GENE：PDX1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | PDX1 |
| FullNmae | pancreatic and duodenal homeobox 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:6107 |
| EnsembleID | ENSG00000139515 |
| Uniprot | P52945 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| PDX1 | apoptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| PDX1 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| PDX1 | GO:0000122,GO:0000785,GO:0000978,GO:0000981,GO:0000981,GO:0001889,GO:0003309,GO:0003309,GO:0003309,GO:0003700,GO:0005634,GO:0005654,GO:0005829,GO:0006006,GO:0006091,GO:0006357,GO:0006366,GO:0007224,GO:0007263,GO:0009410,GO:0009887,GO:0010040,GO:0010157,GO:0010255,GO:0016331,GO:0016607,GO:0030073,GO:0031017,GO:0031100,GO:0032024,GO:0033273,GO:0034097,GO:0035094,GO:0035774,GO:0043201,GO:0043279,GO:0044342,GO:0045944,GO:0048565,GO:0048863,GO:0050680,GO:0051384,GO:0060290,GO:0070059,GO:0070542,GO:0097050,GO:1902236,GO:1904692,GO:1990837,GO:1990841,GO:2000675 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| PDX1 | hsa:3651 | path:hsa04911 | Insulin secretion - Homo sapiens (human) |
| PDX1 | hsa:3651 | path:hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| PDX1 | hsa:3651 | path:hsa04950 | Maturity onset diabetes of the young - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PDX1 | PDX1 | 11590182 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HNF1A | PDX1 | 11590182 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| KLF11 | PDX1 | 19843526 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| PRDM14 | PDX1 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| ATF6 | PDX1 | 18450959 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SREBF1 | PDX1 | 16091421 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF2 | PDX1 | 10393088 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| USF1 | PDX1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKDC | PDX1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK14 | PDX1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK1 | PDX1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| MAPK9 | PDX1 | 22135298 | phosphorylation | N/A | PhosphoSite |
| PDX1 | CREB1 | 25361965 | interaction type | N/A | PTMCode2 |
| CREB1 | PDX1 | 25361965 | interaction type | N/A | PTMCode2 |
| SPOP | PDX1 | 25361965 | interaction type | N/A | PTMCode2 |
| PDX1 | SPOP | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| PRKDC | PDX1 | 25348397 | N/A | physical interaction | ComPPI |
| ATF3 | PDX1 | 21986529 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| MAPK14 | PDX1 | 25348397 | N/A | physical interaction | ComPPI |
| XRCC5 | PDX1 | 25348397 | N/A | physical interaction | ComPPI |
| XRCC6 | PDX1 | 25348397 | N/A | physical interaction | ComPPI |
| PDX1 | NEUROD1 | 10636926 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PDX1 | SPOP | 14525934 15121856 25348397 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| PDX1 | CREB1 | 14525934 25348397 27898060 7505393 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| PDX1 | PCIF1 | 14525934 17126328 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| PDX1 | SLC2A2 | 14525934 25348397 27898060 8923459 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| PDX1 | TCF3 | 10636926 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PDX1 | IAPP | 14525934 25348397 27898060 9115263 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| PDX1 | MAFA | 14525934 15664999 15665000 25348397 27898060 | N/A | experimental interaction detection,physical interaction | ComPPI,HPRD,OmniPath |
| PDX1 | ALK | 25348397 | N/A | physical interaction | ComPPI |
| PDX1 | PBX1 | 25348397 27898060 8524276 | N/A | physical interaction | ComPPI,OmniPath |
| PDX1 | PASK | 21418524 24234451 25348397 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct |
| PDX1 | PDX1 | 14525934 15664999 15665000 | N/A | experimental interaction detection | HPRD |
| HIPK2 | PDX1 | 20637728 27898060 | N/A | N/A | OmniPath |
| PRKDC | PDX1 | 16166097 27898060 | N/A | N/A | OmniPath |