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GENE：PHLDA3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PHLDA3
FullNmae pleckstrin homology like domain family A member 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:8934
EnsembleID ENSG00000174307
Uniprot Q9Y5J5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PHLDA3 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PHLDA3 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PHLDA3 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
PHLDA3 GO:0005546,GO:0005547,GO:0005737,GO:0005886,GO:0005886,GO:0009653,GO:0010314,GO:0032266,GO:0042771,GO:0042771,GO:0043065,GO:0043065,GO:0043325,GO:0051898,GO:0051898,GO:0080025

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR PHLDA3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 PHLDA3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 PHLDA3 21245298 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 PHLDA3 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004E008F PHLDA3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BD6DC PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009EA8F PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E728C PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000ECE9C PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E02F2 PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000247AC6 PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006FDD4 PHLDA3 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005586D0 PHLDA3 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 PHLDA3 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS0000221168 PHLDA3 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E PHLDA3 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC PHLDA3 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C PHLDA3 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 PHLDA3 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000EEF5F PHLDA3 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD PHLDA3 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00000CF1D2 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00002CBC6D PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5969 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000036AFF1 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D5FFC PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F0C23 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003EB4CF PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003B59DF PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005D986D PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000038446A PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000032835F PHLDA3 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003003B4 PHLDA3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000435A77 PHLDA3 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000002103A PHLDA3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005FDE70 PHLDA3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000105D19 PHLDA3 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DYNLL1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TMEM11 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NME3 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TOMM22 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SNRPF PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DPM1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MCM5 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TRIO PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NTRK1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RFC2 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DNAJA3 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
XPO5 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DDX5 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
QARS1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDK2 PHLDA3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CUL4A PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
VAMP7 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MMS19 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
GNL3 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IGBP1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
BAZ1B PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IDH3B PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SSR4 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SSR3 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LRPPRC PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRPF6 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RFXANK PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
LBR PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DYNC1H1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
XPO4 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IMMT PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ARCN1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PDCD6IP PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RFC3 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SEC63 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ARL1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
DNAJB6 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
HLTF PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
EFTUD2 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ZW10 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HNRNPM PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DYNLRB1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SMC4 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SF3B6 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
TUBGCP4 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
MAPRE2 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NUP205 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
NUP93 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SMAP1 PHLDA3 25348397 N/A physical interaction ComPPI
MYO1C PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NOC2L PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATXN10 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SLC3A2 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
AHSA1 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CCDC47 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RPN2 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
NDUFA6 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SRPRB PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ATP5MG PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
TMEM33 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RPL38 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
APP PHLDA3 25348397 N/A physical interaction ComPPI
POLR1C PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
IPO4 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CCAR2 PHLDA3 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PHLDA3 SLC25A12 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PHLDA3 GCLM 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PHLDA3 SAMHD1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PHLDA3 FASTKD2 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PHLDA3 MTHFD1L 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PHLDA3 SFXN1 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
PHLDA3 MRPS16 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct

Source Target Pmid Interactiontype Methods Database
URS00009C2950 PHLDA3 27087310 direct interaction,inhibition N/A NPInter

Visualization










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