348397 N/A physical interaction ComPPI
PARP2 RPA4 25348397 N/A physical interaction ComPPI
PARP2 SPIN2B 25348397 N/A physical interaction ComPPI
PARP2 RPA2 25348397 N/A physical interaction ComPPI
PARP2 SIRT6 25348397 N/A physical interaction ComPPI
PARP2 H2BC1 25348397 N/A physical interaction ComPPI
PARP2 H2BC11 25348397 N/A physical interaction ComPPI
PARP2 MSH6 25348397 N/A physical interaction ComPPI
PARP2 HDAC1 25348397 N/A physical interaction ComPPI
PARP2 HPF1 25348397 N/A physical interaction ComPPI
PARP2 H3-4 25348397 N/A physical interaction ComPPI
PARP2 H1-5 25348397 N/A physical interaction ComPPI
PARP2 H1-0 25348397 N/A physical interaction ComPPI
PARP2 H2AX 25348397 N/A physical interaction ComPPI
PARP2 XPC 25348397 N/A physical interaction ComPPI
PARP2 XRCC6 25348397 N/A physical interaction ComPPI
PARP2 MACROD1 25348397 N/A physical interaction ComPPI
PARP2 HMGN2 21812934 24234451 25348397 adp ribosylation reaction protein array,physical interaction ComPPI,IntAct
PARP2 NAA40 25348397 N/A physical interaction ComPPI
PARP2 WDR76 25348397 N/A physical interaction ComPPI
PARP2 CDX1 25348397 N/A physical interaction ComPPI
PARP2 ZNF428 25348397 N/A physical interaction ComPPI
PARP2 MACROH2A2 25348397 N/A physical interaction ComPPI
PARP2 SDC1 25348397 N/A physical interaction ComPPI
PARP2 LHX9 25348397 N/A physical interaction ComPPI
PARP2 VSX2 25348397 N/A physical interaction ComPPI
PARP2 FOXA1 25348397 N/A physical interaction ComPPI
PARP2 FKBP3 21812934 24234451 25348397 adp ribosylation reaction protein array,enzymatic study ComPPI,IntAct
PARP2 ANKS6 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 CERT1 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 DIDO1 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 PRICKLE2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 CHRDL1 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 HAUS6 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 ING5 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 GRAMD1C 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 PTMS 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 UTP15 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 TMEM59 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 LAS2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 TPK1 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 PRSS21 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 ZNF747 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 DIPK1A 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 TM2D2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 CDCA7 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 IL21 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 KDELR2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 FHIP2A 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 CTNNB1 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 NDUFA4 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 AGO1 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 FAM168B 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 HABP2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 CT55 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 IFNA16 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 DFFB 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 ZNF321P 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 ZHX2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 OR4D6 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 PPP4R4 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 CCDC107 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 ERC1 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 RTN3 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 CCDC33 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 MYO1D 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 SLC35F6 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 SYNJ2 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 CD58 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 TMEM159 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 PCCA 21812934 24234451 25348397 adp ribosylation reaction protein array ComPPI,IntAct
PARP2 H1-4 21812934 24234451 25348397 adp ribosylation reaction enzymatic study ComPPI,IntAct
PARP2 PYHIN1 24234451 25348397 25665578 association anti tag coimmunoprecipitation ComPPI,IntAct
CBX5 PARP2 25348397 N/A physical interaction ComPPI
H3C1 PARP2 25348397 N/A physical interaction ComPPI
H3-3A PARP2 25348397 N/A physical interaction ComPPI
CETN1 PARP2 25348397 N/A physical interaction ComPPI

Visualization










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