Gene Information gene info

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GENE：PDCD6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDCD6
FullNmae programmed cell death 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8765
EnsembleID ENSG00000249915
Uniprot O75340

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDCD6 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDCD6 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PDCD6 GO:0000287,GO:0001525,GO:0001938,GO:0005509,GO:0005509,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005768,GO:0005783,GO:0005789,GO:0005829,GO:0006886,GO:0006888,GO:0010595,GO:0014029,GO:0014032,GO:0030127,GO:0030674,GO:0030948,GO:0031410,GO:0031463,GO:0032007,GO:0034605,GO:0036324,GO:0042802,GO:0042803,GO:0043280,GO:0043495,GO:0045766,GO:0046983,GO:0048208,GO:0048306,GO:0051592,GO:0051898,GO:0070062,GO:0070971,GO:0070971,GO:0097190,GO:1902527,GO:1990756

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ANXA11 PDCD6 23180781 25416956 physical association two hybrid InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 PDCD6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PDCD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PDCD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDCD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDCD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PDCD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDCD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PDCD6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000345DEB PDCD6 20602797 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS000035CC3E PDCD6 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
GOLGA2 PDCD6 17196169 24234451 25348397 colocalization confocal microscopy ComPPI,IntAct
VPS37C PDCD6 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CUL5 PDCD6 25348397 N/A physical interaction ComPPI
SMARCE1 PDCD6 25348397 N/A physical interaction ComPPI
MAPK1IP1L PDCD6 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
TSNAX PDCD6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
SH3KBP1 PDCD6 10858458 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
BAG3 PDCD6 25348397 N/A physical interaction ComPPI
PCBP1 PDCD6 25348397 N/A physical interaction ComPPI
SMARCC1 PDCD6 25348397 N/A physical interaction ComPPI
MAGEA1 PDCD6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VCP PDCD6 25348397 N/A physical interaction ComPPI
GABARAPL2 PDCD6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
MCM2 PDCD6 25348397 N/A physical interaction ComPPI
TNIP1 PDCD6 25348397 N/A physical interaction ComPPI
MAP1LC3B PDCD6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
PEF1 PDCD6 11278427 14525934 16189514 21516116 21988832 24234451 25348397 25416956 26344197 27898060 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct,OmniPath
HNRNPH2 PDCD6 25348397 N/A physical interaction ComPPI
MYH7 PDCD6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NF2 PDCD6 25348397 N/A physical interaction ComPPI
CRKL PDCD6 25348397 N/A physical interaction ComPPI
KDR PDCD6 21893193 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid ComPPI,IntAct,OmniPath
GRB2 PDCD6 12577067 24234451 25348397 association pull down ComPPI,IntAct
SMARCD1 PDCD6 25348397 N/A physical interaction ComPPI
CPNE1 PDCD6 12522145 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CPNE2 PDCD6 12522145 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
CPNE4 PDCD6 12522145 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
CUL3 PDCD6 25348397 N/A physical interaction ComPPI
YWHAZ PDCD6 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
CDKN2A PDCD6 17955473 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
UBC PDCD6 25348397 N/A physical interaction ComPPI
ARFIP1 PDCD6 25348397 N/A physical interaction ComPPI
MAP3K5 PDCD6 12372597 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MYC PDCD6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPU PDCD6 25348397 N/A physical interaction ComPPI
PABPC4 PDCD6 25348397 N/A physical interaction ComPPI
TXN PDCD6 25348397 N/A physical interaction ComPPI
CFTR PDCD6 17110338 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ARID1B PDCD6 25348397 N/A physical interaction ComPPI
PLSCR3 PDCD6 18256029 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,far western blotting,pull down,surface plasmon resonance,enzyme linked immunosorbent assay ComPPI,IntAct
PABPC1 PDCD6 25348397 N/A physical interaction ComPPI
ABCB7 PDCD6 25348397 N/A physical interaction ComPPI
XPO1 PDCD6 25348397 N/A physical interaction ComPPI
YWHAQ PDCD6 25348397 N/A physical interaction ComPPI
SMARCB1 PDCD6 25348397 N/A physical interaction ComPPI
CSK PDCD6 25348397 N/A physical interaction ComPPI
CUL2 PDCD6 25348397 N/A physical interaction ComPPI
ANXA11 PDCD6 11883939 14525934 18256029 24234451 25348397 25910212 physical association two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,in vitro,two hybrid bait and prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
CUL1 PDCD6 25348397 N/A physical interaction ComPPI
FASLG PDCD6 11606059 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
ANXA2 PDCD6 25348397 N/A physical interaction ComPPI
DROSHA PDCD6 25348397 N/A physical interaction ComPPI
FUBP1 PDCD6 25348397 N/A physical interaction ComPPI
CCNB1 PDCD6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP1LC3A PDCD6 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
HSPA9 PDCD6 25348397 N/A physical interaction ComPPI
TSG101 PDCD6 18256029 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
AURKA PDCD6 25348397 N/A physical interaction ComPPI
BAG4 PDCD6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VCAM1 PDCD6 19738201 22623428 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
ITGA4 PDCD6 25348397 N/A physical interaction ComPPI
IGBP1 PDCD6 25348397 N/A physical interaction ComPPI
RAB1B PDCD6 25348397 N/A physical interaction ComPPI
CAND1 PDCD6 25348397 N/A physical interaction ComPPI
HNRNPUL1 PDCD6 25348397 N/A physical interaction ComPPI
PDCD6 TIMM22 11591653 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PDCD6 PDCD6IP 10200558 11883939 12034747 14525934 14999017 17196169 18256029 18940611 19143629 23924735 24234451 25348397 27898060 9880530 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,far western blotting,pull down,x-ray crystallography,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
PDCD6 HEBP2 14525934 16189514 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,validated two hybrid,two hybrid ComPPI,HPRD,IntAct
PDCD6 FAS 11606059 14525934 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
PDCD6 H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDCD6 GCN1 25348397 N/A physical interaction ComPPI
PDCD6 IKBIP 25348397 N/A physical interaction ComPPI
PDCD6 ERLIN2 25348397 N/A physical interaction ComPPI
PDCD6 FN1 25348397 N/A physical interaction ComPPI
PDCD6 CDKN2A 25348397 N/A physical interaction ComPPI
PDCD6 DDX1 25348397 N/A physical interaction ComPPI
PDCD6 FLII 25348397 N/A physical interaction ComPPI
PDCD6 MAP4 25348397 N/A physical interaction ComPPI
PDCD6 NMT1 25348397 N/A physical interaction ComPPI
PDCD6 HAUS2 25348397 N/A physical interaction ComPPI
PDCD6 TP53 25348397 N/A physical interaction ComPPI
PDCD6 DAPK1 16132846 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct,OmniPath
PDCD6 MOV10 25348397 N/A physical interaction ComPPI
PDCD6 NXF1 25348397 N/A physical interaction ComPPI
PDCD6 HNRNPUL2 25348397 N/A physical interaction ComPPI
PDCD6 IGF2BP3 25348397 N/A physical interaction ComPPI
PDCD6 ITPA 25348397 N/A physical interaction ComPPI
PDCD6 AKR1A1 25348397 N/A physical interaction ComPPI
PDCD6 ANXA2P2 25348397 N/A physical interaction ComPPI
PDCD6 ANXA5 25348397 N/A physical interaction ComPPI
PDCD6 CLIC4 25348397 N/A physical interaction ComPPI
PDCD6 CSTB 25348397 N/A physical interaction ComPPI
PDCD6 HNRNPH1 25348397 N/A physical interaction ComPPI
PDCD6 HNRNPH3 25348397 N/A physical interaction ComPPI
PDCD6 IMPA2 25348397 N/A physical interaction ComPPI
PDCD6 LMAN1 25348397 N/A physical interaction ComPPI
PDCD6 MRPL37 25348397 N/A physical interaction ComPPI
PDCD6 NUDT13 25348397 N/A physical interaction ComPPI
PDCD6 QDPR 25348397 N/A physical interaction ComPPI
PDCD6 RAB1C 25348397 N/A physical interaction ComPPI
PDCD6 SEPHS1 25348397 N/A physical interaction ComPPI
PDCD6 TARDBP 25348397 N/A physical interaction ComPPI
PDCD6 TKT 25348397 N/A physical interaction ComPPI
PDCD6 TYMS 25348397 N/A physical interaction ComPPI
PDCD6 UBQLN1 25348397 N/A physical interaction ComPPI
PDCD6 SAR1B 25348397 N/A physical interaction ComPPI
PDCD6 GFUS 25348397 N/A physical interaction ComPPI
PDCD6 MED4 25348397 N/A physical interaction ComPPI
PDCD6 MED20 25348397 N/A physical interaction ComPPI
PDCD6 CCNA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDCD6 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDCD6 MYH7B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDCD6 FERMT3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDCD6 SAMD1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDCD6 TRIM25 25348397 N/A physical interaction ComPPI
PDCD6 KLHL12 25348397 N/A physical interaction ComPPI
PDCD6 SEC31A 16957052 17196169 18256029 20834162 24234451 25348397 27898060 colocalization,physical association far western blotting,pull down,physical interaction,confocal microscopy ComPPI,IntAct,OmniPath
PDCD6 SEC13 25348397 N/A physical interaction ComPPI
PDCD6 SEC16A 25348397 N/A physical interaction ComPPI
PDCD6 SEC23A 25348397 N/A physical interaction ComPPI
PDCD6 SEC23IP 17196169 24234451 25348397 colocalization pull down,physical interaction,confocal microscopy ComPPI,IntAct
PDCD6 P4HA1 25348397 N/A physical interaction ComPPI
PDCD6 DPF2 25348397 N/A physical interaction ComPPI
PDCD6 TFG 25348397 N/A physical interaction ComPPI
PDCD6 KCTD15 25348397 N/A physical interaction ComPPI
PDCD6 NFKB1 25348397 N/A physical interaction ComPPI
PDCD6 ARID1A 25348397 N/A physical interaction ComPPI
PDCD6 CHERP 22437941 24078636 25348397 27898060 N/A physical interaction ComPPI,OmniPath
PDCD6 MVB12A 25348397 N/A physical interaction ComPPI
PDCD6 SMARCC2 25348397 N/A physical interaction ComPPI
PDCD6 SMARCA2 25348397 N/A physical interaction ComPPI
PDCD6 SEC24B 25348397 N/A physical interaction ComPPI
PDCD6 DCTN2 24234451 25348397 26950892 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDCD6 PLSCR4 18256029 24234451 25348397 physical association pull down ComPPI,IntAct
PDCD6 ANXA7 12445460 14525934 18256029 24234451 25348397 physical association experimental interaction detection,pull down ComPPI,HPRD,IntAct
PDCD6 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
PDCD6 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
MIF PDCD6 25348397 N/A physical interaction ComPPI
PTPN23 PDCD6 17174262 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid ComPPI,IntAct
DUSP21 PDCD6 25348397 N/A physical interaction ComPPI
IGFALS PDCD6 11591653 14525934 N/A experimental interaction detection HPRD
PDCD6 PDCD6 14525934 16189514 18940611 21988832 24234451 25416956 physical association two hybrid,x-ray crystallography,two hybrid array,two hybrid pooling approach,two hybrid HPRD,IntAct

Source Target Pmid Interactiontype Methods Database
URS00009C29B8 PDCD6 27087310 direct interaction,inhibition N/A NPInter

Visualization










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