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GENE：PERP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PERP
FullNmae p53 apoptosis effector related to PMP22
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17637
EnsembleID ENSG00000112378
Uniprot Q96FX8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PERP apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PERP apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PERP GO:0002934,GO:0005515,GO:0005739,GO:0005794,GO:0005886,GO:0005911,GO:0007219,GO:0030057,GO:0034113,GO:0045862,GO:0072332,GO:0097186,GO:0097202,GO:0098609

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PERP hsa:64065 path:hsa04115 p53 signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA2 PERP 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 PERP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PERP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PERP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PERP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PERP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A PERP 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PERP 15856024 17344317 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 PERP 16822819 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000F31F4 PERP 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00002F3336 PERP 23313552 23807165 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS0000204177 PERP 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000458AD2 PERP 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002EF20A PERP 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 PERP 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000057FDB8 PERP 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 PERP 20371350 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 PERP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 PERP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 PERP 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000048B5E9 PERP 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TRIM25 PERP 25348397 N/A physical interaction ComPPI
MAL PERP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TP53 PERP 18431400 27898060 stimulant N/A OmniPath

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