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GENE：PF4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PF4
FullNmae platelet factor 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8861
EnsembleID ENSG00000163737
Uniprot P02776

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PF4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PF4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PF4 GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005737,GO:0006954,GO:0007189,GO:0008009,GO:0008009,GO:0008201,GO:0010628,GO:0010744,GO:0016525,GO:0019221,GO:0030168,GO:0030593,GO:0030595,GO:0031093,GO:0032760,GO:0042127,GO:0042832,GO:0045236,GO:0045347,GO:0045651,GO:0045653,GO:0045944,GO:0048248,GO:0051873,GO:0061844,GO:0061844,GO:0062023,GO:0070098,GO:0071222,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PF4 hsa:5196 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
PF4 hsa:5196 path:hsa04061 Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
PF4 hsa:5196 path:hsa04062 Chemokine signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CXCL8 PF4 12586630 23180781 physical association nuclear magnetic resonance,surface plasmon resonance InnateDB
PF4 ACKR1 23180781 8132497 physical association competition binding InnateDB
PF4 VCAN 11083865 23180781 physical association solid phase assay InnateDB
PITX3 PF4 22278372 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR PF4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA3 PF4 19559773 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TIAL1 PF4 9207209 trascriptional regulation,stimulation inferred by curator,electrophoretic mobility shift assay TFlink
SMARCA4 PF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 PF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 PF4 12609849 23848403 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 PF4 23848403 trascriptional regulation,stimulation inferred by curator TFlink
GATA1 PF4 12609849 trascriptional regulation,stimulation inferred by curator TFlink
MEIS1 PF4 12609849 12732210 trascriptional regulation,stimulation inferred by curator TFlink
PBX1 PF4 12609849 trascriptional regulation,stimulation inferred by curator TFlink
PBX2 PF4 12609849 trascriptional regulation,stimulation inferred by curator TFlink
PKNOX1 PF4 12732210 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 PF4 17150917 21129147 23848403 trascriptional regulation,stimulation inferred by curator TFlink
USF1 PF4 15187018 trascriptional regulation,stimulation inferred by curator TFlink
USF2 PF4 15187018 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00002CE0C6 PF4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002C02E4 PF4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000118224 PF4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000008AA34 PF4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000043D2C1 PF4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000015188E PF4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004B83FE PF4 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FGF2 PF4 25361965 interaction type N/A PTMCode2
PF4 FGF2 25361965 interaction type N/A PTMCode2
CCL5 PF4 25361965 interaction type N/A PTMCode2
PF4 CCL5 25361965 interaction type N/A PTMCode2
PF4 CXCR3 25361965 interaction type N/A PTMCode2
CXCR3 PF4 25361965 interaction type N/A PTMCode2
PF4 THBD 25361965 interaction type N/A PTMCode2
THBD PF4 25361965 interaction type N/A PTMCode2
PROC PF4 25361965 interaction type N/A PTMCode2
PF4 PROC 25361965 interaction type N/A PTMCode2
SRGN PF4 25361965 interaction type N/A PTMCode2
PF4 SRGN 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SRGN PF4 14525934 25348397 8613703 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CXCL9 PF4 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
SDC2 PF4 14525934 25348397 27898060 7524669 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
PROC PF4 14525934 25348397 9395524 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PF4 THBD 14525934 25348397 9395524 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PF4 CXCR3 25348397 N/A physical interaction,in vitro ComPPI
PF4 LDLR 11986215 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
PF4 CCL5 14525934 15459010 24234451 25348397 28381538 N/A experimental interaction detection,filter binding,surface plasmon resonance,in vitro,surface plasmon resonance array ComPPI,HPRD,IntAct
PF4 CXCL8 12586630 14525934 15531763 24234451 25348397 28381538 N/A experimental interaction detection,filter binding,surface plasmon resonance,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
PF4 FGF2 14525934 25348397 9558385 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PF4 CXCL12 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,physical interaction,surface plasmon resonance array ComPPI,IntAct
PF4 VCAN 25348397 N/A physical interaction ComPPI
PF4 PLEK 19722192 24234451 25348397 association anti bait coimmunoprecipitation,pull down ComPPI,IntAct
PF4 TNFAIP6 24234451 25348397 27044744 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 APOH 19805618 24234451 25348397 association,physical association affinity chromatography technology ComPPI,IntAct
PF4 CXCL17 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CXCL10 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CXCL6 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CXCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 XCL1 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL28 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL26 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL25 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL21 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL20 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL17 24234451 25348397 28381538 N/A surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL13 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL11 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 CCL2 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
CXCL11 PF4 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
XCL2 PF4 24234451 25348397 28381538 N/A filter binding ComPPI,IntAct
CXCL14 PF4 24234451 25348397 28381538 N/A filter binding,surface plasmon resonance,surface plasmon resonance array ComPPI,IntAct
PF4 PF4 14525934 24234451 28381538 7547867 8031770 N/A experimental interaction detection,surface plasmon resonance HPRD,IntAct
PF4 CXCL8 12586630 15531763 27898060 inhibition N/A OmniPath
PF4 CXCR3 12782716 24218476 27898060 stimulant N/A OmniPath
PF4 VCAN 11083865 27898060 N/A N/A OmniPath
VCAN PF4 11083865 27898060 N/A N/A OmniPath
PF4 ACKR1 27898060 8132497 N/A N/A OmniPath
PF4 THBD 27898060 9395524 stimulant N/A OmniPath

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