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GENE：PELI3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PELI3
FullNmae pellino E3 ubiquitin protein ligase family member 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:30010
EnsembleID ENSG00000174516
Uniprot Q8N2H9

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PELI3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PELI3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PELI3 GO:0005515,GO:0005829,GO:0008592,GO:0010804,GO:0016567,GO:0045087,GO:0061630,GO:0070534,GO:2001237

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PELI3 IRAK1 17997719 19081057 23180781 phosphorylation reaction,physical association pull down,protein kinase assay InnateDB
PELI3 RIPK2 23180781 23892723 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CTCF PELI3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PELI3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002CEB74 PELI3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 PELI3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 PELI3 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PELI3 IRAK4 25361965 interaction type N/A PTMCode2
IRAK4 PELI3 25361965 interaction type N/A PTMCode2
PELI3 IRAK1 25361965 interaction type N/A PTMCode2
IRAK1 PELI3 25361965 interaction type N/A PTMCode2
TRAF6 PELI3 25361965 interaction type N/A PTMCode2
PELI3 TRAF6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TRAF6 PELI3 12874243 14525934 23042151 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PIK3R3 PELI3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
UBE2N PELI3 25348397 N/A physical interaction ComPPI
IRAK1 PELI3 12874243 14525934 16884718 17675297 18326498 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
IRAK2 PELI3 14525934 17675297 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RIPK2 PELI3 25348397 N/A physical interaction ComPPI
MAP3K14 PELI3 12874243 14525934 25348397 N/A anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
MAP3K7 PELI3 12874243 14525934 25348397 N/A anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
IRAK4 PELI3 14525934 17675297 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PELI3 APP 25348397 N/A physical interaction ComPPI
PELI3 UBE2V1 25348397 N/A physical interaction ComPPI
PELI3 UQCRFS1 25348397 N/A physical interaction ComPPI
PELI3 KANK2 25348397 N/A physical interaction ComPPI
PELI3 STUB1 25348397 N/A physical interaction ComPPI
PELI3 DNAJB4 25348397 N/A physical interaction ComPPI
SQSTM1 PELI3 25483963 27898060 N/A N/A OmniPath
PELI3 RIPK2 23892723 27898060 N/A N/A OmniPath
IRAK1 PELI3 12874243 15917247 16884718 17675297 17997719 18326498 19081057 25027698 27898060 stimulant N/A OmniPath
PELI3 IRAK1 12874243 15917247 16884718 17675297 17997719 18326498 19081057 25027698 27898060 stimulant N/A OmniPath

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