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GENE：PDK2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PDK2
FullNmae pyruvate dehydrogenase kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8810
EnsembleID ENSG00000005882
Uniprot Q15119

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PDK2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PDK2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PDK2 GO:0004672,GO:0004740,GO:0004740,GO:0004740,GO:0005515,GO:0005524,GO:0005654,GO:0005739,GO:0005739,GO:0005759,GO:0005829,GO:0005967,GO:0006006,GO:0006111,GO:0006468,GO:0006885,GO:0008286,GO:0010510,GO:0010510,GO:0010565,GO:0010906,GO:0010906,GO:0016310,GO:0031670,GO:0034614,GO:0042593,GO:0042803,GO:0050848,GO:0072332

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PDK2 hsa:5164 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PDK2 DLD 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
HTT PDK2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 PDK2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 PDK2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PDK2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF PDK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PDK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PDK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PDK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PDK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PDK2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARG PDK2 15955060 trascriptional regulation,stimulation inferred by curator TFlink
MYC PDK2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000C85B2 PDK2 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PDK2 PDHA1 22135298 phosphorylation N/A PhosphoSite
PDK2 PDHA2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
STAT5A PDK2 25348397 N/A physical interaction ComPPI
FECH PDK2 25348397 N/A physical interaction ComPPI
PDHB PDK2 25348397 N/A physical interaction ComPPI
PDHX PDK2 12573248 12816949 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDHA1 PDK2 11485553 11486000 12676647 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
HTT PDK2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CTTN PDK2 17707375 24234451 25348397 colocalization cosedimentation,cosedimentation in solution ComPPI,IntAct
PDK2 PDK1 12573248 14525934 24234451 25348397 26496610 29568061 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
PDK2 DLAT 12816949 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDK2 SGK1 10191262 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PDK2 AKT1 10438924 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PDK2 HIC2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDK2 ISOC2 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
PDK2 VSIG4 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PDK2 ADCK2 25348397 N/A physical interaction ComPPI
PDK2 FOXD4 25348397 N/A physical interaction ComPPI
PDK2 PDK3 25348397 N/A physical interaction ComPPI
PDK2 PDK4 25348397 N/A physical interaction ComPPI
PDK2 SYT12 25348397 N/A physical interaction ComPPI
PDK2 ACAD9 25348397 N/A physical interaction ComPPI
PDK2 COQ8A 24234451 25348397 27499296 association anti tag coimmunoprecipitation ComPPI,IntAct
PDK2 PDK2 11483605 11978179 12816949 14525934 N/A experimental interaction detection HPRD
PDK2 AKT1 10438924 16341064 27898060 stimulant N/A OmniPath
PDK2 PDHA2 16436377 27898060 inhibition N/A OmniPath
PDK2 PDHA1 11485553 11486000 12676647 16436377 17474719 18212344 18691976 18767875 19415658 20166139 27898060 inhibition N/A OmniPath

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